A5022303438- Asthma and respiratory diseases
- Liver Disease Diagnosis and Treatment
- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Liver physiology and pathology
- Vagus Nerve Stimulation Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Olfactory and Sensory Function Studies
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ovarian function and disorders
- Stress Responses and Cortisol
- Cystic Fibrosis Research Advances
- Neuroendocrine regulation and behavior
- Liver Diseases and Immunity
- Respiratory viral infections research
- Drug-Induced Hepatotoxicity and Protection
- Nicotinic Acetylcholine Receptors Study
- Inflammasome and immune disorders
- Mollusks and Parasites Studies
- Xenotransplantation and immune response
- School Health and Nursing Education
- IL-33, ST2, and ILC Pathways
- Seed Germination and Physiology
Pontifícia Universidade Católica do Rio Grande do Sul
2016-2025
Hospital Moinhos de Vento
2025
Universidade dos Açores
2008-2010
Abstract In asthma, there are high levels of inflammatory mediators, reactive oxygen species (ROS), and eosinophil extracellular traps (EETs) formation in airway. Here, we attempted to investigate the ROS involvement EETs release airway inflammation OVA‐challenged mice. Before intranasal challenge with ovalbumin (OVA), animals were treated two inhibitors, N ‐acetylcysteine (NAC) or diphenyleneiodonium (DPI). We showed that NAC treatment reduced cells lung. DPI treatments peroxidase (EPO),...
Abstract Studies have shown autophagy participation in the immunopathology of inflammatory diseases. However, role asthma and eosinophil extracellular traps (EETs) release is poorly understood. Here, we attempted to investigate involvement EETs lung inflammation an experimental model. Mice were sensitized with ovalbumin (OVA), followed by OVA challenge. Before challenge OVA, mice treated inhibitor, 3‐methyladenine (3‐MA). We showed that 3‐MA treatment decreases number eosinophils, peroxidase...
Purpose: Asthma is a highly prevalent chronic inflammatory lung disease characterized by airway hyperresponsiveness to allergens, edema, and increased mucus secretion. Such can be liquefied recombinant human deoxyribonuclease (rhDNase), in which efficacy of rhDNase has been well documented patients with cystic fibrosis, but little studied asthma. In the present study, we investigated whether intranasal administration improved inflammation pulmonary function an experimental model Methods:...
Acute lung injury (ALI) is an inflammatory disease with a high incidence and prevalence that can lead to death. While L-thyroxine widely used as synthetic hormone in the treatment of hypothyroidism, its effects on processes are not fully understood. Physical exercise, recommended for general population, serves ally treating various pathologies. Due this lack understanding how affects immune response, coupled well-known benefits study aimed evaluate L-thyroxine’s lipopolysaccharide-induced...
<title>Abstract</title> • <bold>Background</bold>: Asthma is one of the most prevalent chronic pulmonary diseases, affecting approximately 20 million Brazilian people. Most patients with asthma in Brazil present uncontrolled disease, leading to high morbidity and mortality rates. Therefore, an effective educational intervention focused on management Primary Health Care (PHC) expected reduce hospitalization rates, emergency visits, direct public health costs, improving quality life patients....
The correlation between apoptosis and early bovine embryonic loss is still not fully elucidated. In the present study, relationship arrest of embryos at different stages development was evaluated. We used 7 days after in vitro maturation fertilization, morphologic biochemical apoptotic analyses were performed by using a phase contrast microscope terminal transferase dUTP nick end-labelling respectively. For statistic, cell ratio (ACR) determined as percentage cells per embryo. To evaluate...
Abstract Asthma is characterized by the influx of inflammatory cells, especially eosinophils as well reactive oxygen species (ROS) production, driven release T helper 2 (Th2)‐cell‐associated cytokines. The cholinergic anti‐inflammatory pathway (CAP) inhibit cytokines production and controls inflammation. Thus, we investigated effects pharmacological activation CAP neostigmine on oxidative stress airway inflammation in an allergic asthma model. After OVA challenge, mice were treated with...
