A5054819592- Telomeres, Telomerase, and Senescence
- Genetics, Aging, and Longevity in Model Organisms
- Ultrasound and Cavitation Phenomena
- Neonatal Respiratory Health Research
- Tryptophan and brain disorders
- Phytochemistry Medicinal Plant Applications
- Ultrasound and Hyperthermia Applications
- Genomics, phytochemicals, and oxidative stress
- Autoimmune and Inflammatory Disorders Research
- Microbial Inactivation Methods
- Adipose Tissue and Metabolism
- Circadian rhythm and melatonin
- Epigenetics and DNA Methylation
- Muscle Physiology and Disorders
- Birth, Development, and Health
- Cystic Fibrosis Research Advances
- Nematode management and characterization studies
- Science and Education Research
- Coffee research and impacts
- Pomegranate: compositions and health benefits
- Chemistry Education and Research
- Sirtuins and Resveratrol in Medicine
- IL-33, ST2, and ILC Pathways
- Dietary Effects on Health
- Plant tissue culture and regeneration
Universidade Federal do Rio Grande do Sul
2015-2024
Pontifícia Universidade Católica do Rio Grande do Sul
2019-2024
University of British Columbia
2017
Hospital de Clínicas de Porto Alegre
2017
Instituto Nacional de Ciência e Tecnologia Translacional em Medicina
2017
Universidade Federal do Rio Grande
2015-2017
Westfälische Hochschule
1956
Growing evidence supports the existence of neurobiological trait abnormalities in individuals at genetic risk for bipolar disorder. The aim this study was to examine potential differences brain-derived neurotrophic factor, cytokines, oxidative stress, and telomere length markers between patients with disorder, their siblings, healthy controls. Thirty-six disorder type I, 39 44 controls were assessed. Serum levels interleukin-6, interleukin-10, tumor necrosis factor-α, C-C motif chemokine 11,...
Bipolar disorder (BD) has been associated with increased rates of age-related diseases, such as type II diabetes, metabolic syndrome, osteoporosis, and cardiovascular disorders. Several biological findings have disorders, including oxidative stress, inflammation, telomere shortening. The objective this study was to compare length among participants BD at early late stages age- gender-matched healthy controls.Twenty-six euthymic subjects 34 controls were recruited. Genomic DNA extracted from...
Introduction Eotaxin-1/CCL11 is a pivotal chemokine crucial for eosinophil homing to the lungs of asthmatic patients. Recent studies also suggest that CCL11 involved in aging process, as it upregulated elderly, and correlated with shorter telomere length leukocytes from children. Despite its potential pro-aging effects, precise contribution underlying mechanisms promotion cellular senescence remains unclear. Therefore, primary goal this study was explore role on development signaling...
Schizophrenia (SZ) is associated with increased somatic morbidity and mortality, in addition to cognitive impairments similar those seen normal aging, which may suggest that pathological accelerated aging occurs SZ. Therefore, we aim evaluate the relationships of age, telomere length (TL), CCL11 (aging inflammatory biomarkers, respectively), gray matter (GM) volume episodic memory performance individuals SZ compared healthy controls (HC). One hundred twelve participants (48 64 HC) underwent...
Adipose-derived stem cells (ADSC) are multipotent implicated in tissue homeostasis. Obesity represents a chronic inflammatory disease associated with metabolic dysfunction and age-related mechanisms, progressive accumulation of senescent compromised ADSC function. In this study, we aimed to explore mechanisms the environment present obesity modulating phenotype. We evaluated phenotypic functional alterations through 18 days treatment. were cultivated conditioned medium supplemented pool...
Background Inhaled nitric oxide (iNO) in high concentration inhibits SARS-CoV-2 replication epithelial cells and may prevent severe disease hospitalized patients. To evaluate safety efficacy of inhaled 160 ppm on supplemental oxygen patients with COVID-19. Methods We conducted an open-label, randomized clinical trial COVID-19 receiving oxygen. Patients were randomly assigned to receive iNO for 6 h addition standard care. The primary endpoint was assessed by incidence adverse events (AEs)....
