A5017970366- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neonatal and fetal brain pathology
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Tryptophan and brain disorders
- Diet and metabolism studies
- Medical Imaging Techniques and Applications
- Neurogenetic and Muscular Disorders Research
- Advanced MRI Techniques and Applications
- Ion channel regulation and function
- Mesenchymal stem cell research
- Epilepsy research and treatment
- Olfactory and Sensory Function Studies
- Birth, Development, and Health
- Neurogenesis and neuroplasticity mechanisms
- Adipose Tissue and Metabolism
- Stress Responses and Cortisol
- Functional Brain Connectivity Studies
- Spinal Cord Injury Research
- Genetics and Neurodevelopmental Disorders
- Nerve injury and regeneration
- Health, Environment, Cognitive Aging
- Glioma Diagnosis and Treatment
- S100 Proteins and Annexins
Instituto do Cérebro
2015-2024
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2024
Pontifícia Universidade Católica do Rio Grande do Sul
2011-2023
Pontifícia Universidade Católica de São Paulo
2022
Universidade Federal do Rio Grande do Sul
2011-2021
Université de Poitiers
2021
McGill University
2021
Stanford University
2014
Biomedical Research Institute
2005
Fidia Farmaceutici (Italy)
1992
The epidermal growth factor receptor (EGFR) serves as an attractive target for cancer molecular imaging and therapy. Our previous positron emission tomography (PET) studies showed that the EGFR-targeting affibody molecules (64)Cu-DOTA-ZEGFR:1907 (18)F-FBEM-ZEGFR:1907 can discriminate between high low EGFR-expression tumors have potential patient selection EGFR-targeted Compared with (64)Cu, (18)F may improve of is more suitable clinical application, but labeling reaction requires a long...
Epilepsy affects 0.5–1% of the world's population, and approximately a third these patients are refractory to current medication. Given their ability proliferate, differentiate regenerate tissues, stem cells could restore neural circuits lost during course disease reestablish physiological excitability neurons. This study verified therapeutic potential bone marrow mononuclear (BMMCs) on seizure control cognitive impairment caused by experimentally induced epilepsy. Status epilepticus (SE)...
Based on preclinical findings, cellular therapy has become a promising therapeutic approach for neonatal hypoxia-ischemia (HI). However, before translation into the clinical setting, new and effective routes of cell delivery must be determined. Intra-arterial (IA) is an attractive route administration but never been used in HI rats.In this study, we investigated feasibility IA transplantation human umbilical cord blood (HUCB) mononuclear cells treatment long-term behavior dysfunction brain...
Summary Objective Temporal lobe epilepsy ( TLE ) is one of the most common types syndromes in world. Depression an important comorbidity epilepsy, which has been reported patients with and different experimental models epilepsy. However, there no established consensus on brain regions are associated manifestation depression Here, we investigated alterations cerebral glucose metabolism metabolic network pilocarpine‐induced rat model correlated it depressive behavior during chronic phase...
Abstract Generalized pain and fatigue are both hallmarks of fibromyalgia, a syndrome with an indefinite etiology. The treatment options for fibromyalgia currently limited, probably because its intricate pathophysiology. Thus, further basic clinical research on this condition is needed. This study investigated the effects nociceptin/orphanin FQ (N/OFQ) receptor (NOPr) ligands modulation NOP system in preclinical mouse model reserpine-induced fibromyalgia. administration natural agonist N/OFQ...
Neonatal hypoxia ischemia (HI) is the main cause of newborn mortality and morbidity. Preclinical studies have shown that immature rat brain more resilient to HI injury, suggesting innate mechanisms neuroprotection. During neonatal period metabolism experience changes might greatly affect outcome injury. Therefore, aim present study was investigate how in interfere with different stages CNS development. For this purpose, animals were divided into 6 groups: HIP3, HIP7 HIP11 (HI performed at...
Hypoxia and cerebral ischemia (HI) events are capable of triggering important changes in brain metabolism, including glucose metabolism abnormalities, which may be related to the severity insult. Using positron emission microtomography (microPET) with [18F]fluorodeoxyglucose (18F-FDG), this study proposes assess abnormalities adult rats previously submitted neonatal HI model. We hypothesize that metabolic outcomes will associated cognitive deficits magnitude injury. Seven-day-old were...
Major depressive disorder (MDD) leads to pervasive changes in the health of afflicted patients. Despite advances understanding MDD and its treatment, profound innovation is needed develop fast-onset antidepressants with higher effectiveness. When acutely administered, endogenous nucleoside guanosine (GUO) shows antidepressant-like effects several mouse models, including olfactory bulbectomy (OBX) rodent model. OBX advocated possess translational value be suitable assess time course...
Acute treatment with ketamine, an NMDA receptor antagonist, has been reported to be efficacious in treating depression. The goal of our study was evaluate ketamine animal model another important psychiatric disease, post-traumatic stress disorder (PTSD). Fifty-eight male rats were initially divided into four groups: Control+Saline (CTRL+SAL), Control+Ketamine (CTRL+KET), PTSD+Saline (PTSD+SAL) and PTSD+Ketamine (PTSD+KET). To mimic PTSD we employed the inescapable footshock protocol. animals...
Summary Aims In previous studies, transplantation of bone marrow mononuclear cells ( BMMC s) in epileptic animals has been found to be neuroprotective. However, the mechanism by which s act remains unclear. We hypothesize that may provide neuroprotection brain through trophic support. To test our hypothesis, we studied temporal expression neurotrophins after rat hippocampus. Methods Chronically rats were intravenously transplanted with 1 × 10 7 isolated from GFP transgenic mice. Expression...
Sepsis is characterized by a severe and disseminated inflammation. In the central nervous system, sepsis promotes synaptic dysfunction permanent cognitive impairment. Besides sepsis-induced neuronal dysfunction, glial cell response has been gaining considerable attention with microglial activation as key player. By contrast, astrocytes’ role during acute still underexplored. Astrocytes are specialized immunocompetent cells involved in brain surveillance. this context, potential communication...
Food processing greatly contributed to increased food safety, diversity, and accessibility. However, the prevalence of highly palatable processed in our modern diet has exacerbated obesity rates a global health crisis. While accumulating evidence suggests that chronic consumption such foods is detrimental sensory neural physiology, it unclear whether its short-term intake adverse effects. We assessed how (<2 months) three diets varying composition macronutrient content influence olfaction...
Free fatty acid (FFA) receptors FFA1 and FFA4 are omega-3 molecular targets in metabolic diseases; however, their function cancer cachexia remains unraveled. We assessed the role of mouse model induced by Lewis lung carcinoma (LLC) cell implantation. Naturally occurring ligands such as α-linolenic (ALA) docosahexaenoic (DHA), synthetic FFA1/FFA4 agonists GW9508 TUG891, or selective GW1100 AH7614 antagonists were tested. expression other cachexia-related parameters evaluated. TUG891 decreased...
Abstract Prenatal and early postnatal periods are important for brain development neural function. Neonatal insults such as hypoxia‐ischemia (HI) causes prolonged metabolic dysregulation, affecting central nervous system maturation. There is evidence that hypometabolism could increase the risk of adult‐onset neurodegenerative diseases. However, impact non‐pharmacologic strategies to attenuate HI‐induced glucose dysfunction still underexplored. This study investigated long‐term effects...