Abstract The cystic cavity that develops following injuries to brain or spinal cord is a major obstacle for tissue repair in central nervous system (CNS). Here we report injection of imidazole-poly(organophosphazenes) (I-5), hydrogel with thermosensitive sol–gel transition behavior, almost completely eliminates cavities clinically relevant rat injury model. Cystic are bridged by fibronectin-rich extracellular matrix. fibrotic matrix remodeling mediated metalloproteinase-9 expressed...

A highly flexible and transparent conductive electrode based on consecutively stacked layers of polymer (CP) silver nanowires (AgNWs) fully embedded in a colorless polyimide (cPI) is achieved by utilizing an inverted layer‐by‐layer processing method. This CP‐AgNW composite exhibits high transparency >92% at wavelengths 450–700 nm low resistivity 7.7 Ω ◻ −1 , while its ultrasmooth surface provides large contact area for pathways. Furthermore, it demonstrates unprecedentedly flexibility...

Treatment of osteoarthritis (OA) by administration corticosteroids is a commonly used method in clinics using anti-inflammatory medicine. Oral or intra-articular injection can reduce the pain and progress cartilage degeneration, but they are usually insufficient to show local long-term effects because their fast clearance body. In this study, we suggest an injectable anti-OA drug depot system for sustained release that provides effective therapeutic advantages. Amphiphilic...

Abstract Herein, a novel extracellular matrix (ECM) hydrogel is proposed fabricated solely from decellularized, human fibroblast‐derived (FDM) toward advanced wound healing. This FDM‐gel physically very stable and viscoelastic, while preserving the natural ECM diversity various bioactive factors. Subcutaneously transplanted provided permissive environment for innate immune cells infiltration. Compared to collagen hydrogel, excellent healing indications of treated in full‐thickness wounds are...

Here, we describe a concept for localized and long-term delivery of short interfering RNA (siRNA) using an injectable polyplex hydrogel possessing thermosensitivity biodegradability properties. We prepared low molecular weight polyethyleneimine-poly(organophosphazene) conjugate as thermosensitive cationic polymer that has cleavable ester linkage. The conjugates formed about 100 nm sized polyplexes with siRNAs, the solution turned into at body temperature via hydrophobic interaction. injected...

Abstract Stem‐cell‐based tissue engineering requires increased stem cell retention, viability, and control of differentiation. The use biocompatible scaffolds encapsulating cells typically addresses the first two problems. To achieve fate, fine‐tuned with bioactive molecules are necessary. However, given that fine‐tuning is associated UV irradiation in situ scaffold gelation, this process conflict injectability. Herein, a fine‐tunable injectable 3D hydrogel system developed thermosensitive...

Traumatic damage to the spinal cord does not spontaneously heal, often leading permanent tissue defects. We have shown that injection of imidazole-poly(organophosphazene) hydrogel (I-5) bridges cystic cavities with newly assembled fibronectin-rich extracellular matrix (ECM). The hydrogel-created ECM contains chondroitin sulfate proteoglycans (CSPGs), collagenous fibrils together perivascular fibroblasts, and various fibrotic proteins, all which could hinder axonal growth in matrix. In an...

A transparent electrode comprising Ag nanowires and a polyurethane equipped with Diels–Alder adducts as crosslinkers was successfully fabricated to realize rapidly amendable electrode.

Recently, the number of patients infected by drug-resistant pathogenic microbes has increased remarkably worldwide, and a studies have reported new antibiotics from natural sources. Among them, chitosan, with high molecular weight α-conformation, exhibits potent antimicrobial activity, but useful applications as an antibiotic are limited its cytotoxicity insolubility at physiological pH. In present study, antibacterial activity low water-soluble (LMWS) α-chitosan (α1k, α5k, α10k masses 1, 5,...