Objective To evaluate the consequences of plasma from individuals with obesity on parameters associated immunosenescence in unrelated healthy peripheral blood mononuclear cells (PBMC). Methods Freshly isolated PBMC were incubated media supplemented 10% or control subjects for first 4 hours 24 to 120 culture. Results Plasma modulated phenotype PBMC, leading a higher rate apoptosis, lower amounts phospho‐γH2AX and ‐p53, mitochondrial dysfunction. After hours, there was secretion inflammatory...
Obesity is a prevalent multifactorial chronic disorder characterized by metabolic dysregulation. Sustained pro-oxidative mediators trigger harmful consequences that reflect at systemic level and contribute for the establishment of premature senescent phenotype associated with macromolecular damage (DNA, protein, lipids). Telomeres are structures protect chromosome ends six-protein complex called shelterin subject to regulation. Under pro-oxidant conditions, telomere attrition altered...
Microbiota alterations are observed in pathological conditions, and their regulation is a subject of great interest. Gut microbes affected by diet, plant polyphenols may have positive effect on gut microbiota; however, plant‐derived extracts toxic effects. Guarana (Paullinia cupana Mart.) nontraditional medicinal applied worldwide. yields an alkaloid polyphenol‐rich seed with antimicrobial, antioxidant, anti‐inflammatory properties, where caffeine the major compound. We evaluated effects...
Since stressful situations are considered risk factors for the development of depression and there few studies evaluating prevention therapies this disease, in present study we evaluated effect previous physical exercise animals subjected to chronic variable stress (CVS), an animal model depression, on behavior tasks. We also investigated some parameters oxidative Na+, K+-ATPase activity, immunocontent gene expression alpha subunits amygdala hippocampus rats. Young male rats were randomized...
Abstract Evidence on the relationship between genetics and mental health are flourishing. However, few studies evaluating early biomarkers that might link genes, environment, psychopathology. We aimed to study telomere length (TL) epigenetic age acceleration (AA) in a cohort of adolescents with without anxiety disorders (N = 234). evaluated representative subsample participants at baseline after 5 years (n 76) categorized them according their disorder diagnosis both time points: (1) control...
Severe therapy-resistant asthma (STRA) is closely associated with distinct clinical and inflammatory phenoendotypes, which may contribute to the development of age-related comorbidities.Evidence has demonstrated a contribution accelerated telomere shortening on poor prognosis respiratory diseases in adults.Eotaxin-1 (CCL11) an important chemokine for eosinophilic recruitment progression asthma.In last years also been proposed as age-promoting factor.This study aimed investigate association...
Advances in juvenile idiopathic arthritis (JIA) treatment is promoting free disease survival. Cardiovascular (CVD) may emerge as an important cause of morbidity and mortality. Pulse wave velocity (PWV), a surrogate marker arterial stiffness, telomere length (TL) are considered potential predictors CVD its outcomes. The study aim was to assess PWV, TL JIA population test correlation. In cross sectional study, 24 patients, 21 controls for 20 PWV were included. assessed by oscillometric device....
Abstract Background Several risk factors have been involved in the poor clinical progression of coronavirus disease-19 (COVID-19), including ageing, and obesity. SARS-CoV-2 may compromise lung function through cell damage paracrine inflammation; obesity has associated with premature immunosenescence, microbial translocation, dysfunctional innate immune responses leading to response against a range viruses bacterial infections. Here, we comprehensively characterized dysregulation established...
Cystic fibrosis (CF) affects multiple organs, the most severe consequences being observed in lungs. Despite significant progress developing CF transmembrane conductance regulator-specific treatments for lung disease, exploring alternative CF-targeted medications seems reasonable. We sought to evaluate potential beneficial effects of oral benzbromarone as an adjuvant therapy patients with reduced function.
Three Achyrocline satureioides (AS) inflorescences extracts were characterized: (i) a freeze-dried extract prepared from the aqueous extractive solution and (ii) (iii) spray-dried hydroethanol (80% ethanol). The chemical profile, antioxidant potential, antimicrobial activity against intestinal pathogenic bacteria of AS evaluated. In vitro was determined by total reactive potential (TRAP) assay. vivo analysis characterization microbiota performed in male Wistar rats (saline versus treated...