A5033106740- Antimicrobial Peptides and Activities
- Biochemical and Structural Characterization
- RNA Interference and Gene Delivery
- Antimicrobial agents and applications
- Protein Hydrolysis and Bioactive Peptides
- Plant-Microbe Interactions and Immunity
- Nanoparticle-Based Drug Delivery
- Redox biology and oxidative stress
- Probiotics and Fermented Foods
- Heat shock proteins research
- Insect and Pesticide Research
- Polydiacetylene-based materials and applications
- Water-Energy-Food Nexus Studies
- Parkinson's Disease Mechanisms and Treatments
- Chemical Synthesis and Analysis
- Neurological disorders and treatments
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Nanocomposite Films for Food Packaging
- Dyeing and Modifying Textile Fibers
- Water resources management and optimization
- Protein Structure and Dynamics
- Biopolymer Synthesis and Applications
- Enzyme Structure and Function
- Aquaculture disease management and microbiota
Sunchon National University
2016-2025
Institute for Basic Science
2023
Gwangju Institute of Science and Technology
2023
Gangneung Asan Hospital
2018-2022
University of Ulsan
2017-2022
Ulsan College
2018-2022
Seoul National University
2009-2022
Boramae Medical Center
2019-2022
Seoul Metropolitan Government
2019-2022
Asan Medical Center
2015-2018
A thrombus (blood clot) is formed in injured vessels to maintain the integrity of vasculature. However, obstruction blood by thrombosis slows flow, leading death tissues fed artery and main culprit various life-threatening cardiovascular diseases. Herein, we report a rationally designed nanomedicine that could specifically image obstructed inhibit formation. On basis physicochemical biological characteristics thrombi such as an abundance fibrin elevated level hydrogen peroxide (H2O2),...
A thrombus (blood clot), composed mainly of activated platelets and fibrin, obstructs arteries or veins, leading to various life-threatening diseases. Inspired by the distinctive physicochemical characteristics thrombi such as abundant fibrin an elevated level hydrogen peroxide (H2O2), we developed thrombus-specific theranostic (T-FBM) nanoparticles that could provide H2O2-triggered photoacoustic signal amplification serve antithrombotic nanomedicine. T-FBM were designed target fibrin-rich...
We found that Arabidopsis AtTDX, a heat-stable and plant-specific thioredoxin (Trx)-like protein, exhibits multiple functions, acting as disulfide reductase, foldase chaperone, holdase chaperone. The activity of which contains 3 tetratricopeptide repeat (TPR) domains Trx motif, depends on its oligomeric status. reductase chaperone functions predominate when AtTDX occurs in the low molecular weight (LMW) form, whereas function predominates high (HMW) complexes. Because deletion TPR results...
Biofilms are resistant to antibiotics and a major source of persistent recurring infections by clinically important pathogens. Drugs used for biofilm-associated limited because biofilm-embedded or biofilm-matrix bacteria difficult kill eradiate. Therefore, many researchers developing new effective antibiofilm agents. Among them, antimicrobial peptides have an attractive interest in the development The present study evaluated effects 10 synthetic on growth inhibition, inhibition biofilm...
This study analyzed trends and patterns in the 22 years of research published Health Communication. A content analysis 642 articles examined breadth depth that Communication has achieved since its inception. Readers can thus see history scope health communication as defined pages this journal, juxtapose historical overview backdrop current scholarship appears journal. We also identified some notable for future development journal specifically discipline general.
Recently, the number of patients infected by drug-resistant pathogenic microbes has increased remarkably worldwide, and a studies have reported new antibiotics from natural sources. Among them, chitosan, with high molecular weight α-conformation, exhibits potent antimicrobial activity, but useful applications as an antibiotic are limited its cytotoxicity insolubility at physiological pH. In present study, antibacterial activity low water-soluble (LMWS) α-chitosan (α1k, α5k, α10k masses 1, 5,...
Biofilm-associated infections are difficult to manage or treat as biofilms biofilm-embedded bacteria eradicate. Antimicrobial peptides have gained increasing attention a possible alternative conventional drugs combat drug-resistant microorganisms because they inhibit the growth of planktonic by disrupting cytoplasmic membrane. The current study investigated effects synthetic (PS1-2, PS1-5, and PS1-6) antibiotics on growth, biofilm formation, reduction Pseudomonas aeruginosa Staphylococcus...
Infectious diseases induced by multidrug-resistant bacteria are a challenging problem in medicine because of global rise the drug resistance to pathogenic bacteria. Despite great efforts on development antibiotics and antimicrobial agents, there is still need develop strategy early detect bacterial infections eradicate effectively simultaneously. The innate immune systems various organisms produce peptides, which kill broad range with minimal cytotoxicity mammalian cells. Therefore, peptides...
The rapid induction of drug resistance is considered a fatal drawback conventional antibiotics and requires the continuous development new antibiotics. Accordingly, antibacterial peptides (AMPs) have attracted interest as next-generation many studies been conducted. However, much remains unknown regarding mechanism AMPs effects amino acid sequence changes. We compared structures antifungal HnMc-W (F1W substitution, straight alpha-helical structure), HnMc-WP1 (S9P bending HnMc-WP2 (addition...
Lon, also known as protease La, belongs to a class of ATP-dependent serine protease. It plays an essential role in degradation abnormal proteins and certain short-lived regulatory proteins, is thought possess Ser-Lys catalytic dyad. To examine the structural organization we performed electron microscope analysis. The averaged images Lon with end-on orientation revealed six-membered, ringshaped structure central cavity. side-on view showed two-layered equal distribution mass across equatorial...