A5101489837- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Phytochemistry Medicinal Plant Applications
- CRISPR and Genetic Engineering
- RNA Interference and Gene Delivery
- Lysosomal Storage Disorders Research
- Natural Antidiabetic Agents Studies
- Ethnobotanical and Medicinal Plants Studies
- Organ Transplantation Techniques and Outcomes
- Biotechnology and Related Fields
- Nosocomial Infections in ICU
- Genomics and Rare Diseases
- Phytochemicals and Antioxidant Activities
- Nitric Oxide and Endothelin Effects
- Drug-Induced Hepatotoxicity and Protection
- Heat shock proteins research
- Biochemical effects in animals
- Endoplasmic Reticulum Stress and Disease
- Eicosanoids and Hypertension Pharmacology
- Carcinogens and Genotoxicity Assessment
- Diet, Metabolism, and Disease
- Genomics, phytochemicals, and oxidative stress
- DNA and Nucleic Acid Chemistry
- Abdominal vascular conditions and treatments
- Ginkgo biloba and Cashew Applications
Santa Casa Hospital
2024
Universidade Federal do Rio Grande do Sul
2010-2022
Hospital de Clínicas de Porto Alegre
2011-2022
National Institute on Population Medical Genetics
2019
Universidade Luterana do Brasil
2010-2015
Pontifícia Universidade Católica do Rio Grande do Sul
2006
In hepatic toxicity induced in rats by two injections of thioacetamide (TAA, 350 mg/kg with an interval 8 hr), the action quercetin was investigated. After 96 hr, TAA administration resulted necrosis, significant increases serum transaminase activity, and lipoperoxidation. Thioacetamide-induced hepatotoxicity also showed changes antioxidant enzymes liver rats, alterations p-ERK 1/2 (phosphorylated extracellular-signal related kinase 1/2) as well imbalance between proapototic protein Bax...
Objective: To evaluate the effectiveness of Brasília Teddy Bear Hospital Project (TBH) as a health education strategy for children. Theoretical Framework: Children may have negative perception hospital environments, generating fear and anxiety, condition known iatrophobia. Method: A quasi-experimental pre-test/post-test study that included school-age children treated in public schools two hospitals. Data collection was based on forms used dynamics with children, which contained information...
Non-alcoholic steatohepatitis (NASH) is a frequent condition in obese patients that may progress to end-stage liver disease. This study was designed evaluate the modulation of this by use quercetin (Q), flavonoid largely found vegetable foods, with known anti-inflammatory and antioxidant properties, experimental model non-alcoholic using diet deficient methionine choline (MCD). Male C57BL6 mice were divided into four groups (n = 16): (i) Control plus vehicle (control ration...
Objective . In this study, we evaluated the efficacy of simvastatin in treatment nonalcoholic steatohepatitis induced by methionine and choline-deficient diet mice its possible effect on factors involved pathogenesis disease including oxidative stress endoplasmic reticulum stress. Method Male C57BL6 were fed either a normal (control) or for four weeks then treated orally with (4 mg/kg once day) two final weeks. At end experimental period, liver integrity, biochemical analysis, hepatic...
CONTEXT: Croton cajucara Benth is a plant found in Amazonia, Brazil and the bark leaf infusions of this have been popularly used to treat diabetes hepatic disorders. OBJECTIVES: This study investigated effects hepatics alterations genotoxic antidiabetic effect extracts treatment streptozotocin-induced diabetic rats. METHODS: Male Wistar rats were divided into six groups: control rats; treated with extract during 5 20 days; rats, days. Diabetes was induced by single intraperitoneal injection...
Hepatocellular carcinoma (HCC) is the third most frequent cause of cancer deaths throughout world. This study was aimed to analyze oxidative stress and cell damage in a multistage model liver carcinogenesis induced by diethylnitrosamine (DEN) rats. Male Wistar rats weighing 145-150 g were divided into three groups: control, precancerous lesions (PL) (which received 100 mg DEN once week every 6 weeks up 28 weeks), advanced HCC (50 once/twice per 19 weeks). Lipid peroxidation (TBARS),...
