A5088122095- Phytochemistry Medicinal Plant Applications
- Alkaloids: synthesis and pharmacology
- Chemical synthesis and alkaloids
- Traditional and Medicinal Uses of Annonaceae
- Natural product bioactivities and synthesis
- Phytochemicals and Antioxidant Activities
- Essential Oils and Antimicrobial Activity
- Phytochemistry and Biological Activities
- Marine Sponges and Natural Products
- Natural Compound Pharmacology Studies
- Insect Pest Control Strategies
- Agricultural and Food Sciences
- Medicinal Plants and Neuroprotection
- Analytical Chemistry and Chromatography
- Plant tissue culture and regeneration
- Psidium guajava Extracts and Applications
- Sesquiterpenes and Asteraceae Studies
- Bioactive Compounds and Antitumor Agents
- Plant Toxicity and Pharmacological Properties
- Cholinesterase and Neurodegenerative Diseases
- Phytochemical compounds biological activities
- Banana Cultivation and Research
- Enzyme Catalysis and Immobilization
- Bee Products Chemical Analysis
- Plant biochemistry and biosynthesis
Universidade Federal do Rio Grande do Sul
2015-2024
University of Rio Grande and Rio Grande Community College
2021-2022
Universidade de Caxias do Sul
2021
Universidade Federal do Rio Grande
2016-2019
Instituto de Ciências Farmacêuticas
2014-2018
Brazilian Agricultural Research Corporation
2011
National Institute of Health Dr. Ricardo Jorge
2006
Universidade Federal do Paraná
2005
Universidade Federal de Pernambuco
1986
ABSTRACT In this study, we show the leishmanicidal effects of a chloroform fraction (CLF) and purified indole alkaloid obtained from crude stem extract Peschiera australis against Leishmania amazonensis , causative agent cutaneous leishmaniasis in New World. bioassay-guided chemical fractionation, activity CLF completely irreversibly inhibited promastigote growth. This was also active amastigotes infected murine macrophages. Chemical analysis identified an iboga-type coronaridine as one its...
The standardized extract of Ginkgo biloba (EGb 761) has been widely employed for its significant benefit in neurodegenerative disorders. Although antioxidative actions have attributed to this extract, the mechanisms multiple principles involved pharmacological activity are not completely established. Parkinson's and Alzheimer's diseases frequently associated with oxidative stress defects cellular protective mechanisms. In study, lipid peroxidation (LPO) antioxidant enzymes, catalase (CAT)...
Equisetum giganteum L., commonly called "giant horsetail", is an endemic species of Latin America. Its aerial parts have been widely used in ethnomedicine as a diuretic and herbal medicine food supplements raw material. The phenolic composition E. stems was studied by liquid chromatography coupled to diode array detection (LC–DAD) electrospray ionization-tandem mass spectrometry (LC–ESI-MS/MS), which identified caffeic acid derivatives, flavonoids styrylpyrones. most abundant glycosilated...
The study was aimed at evaluating medicinal and therapeutic potentials of two Lycopodiaceae species, Lycopodium clavatum (L.) thyoides (Humb. & Bonpl. ex Willd), both used in South American folk medicine for central nervous system conditions. Alkaloid extracts were evaluated chemical characterization, acetylcholinesterase antioxidant activities. alkaloid obtained by alkaline extraction determined each species GC/MS examination. evaluation the anticholinesterase activities tested determining...
Alkaloid fractions of Psychotria suterella (SAE) and laciniata (LAE) as well two monoterpene indole alkaloids (MIAs) isolated from these were evaluated against monoamine oxidases (MAO-A -B) obtained rat brain mitochondria. SAE LAE analysed by HPLC-PDA UHPLC/HR-TOF-MS leading to the identification compounds 1, 2, 3 4, whose identity was confirmed NMR analyses. Furthermore, submitted enzymatic assays, showing a strong activity MAO-A, characterized IC50 values 1.37 ± 1.05 2.02 1.08 μg/mL,...
Indole alkaloids and synthetic indole derivatives are well known for their therapeutic importance. In fact, preclinical clinical studies had already demonstrated several pharmacological activities these compounds. Here, we overview the multifunctional potential of molecules inhibition enzymes related to neurodegenerative disease: acetylcholinesterase (AChE), butyrylcholinesterase (BChE), monoamine oxidases A B (MAO-A MAO-B). focus will be given on Psychotria L. genus, considering its...
Interesting analgesic activity has been previously identified in alkaloids isolated from the genus Psychotria (Rubiaceae). We here report of umbellatine, a new glycoside indole monoterpene alkaloid umbellata. Umbellatine produced dose-dependent (100-300 mg/kg) effect, partially reversed by naloxone, tail-flick and hot-plate models. These results suggest an effect at least part associated with activation opioid receptors. In formalin- capsaicininduced pain models, umbellatine elicited...
Two new benzophenones were isolated from the leaves of Hypericum carinatum. Their structures established on basis 2D NMR spectroscopic analyses and mass spectrometry as cariphenone A (6-benzoyl-5,7-dihydroxy-2,2,8-trimethyl-2H-chromene) (1) B (8-benzoyl-5,7-dihydroxy-2,2,6-trimethyl-2H-chromene) (2). Five known compounds, phloroglucinol derivative uliginosin (3), 1-eicosanol, sitosterol, stigmasterol, campesterol, also characterized. Compounds 1−3 evaluated for their total antioxidant...