A5042042019- Phytochemistry Medicinal Plant Applications
- Drug Solubulity and Delivery Systems
- Phytochemicals and Antioxidant Activities
- Phytoestrogen effects and research
- Plant tissue culture and regeneration
- Natural product bioactivities and synthesis
- Heavy Metals in Plants
- Growth and nutrition in plants
- Essential Oils and Antimicrobial Activity
- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- Bee Products Chemical Analysis
- Natural Antidiabetic Agents Studies
- Enzyme Catalysis and Immobilization
- Pharmaceutical studies and practices
- Coenzyme Q10 studies and effects
- Agricultural and Food Sciences
- Algal biology and biofuel production
- Analytical Methods in Pharmaceuticals
- Antioxidant Activity and Oxidative Stress
- Natural Compounds in Disease Treatment
- Chromatography in Natural Products
- Cardiac Ischemia and Reperfusion
- Phytochemistry and Bioactivity Studies
- Cardiovascular Function and Risk Factors
Universidade Federal do Rio Grande do Sul
2016-2025
Universidade Federal do Rio Grande
2007-2023
Instituto de Ciências Farmacêuticas
2003-2020
Universidade Federal do Rio de Janeiro
2014
Universidade Federal de Minas Gerais
2010
Université de Montpellier
1990-1991
Equisetum giganteum L., commonly called "giant horsetail", is an endemic species of Latin America. Its aerial parts have been widely used in ethnomedicine as a diuretic and herbal medicine food supplements raw material. The phenolic composition E. stems was studied by liquid chromatography coupled to diode array detection (LC–DAD) electrospray ionization-tandem mass spectrometry (LC–ESI-MS/MS), which identified caffeic acid derivatives, flavonoids styrylpyrones. most abundant glycosilated...
Achyrocline satureioides, popularly known as "marcela", is a medicinal plant found in South America. This rich flavonoids, which have been reported to exert numerous biological activities. The aim of this study was purify, identify and evaluate the mechanisms underlining anticancer activity A. satureioides flavonoids glioma cell lines (U87, U251 C6) well their comparative toxicity normal brain cells (primary astrocytes, neurons organotypic hippocampal cultures). main present are luteolin,...
The objective of this study was to explore the therapeutic effect blueberries on hematological parameters, oxidative stress, and interleukin-10 levels in acute hemolytic anemia induced by administration an intraperitoneal injection 40 mg/kg phenylhydrazine. Male Wistar rats were divided into three groups: Control, (PHZ), plus (PHZ+BB). Blueberries administered via oral gavage (250 mg/day). erythrocyte osmotic fragility, splenomegaly, iron metabolism, analysis, reactive oxygens species,...
Background/Objectives: Our group has been trying to bring scientific rationale the quality, safety and efficacy of Brazilian medicinal plants. This work was first step a broader project evaluating potential Monteverdia ilicifolia capsules for managing dyspepsia in randomized, double-blind clinical trial. M. is native species widely used traditional medicine treating gastric disturbances. The central aim present develop containing an standardized spray-dried extract (SDP) on lab scale...
Objective: To investigate whether the regular administration of blueberry extract and low-intensity resistance exercise training (RT), either alone or in combination, during development monocrotaline (MCT)-induced severe pulmonary arterial hypertension (PAH) rats protect left ventricle (LV) from redox dysregulation pathological remodeling. Methods: Groups seven male Wistar were formed for experiment: sedentary control; hypertensive; hypertensive blueberry; blueberry. PAH was experimentally...
Ilex paraguariensis St. Hilaire is a South American tree from which leaves and twigs are used to prepare commonly consumed tea in several countries. The plant known as "erva-mate" Portuguese or "yerba mate" Spanish. Considering the potential use of saponins surfactant well its therapeutic potential, present work was designed propose extraction quantitation methods for paraguariensis. were extracted by decoction, hydrolyzed quantified HPLC method with UV detection. concentration expressed...
Non-alcoholic steatohepatitis (NASH) is a frequent condition in obese patients that may progress to end-stage liver disease. This study was designed evaluate the modulation of this by use quercetin (Q), flavonoid largely found vegetable foods, with known anti-inflammatory and antioxidant properties, experimental model non-alcoholic using diet deficient methionine choline (MCD). Male C57BL6 mice were divided into four groups (n = 16): (i) Control plus vehicle (control ration...
Abstract Background and Purpose In cor pulmonale , the increased afterload imposed on right ventricle (RV) generates a maladaptive response, impairing contractile cardiac function. Oxidative mechanisms play an important role in pathophysiology progression of this disease. The administration pterostilbene (PTS), phytophenol with antioxidant potential, may represent therapeutic option. present study, we evaluated effect PTS complexed hydroxypropyl‐β‐cyclodextrin (HPβCD) hypertrophy, function...
Objective: To evaluate the effect of different cyclodextrins (β-cyclodextrin [β-CD], methyl-β-cyclodextrin [Mβ-CD], or hydroxypropyl-β-cyclodextrin [HPβ-CD]) and/or hydrophilic polymers (carboxymethylcellulose, hydroxypropylmethylcellulose [HPMC], polyethyleneglycol, polyvinylpyrrolidone [PVP]) on daidzein solubility in water.
Cancer is the major public health problem worldwide; consequently, search for new chemotherapeutic drugs constant. Most of these agents are derived from natural sources, which consistent basis modern anticancer medicines. In this context, numerous studies indicate flavonoids as a potential class secondary metabolites therapy. review, special attention was addressed to present in Achyrocline satureioides, widely used medicinal plant with several and well established range biological...
Advanced glycation end‐products (AGEs) are considered potent molecules capable of promoting neuronal cell death and participating in the development neurodegenerative disorders such as Alzheimer's disease (AD). Previous studies have shown that AGEs exacerbate β‐amyloid (Aβ) aggregation AGE‐related cross‐links also detected senile plaques. Acrolein (ACR) is an α, β‐unsaturated aldehyde found environment thermally processed foods, which can additionally be generated through endogenous...
Rosmarinic acid (RA) is a phenolic compound that presents well-documented anti-inflammatory, antioxidant and antitumor activities, based on its pharmacological potential poor bioavailability, several solid dosage forms have been developed to RA delivery. Therefore, in literature, there are no reports about compatibility with excipients. In this regard, the aim of present study was evaluate, for first time, excipients commonly used at 1:1 (RA:excipient) ratio using differential scanning...