A5041957638- Cholinesterase and Neurodegenerative Diseases
- Alkaloids: synthesis and pharmacology
- Chemical synthesis and alkaloids
- Computational Drug Discovery Methods
- Phytochemistry Medicinal Plant Applications
- Ethnobotanical and Medicinal Plants Studies
- Nicotinic Acetylcholine Receptors Study
- Phytochemistry and Bioactivity Studies
- Herbal Medicine Research Studies
- Pesticide Exposure and Toxicity
- Traditional and Medicinal Uses of Annonaceae
- Medicinal Plants and Neuroprotection
- Neuroinflammation and Neurodegeneration Mechanisms
- Phenothiazines and Benzothiazines Synthesis and Activities
- Medicinal Plant Extracts Effects
- Antioxidant Activity and Oxidative Stress
- Plant Toxicity and Pharmacological Properties
- Natural product bioactivities and synthesis
- X-ray Diffraction in Crystallography
- Bee Products Chemical Analysis
- Crystallization and Solubility Studies
- Insect Pest Control Strategies
- Neonatal and fetal brain pathology
- Complementary and Alternative Medicine Studies
- Education and Digital Technologies
Universidade Federal do Rio Grande do Sul
2013-2025
Universidade Federal do Rio Grande
2023
The study was aimed at evaluating medicinal and therapeutic potentials of two Lycopodiaceae species, Lycopodium clavatum (L.) thyoides (Humb. & Bonpl. ex Willd), both used in South American folk medicine for central nervous system conditions. Alkaloid extracts were evaluated chemical characterization, acetylcholinesterase antioxidant activities. alkaloid obtained by alkaline extraction determined each species GC/MS examination. evaluation the anticholinesterase activities tested determining...
Indole alkaloids and synthetic indole derivatives are well known for their therapeutic importance. In fact, preclinical clinical studies had already demonstrated several pharmacological activities these compounds. Here, we overview the multifunctional potential of molecules inhibition enzymes related to neurodegenerative disease: acetylcholinesterase (AChE), butyrylcholinesterase (BChE), monoamine oxidases A B (MAO-A MAO-B). focus will be given on Psychotria L. genus, considering its...
Flavonoids are polyphenols that ubiquitous in plants and frequently consumed the diet. They suggested to have many beneficial actions on human health, including anti-inflammatory activity. Their properties been studied a number of cell types, but little is known about their effects neutrophil biology. Consequently, we selected 25 flavonoids with different structural features evaluate vitro inhibition rat polymorphonuclear (PMN) chemotaxis, employing modified Boyden chamber. Migratory...
Huperzine A, a Lycopodium alkaloid produced by Chinese folk herb Huperzia serrata (Lycopodiaceae), has been shown to be promising agent for the treatment of Alzheimer's disease due its potent acetylcholinesterase (AChE) activity, as well efficacy in memory aged patients. Thus, effects two species habitats Brazil (H. quadrifariata and H. reflexa) with described vitro AChE inhibition activities were studied their on mice brain determined after single intraperitoneal (i.p.) injection. The...
Neonatal hypoxia ischemia (HI) plays a role in the etiology of several neurological pathologies and causes severe sequelae. Acetylcholine is neurotransmitter central nervous system cholinesterase inhibitors have demonstrated positive action over HI induced deficits. In order to evaluate effects pre post-hypoxia administrations galantamine, inhibitor, model perinatal HI, Wistar rats post-natal day 7 (PND7) were subjected combination unilateral occlusion right carotid artery with exposure 1h...
The alkaloid extracts of four Huperzia and one Lycopodiella species, from Brazilian habitats, were tested for their in vitro anticholinesterase activities. IC(50) values showed a potent acetylcholinesterase inhibition H. reflexa (0.11 ± 0.05 μg/mL), followed by quadrifariata (2.0 0.3 acerosa (5.5 0.9 heterocarpon (25.6 2.7 μg/mL) L. cernua (42.6 1.5 μg/mL). A lower butyrylcholinesterase was observed all species with the exception (8.3 whose extract presented selectivity pseudocholinesterase....
Cholinesterase enzymes are important targets for the therapy of Alzheimer's disease.Tacrine-based dual binding site cholinesterases inhibitors potential disease-modifying anti-Alzheimer drug candidates.In present work, we described synthesis a series chiral homo-and heterodimers bis( 7)-tacrine connected by heptylene chain as spacer with methyl substituent at C-3 position alicyclic region tacrine nucleus and/or chlorine atom attached to C-6.Friedländer cyclocondensation between (R) or (S)...
Spinal cord injury (SCI) is a medical condition that currently lacks effective treatment. Galantamine reversible, competitive acetylcholinesterase inhibitor, used to treat patients with Alzheimeŕs disease. It has been demonstrated galantamine increases cerebral neurogenesis and neuroprotective effect by binding nicotinic receptors an anti-inflammatory due its allosteric the α7nAChR. In present study, effects of on functional recovery histological outcome in rat contusion model SCI were...
Heliopsis longipes is a common spice and medicinal plant widely used in Mexico South America due to its mouth anesthetic, analgesic, anti-inflammatory properties related spilanthol content. Previous reports have demonstrated that N-alkylamides exhibit cytotoxic effect against different cancer cell lines; however, the anti-cancer potential of species remains unknown. Therefore, we investigated effects H. extract (HLE) on HeLa, K-562, MCF-7, HaCaT cells. HLE displayed significative...
Passiflora incarnata L. (Passifloraceae) has been traditionally used for treatment of anxiety, insomnia, drug addiction, mild infections, and pain. The aim this study was to investigate the effect a commercial extract P. in analgesia induced by alcohol withdrawal syndrome rats. In addition, brain-derived neurotrophic factor interleukin-10 levels were evaluated prefrontal cortex, brainstem, hippocampus. Male adult rats received oral gavage: (1: water group) 19 days, 1 day interval (8 days);...