Respiratory viral infections are the leading cause of asthma exacerbations. Eosinophil activation results in formation eosinophil extracellular traps (EETs), which release web-like structures DNA and proteins that bind, disarm extracellularly kill pathogens.We investigated whether respiratory syncytial virus (RSV) vitro could induce EETs bronchoalveolar lavage fluid eosinophils a murine model asthma.BALB/cJ mice (6-8 weeks old) were sensitized with 2 subcutaneous injections ovalbumin (20 μg)...
Acute lung injury (ALI) is an inflammatory process, and has high incidence mortality. ALI the acute respiratory distress syndrome are two common complications worldwide that result in failure, sepsis, death. Pro-inflammatory substances, such as cytokines chemokines, responsible for activating body's defense mechanisms usually mediate processes. Therefore, research of substances decrease uncontrolled response organism seen potential patients with ALI. Octyl gallate (OG) a phenolic compound...
Contents The overall aim of the present study was to evaluate in vitro development ability oocytes recovered from 56 Holstein Frisian heifers with low [group 1 (G1): <13 mg /dl], moderate 2 (G2): 13–16 /dl] and high 3 (G3): >16 plasma urea nitrogen (PUN) concentrations, determine whether PUN concentrations affect competence progress blastocysts after fertilization. In oocyte embryo assessed by blastocyst rates, total cell numbers apoptosis. Blood samples for determination were...
Little is known about a synergistic effect of periodontitis and obesity on systemic biomarkers possible periodontal treatment may exert. This study aimed to evaluate the impact inflammation metabolic profile in obese non-obese rats.Sixty male Wistar rats were randomly divided six groups differentiated by diet status: no (G1 G4), untreated ligature-induced (G2 G5), treated (G3 G6). Groups G4, G5, G6 exposed cafeteria induce obesity. Periodontitis was induced silk ligatures over 4 weeks (G2,...
Contents The objectives of this work are to determine if exogenous supplementation with α‐tocopherol increases the in vitro fertilization (IVF) rate bovine oocytes and improves viability selected spermatozoa after ‘swim‐up’. percentage fertilized was significantly but negatively correlated ( r = −0.941, p < 0.01) concentration α‐tocopherol. control resulted 95% oocytes, which decreased as follows: 25 μM (α25) 86%, 50 (α50) 74%, 100 (α100) 66% 200 (α200) 56%. Relatively sperm ‘swim‐up’...
Respiratory syncytial virus (RSV) is the major cause of lower respiratory tract infections in children under 1 year. RSV vaccines are currently unavailable, and suffering from multiple reinfections by same viral strain fail to develop protective responses. Although RSV-specific antibodies can be detected upon infection, these have limited neutralizing capacity. Follicular helper T (Tfh) cells specialized providing signals B help production affinity maturation antibodies, mainly via...
Tyrophagus putrescentiae (Tp) is a source of aeroallergen that causes allergic diseases.To describe an acute and chronic murine model asthma with Tp extract no systemic sensitization use adjuvant.Mites from dust sample were cultured raw was produced. Female BALB/c mice (6-8 weeks) challenged intranasally or Dulbecco's phosphate-buffered saline, for 10 consecutive days (acute protocol) 6 weeks (chronic protocol). Twenty-four hours after the last intranasal challenge, bronchoalveolar lavage...
Octyl gallate (OG) is an antioxidant commonly used in food, although there no definition of its acceptable daily intake. There are reports vitro and vivo showing that food additives drugs can alter lipid metabolism. Lipid droplet accumulation hepatic cells one the main findings unregulated metabolism strongly related to development nonalcoholic fatty liver disease (NAFLD). In this study, we investigated effects OG on hepatocellular carcinoma cell line (HepG2). The results have shown, for...