A5070443457- Neonatal and fetal brain pathology
- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Neonatal Respiratory Health Research
- Anesthesia and Neurotoxicity Research
- Birth, Development, and Health
- Neuroscience of respiration and sleep
- Retinopathy of Prematurity Studies
- Neurological Disease Mechanisms and Treatments
- Diet and metabolism studies
- Amino Acid Enzymes and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Cerebral Palsy and Movement Disorders
- Eicosanoids and Hypertension Pharmacology
- COVID-19 epidemiological studies
- Virology and Viral Diseases
- Neuroscience and Neuropharmacology Research
- Infant Development and Preterm Care
- Adipose Tissue and Metabolism
- Biochemical and Molecular Research
- Mosquito-borne diseases and control
- Neurogenesis and neuroplasticity mechanisms
Universidade Federal do Rio Grande do Sul
2018-2025
Universidade Federal do Rio Grande
2022
3-Hydroxy-3-methylglutaric acidemia (HMGA) is a neurometabolic inherited disorder characterized by the predominant accumulation of 3-hydroxy-3-methylglutaric acid (HMG) in brain and biological fluids patients. Symptoms often appear first year life include mainly neurological manifestations. The neuropathophysiology not fully elucidated, so we investigated effects intracerebroventricular administration HMG on redox bioenergetic homeostasis cerebral cortex striatum neonatal rats....
Abstract Prenatal and early postnatal periods are important for brain development neural function. Neonatal insults such as hypoxia‐ischemia (HI) causes prolonged metabolic dysregulation, affecting central nervous system maturation. There is evidence that hypometabolism could increase the risk of adult‐onset neurodegenerative diseases. However, impact non‐pharmacologic strategies to attenuate HI‐induced glucose dysfunction still underexplored. This study investigated long‐term effects...
The disruption of redox homeostasis and neuroinflammation are key mechanisms in the pathogenesis brain hypoxia-ischemia (HI); medicinal plants have been studied as a therapeutic strategy, generally associated with prevention oxidative stress inflammatory response. This study evaluates neuroprotective role Plinia trunciflora fruit extract (PTE) neonatal rats submitted to experimental HI. HI insult provoked marked increase lipoperoxidation levels glutathione peroxidase (GPx) activity,...
Neonatal hypoxic‐ischemic encephalopathy (HI) is one the main causes of neurological damage in newborns. Pregnancy has emerging as a feasible therapeutic window for preventing central nervous system and been shown to decrease early long‐term HI consequences. However, experimental literature conflicting point that variables, such previous adaptation period exercise (before mating) decisive impact on swimming consequences injured offspring's brain. Briefly, consisted exposing female rats 7...