Abstract Three‐dimensional (3D) bioprinting, which is being increasingly used in tissue engineering, requires bioinks with tunable mechanical properties, biological activities, and strength for vivo implantation. Herein, a growth‐factor‐holding poly(organophosphazene)‐based thermo‐responsive nanocomposite (TNC) bioink system developed. The properties of the TNC are easily controlled within moderate temperature range (5–37 °C). During printing, bioink, determine 3D printing resolution, can be...

Subchondral stress fracture of the femoral head is a rare condition that usually occurs as an insufficiency in people with poor bone quality. We evaluated clinical characteristics subchondral fatigue fractures occurred young, healthy military recruits.Between January 1998 and November 2001, seven were treated five patients. The this ascertained by assessing course well radiographs, scintigrams, magnetic resonance images.All patients male recruits their early twenties whom pain had developed...

Curcumin, the major phytochemical in turmeric, exerts anti‑proliferative, anticancer and anti‑inflammatory activities various types of cancer cells. Curcumin has been demonstrated to induce apoptosis through multiple signaling pathways; however, its association with survival pathways, including Wnt pathway, is not fully understood. The pathway involved diverse functions, cell development, growth proliferation. This important for metastasis. β‑catenin GSK3β play a key role therefore, members...

The treatment of chronic Achilles tendonitis (AT) often requires prolonged therapy and invasive therapeutic methods such as surgery or endoscopy. To prevent the progression AT, excessive inflammation must be alleviated at an early stage. Corticosteroids nonsteroidal anti-inflammatory drugs are generally prescribed to control inflammation; however, high doses long periods required may lead serious side effects. Herein, a local injectable poly(organophosphazene) (PPZ) – celecoxib (CXB)...

Numerous growth factors are involved in the natural bone healing process, which is precisely controlled a time- and concentration-dependent manner. Mimicking secretion pattern of could be an effective means to maximize regeneration effect. However, achieving sequential delivery various without use multiple materials or complex scaffold designs challenging. Herein, injectable poly(organophosphazene) hydrogel (IPS) encapsulating morphogenetic protein (BMP)-2 TGFβ-1 (IPS_BT) studied mimic...

To generate a good carrier for gene transfection, O-carboxymethyl chitosan-graft-branched polyethylenimine (OCMPEI) copolymers were synthesized by increasing the weight percentage of branched conjugated to carboxyl groups chitosan. These spherical polyplexes with plasmid deoxyribonucleic acid (pDNA) or small interfering ribonucleic (siRNA) had diameters ~200-300 nm ~10-25 nm, respectively, and displayed significant transfection efficiency in normal tumor cells. In particular, expression...

Lung cancer is one of the leading causes death, and mortality rates have steadily been increasing. Recently, several studies were conducted to develop novel, physiologically active compounds from medicinal plant extracts. Several plant-derived extracts molecules regulate inhibit signaling associated with growth proliferation cells. Euryale ferox salisb a that effective against different types cancers. In this study, we investigated apoptotic effects E. extract (ESE) in A549 lung cells,...

Intravenous (IV) route is the most commonly used drug-delivery approach. However, targeting efficiency to tumor through IV delivery usually less than 10%. To address this limitation, we report a new systemic method utilizing injectable and quadruple-functional hydrogels improve passive, active, magnetic targeting, hydrogel-controlled sustained release. The consist of folate/polyethylenimine-conjugated poly(organophosphazene) polymer, which encapsulates small interfering RNA (siRNA) Au-Fe3O4...

This article presents the efficacy of heat-induced MPC-grafting against excessive fibrous capsule formation and related inflammation in tissues surrounding silicone breast implants inserted a pig model.

The purpose of this study was to describe the features angioleiomyomas extremities on ultrasonography (US) and magnetic resonance imaging (MRI).We retrospectively reviewed US MRI findings 29 pathologically confirmed cases in patients. Twenty patients underwent only US; 7 MRI; 2 MRI. Clinical data histopathologic specimens were reviewed.There 19 women 10 men. mean patient age 48.9 years (range, 23-80 years). On US, located primarily subcutaneous fat layer (n = 20 [91%]), oval 17 [77%]), had...