A5063267106- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Radiopharmaceutical Chemistry and Applications
- Crystallography and molecular interactions
- Click Chemistry and Applications
- Nanoplatforms for cancer theranostics
- Covalent Organic Framework Applications
- Advanced biosensing and bioanalysis techniques
- Radioactive element chemistry and processing
- Medical Imaging Techniques and Applications
- Chemical Synthesis and Analysis
- Air Quality and Health Impacts
- Chemical Synthesis and Characterization
- Nanoparticle-Based Drug Delivery
- Chemical Synthesis and Reactions
- Metal complexes synthesis and properties
- Asymmetric Synthesis and Catalysis
- Monoclonal and Polyclonal Antibodies Research
- RNA Interference and Gene Delivery
- Carbohydrate Chemistry and Synthesis
- Toxic Organic Pollutants Impact
- Lanthanide and Transition Metal Complexes
- Membrane Separation Technologies
- Synthetic Organic Chemistry Methods
- Organometallic Complex Synthesis and Catalysis
Kyungpook National University
2019-2025
Korea Atomic Energy Research Institute
2014-2018
Korea University of Science and Technology
2015-2018
University of Science and Technology
2015-2018
Government of the Republic of Korea
2017-2018
Stanford University
2011-2015
Stanford Medicine
2010-2014
Seoul National University
2004-2014
Korea Institute of Science and Technology
2009
Abstract Radioactive iodine‐labeled, cyclic RGD‐PEGylated gold nanoparticle (AuNP) probes are designed and synthesized for targeting cancer cells imaging tumor sites. These iodine‐125‐labeled cRGD–PEG–AuNP stable in various conditions including a range of pHs high salt temperature conditions. can target selectively be taken up by via integrin α v β 3‐receptor‐mediated endocytosis with no cytotoxicity. The show significant increase the avidity 3 compared to corresponding free cRGD peptides....
A thrombus (blood clot) is formed in injured vessels to maintain the integrity of vasculature. However, obstruction blood by thrombosis slows flow, leading death tissues fed artery and main culprit various life-threatening cardiovascular diseases. Herein, we report a rationally designed nanomedicine that could specifically image obstructed inhibit formation. On basis physicochemical biological characteristics thrombi such as an abundance fibrin elevated level hydrogen peroxide (H2O2),...
Drug Design: An (18)F-labeled caspase-3-sensitive nanoaggregation positron emission tomography tracer was prepared and evaluated for imaging the caspase-3 activity in doxorubicin-treated tumor xenografts. Enhanced retention of (18)F apoptotic tumors is achieved through intramolecular macrocyclization situ aggregation upon activation (see picture).
Chromium is a toxic and carcinogenic heavy metal that originates from various human activities. Therefore, the effective removal of chromium aqueous solutions an extremely important global challenge. Herein, we report chitosan-coated iron oxide nanoparticle immobilized hydrophilic poly(vinylidene) fluoride membrane (Chi@Fe2O3–PVDF) which can potentially be used for efficient hexavalent chromium(VI) by simple filtration process. Membrane easy method treating large volumes water in short...
A new bioremediation method is developed by using a gold nanomaterial-containing radiation-resistant bacterium.
Anionic dyes are one of the most serious contaminants in water as these molecules known to be toxic many living organisms. Herein, we report development functionalized polyvinylidene fluoride membranes modified with chitosan-coated iron oxide nanomaterials (Fe-PVDF) for efficient treatment anionic dye-contaminated water. Aqueous solutions could captured rapidly by passing through membrane under reduced pressure. Under neutral conditions, Fe-PVDF showed a maximum removal capacity 74.6 mg/g...
An efficient method based on a rapid condensation reaction between 2-cyanobenzothiazole (CBT) and cysteine has been developed for (18)F-labeling of N-terminal cysteine-bearing peptides proteins. (18)F-labeled dimeric cRGD ([(18)F]CBTRGD(2)) synthesized with an excellent radiochemical yield (92% radio-HPLC conversion, 80% decay-corrected, isolated yield) purity (>99%) under mild conditions using (18)F-CBT, shown good in vivo tumor targeting efficiency PET imaging. The labeling strategy was...