Mucopolysaccharidosis type I (MPS I) is an inherited disease caused by deficiency of the enzyme alpha-l-iduronidase (IDUA). MPS affects several tissues, including brain, leading to cognitive impairment in severe form disease. Currently available treatments do not reach brain. Therefore, this study, we performed nasal administration (NA) liposomal complexes carrying two plasmids encoding for CRISPR/Cas9 system and IDUA gene targeting ROSA26 locus, aiming at brain delivery mice.Liposomes were...
Liver diseases are a major public health problem, accounting for significant number of hospital visits and admissions an increasing mortality rate. Melatonin (MLT) is powerful antioxidant molecule that has been shown to be beneficial under various conditions. The objective was evaluate the effect MLT on experimental liver cirrhosis induced by carbon tetrachloride (CCl4) in rats.Twenty male Wistar rats (230-250 g) were divided into four groups. I: control group (CO); II: CO + MLT; III: CCl4;...
Croton cajucara Benth is a plant found in Amazonia, Brazil and the bark leaf infusion of this have been popularly used to treat diabetes hepatic disorders. The present study was designed evaluate oxidative stress as well therapeutic effect (1.5 mL C. extract i.g.) rats with streptozotocin-induced diabetes. tested an aqueous for its phytochemical composition, antioxidant activity vitro also evaluated. Lipid peroxidation superoxide dismutase, catalase, glutathione reductase activities were...
Melatonin (MLT) is a potent antioxidant molecule that shown to have beneficial effect in various pathological situations, due its action against free radicals.
Rare genetic disorders are currently in the spotlight due to elevated number of different conditions and significant total affected patients. The study these is extremely helpful for elucidation physiological processes related with complex disorders. Isolated populations instrumental disorders, considering their homogeneity high proportion patients a small geographic area. These favorable lead creation new discipline, known as "population medical genetics", which integrates genetics,...
PURPOSE: To evaluate the effects of topical liver hypothermia and IPC combination against I/R injury after initial reperfusion. METHODS: In 32 Wistar rats, partial ischemia was induced for 90 minutes in normothermia (IN), ischemic preconditioning (IPC), 26ºC (H) plus (H+IPC). MAP, body temperature bile flow were recorded each 15 minutes. Plasmatic markers tissue antioxidant defenses assessed 120 RESULTS: MAP remained constant during all experiment. Bile returned to levels similar controls 45...
Introduction: The gastrointestinal system is frequently affected in patients with diabetes mellitus (DM). Some of these alterations are due to oxidative stress and the production free radicals. present study was designed evaluate whether treatment superoxide dismutase (SOD) exerts protection on established bowel experimental induced by streptozotocin. We measured lipid peroxidation, activity DNA damage. Materials Methods: used anorectal pressure nitrosative an inflammatory score measure...
Introdução: A epidemia do tabagismo continua sendo um dos maiores desafios de saúde pública, e o surgimento cigarros eletrônicos (e-cigarrettes) trouxe uma nova dimensão ao problema, com destaque para a dependência à nicotina doenças respiratórias graves, como EVALI. Metodologia: Trata-se revisão integrativa da literatura focada nos fatores relacionados uso em quais dimensões ela afeta qualidade vida usuário. Resultados: Os resultados indicam que os e-cigarrettes, apesar promovidos menos...
O presente relato de experiência baseia-se no projeto extensão "Saúde e Bem-Estar para Idosos", realizado por acadêmicos do 4º período Medicina Instituto Tocantinense Presidente Antônio Carlos (ITPAC) que visa promover a saúde qualidade vida dos idosos residentes Abrigo João XXIII, em Porto Nacional-TO. Este trabalho destaca importância da integração entre teoria prática na formação acadêmica, permitindo os estudantes apliquem seus conhecimentos contextos reais contribuam o bem-estar...