The epidermal growth factor receptor (EGFR) serves as an attractive target for cancer molecular imaging and therapy. Our previous positron emission tomography (PET) studies showed that the EGFR-targeting affibody molecules (64)Cu-DOTA-ZEGFR:1907 (18)F-FBEM-ZEGFR:1907 can discriminate between high low EGFR-expression tumors have potential patient selection EGFR-targeted Compared with (64)Cu, (18)F may improve of is more suitable clinical application, but labeling reaction requires a long...
Early detection of tumor response to therapy is crucial the timely identification most efficacious treatments. We recently developed a novel apoptosis imaging tracer, <sup>18</sup>F-C-SNAT (C-SNAT caspase-sensitive nanoaggregation tracer), that undergoes an intramolecular cyclization reaction after cleavage by caspase-3/7, biomarker apoptosis. This caspase-3/7–dependent leads enhanced accumulation and retention <sup>18</sup>F activity in apoptotic tumors. study aimed fully examine vivo...
A hybrid membrane consisting of gold nanoparticles immobilized on cellulose acetate has been developed for the selective removal radioactive iodine from various aqueous media.
Wirkstoff-Design: Ein 18F-markiertes Nanoaggregat-bildendes Capase-3-empfindliches Radiopharmakum für die Positronenemissionstomographie wurde hergestellt und Abbildung der Caspase-3-Aktivität in Doxorubizin-behandelten Tumorxenotransplantaten bewertet. Eine verstärkte Retention 18F-Aktivität apoptotischen Tumoren wird durch intramolekulare Makrocyclisierung In-situ-Aggregation nach Caspase-3-Aktivierung erhalten (siehe Bild).
Increasing concerns regarding the adverse effects of radioactive iodine waste have inspired development a highly efficient and sustainable desalination process for treatment iodine-contaminated water. Because high affinity silver towards species, nanoparticles immobilized on cellulose acetate membrane (Ag-CAM) biogenic containing radiation-resistant bacterium Deinococcus radiodurans (Ag-DR) were developed investigated performance in removing iodines from A simple filtration using Ag-CAM...
Efficient and cost-effective removal of radioactive iodine (radioiodine) from contaminated water has become a crucial task, following nuclear power plant disasters. Several materials for removing radioiodine have been reported in the literature. However, most these exhibit some limitations, such as high production cost, slow adsorption kinetics, poor capacity. Herein, we present silver/iron oxide nanocomposites (Ag/Fe3O4) efficient specific anions water. The Ag/Fe3O4 were synthesized using...
Toxic fission products, such as cesium (137Cs) and iodine (129I) are of great concern because their long half-lives high solubility in water. The simultaneous removal Cs I using a single adsorbent is an area increasing interest. In this study, MXene/silver nanowire (AgNW) composite was synthesized through physical mixing employed for iodide (I-) (Cs+) ions from contaminated MXene/AgNW demonstrated excellent adsorption capacities 84.70 26.22 mg/g I- Cs+, respectively. experimental data...
We report here a new small molecule fluorogen and RNA aptamer pair for labeling. The small-molecule is designed on the basis of fluorescently quenched sulforhodamine dye. SELEX (Systematic Evolution Ligands by EXponential enrichment) procedure fluorescence screening in E. coli have been applied to discover that can specifically activate with micromolar binding affinity. systematic mutation truncation study structure determined minimum domain aptamer. A series rationally modified analogues...
Metabolic labeling techniques are powerful tools for cell labeling, tracking and proteomic analysis.However, at present, the effects of metabolic agents on metabolism physiology not known.To address this question, in study, we analyzed cells treated with Ac4ManNAz through microarray analysis analyses membrane channel activity, individual bio-physiological properties, glycolytic flux.According to results, treatment 50 μM led reduction major cellular functions, including energy generation...
There has been worldwide attention on the efficient removal of radioactive iodine, because it is commonly released in nuclear plant accidents. Increasing concerns environmental problems due to iodine are leading us develop stable and sustainable technology for remediation radioelement contaminants. In this work, we report a highly chromatographic method specific rapid capture iodine. The gold nanoparticles immobilized dextran gel columns showed excellent capabilities various conditions....