A5009260986- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Cardiac Ischemia and Reperfusion
- Thermal Regulation in Medicine
- Cardiac Arrest and Resuscitation
- Anesthesia and Neurotoxicity Research
- Hemoglobin structure and function
- Organ Donation and Transplantation
- Liver Disease Diagnosis and Treatment
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Mechanical Circulatory Support Devices
- Eicosanoids and Hypertension Pharmacology
- Nitric Oxide and Endothelin Effects
- Pancreatic and Hepatic Oncology Research
- Appendicitis Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Occupational Health and Performance
- Congenital Diaphragmatic Hernia Studies
- Blood transfusion and management
- Sepsis Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatitis Pathology and Treatment
- Injury Epidemiology and Prevention
- Thermoregulation and physiological responses
Hospital de Clínicas de Porto Alegre
2015-2022
Universidade Federal do Rio Grande do Sul
2006-2020
Universidade Luterana do Brasil
2017-2018
Scientific Methods (United States)
2018
Hospital Mãe de Deus
2002-2018
Hospital de Clínicas
2018
Marymount University
2007
Irmandade da Santa Casa de Misericórdia de São Paulo
2004
University of Turin
1999
Ludwig-Maximilians-Universität München
1996-1998
In subjects who have undergone acute preoperative normovolemic hemodilution (ANH), intraoperative hemorrhage is generally treated by immediate return of autologous blood collected during ANH. Simply increasing oxygen content hyperoxic ventilation (HV, inspiratory fraction [FIO2] 1.0) might compensate for the anemia, allow further ANH, and delay onset return.This study 1) evaluated effects HV (FIO2 upon ANH to a hemoglobin (Hb) concentration 7 g per dL in anesthetized dogs ventilated with...
BACKGROUND: Intravenously administered perfluorocarbon (PFC) emulsions increase oxygen solubility in plasma. PFC might therefore temporarily replace red cells (RBCs) lost during intraoperative hemorrhage. In patients who have undergone hemodilution, the return of autologous blood may be delayed by administration PFC, and RBCs saved for transfusion after surgical bleeding is stopped cleared reticuloendothelial system. STUDY DESIGN AND METHODS: 22 anesthetized, hemodiluted dogs (hemoglobin...
The influence of severe acute normovolemic hemodilution (ANH) on myocardial contractility (MC) was investigated in 14 splenectomized, anesthetized dogs. MC assessed by the maximum rate left ventricular pressure increase (LVdp/dt(max)), end-systolic elastance (Ees), and preload recruitable stroke work (PRSW) (conductance catheter, pressure-volume relationship). Measurements perfusion oxygenation (radioactive microsphere technique) assured comparability model to previously performed studies....
Hemorrhagic shock and resuscitation triggers a global ischemia/reperfusion phenomenon, in which activated leukocytes are considered strong contributors to the ensuing tissue damage.The aim of study was investigate effects hypertonic saline dextran (HSD) on early leukocyte/endothelial interactions (intravital fluorescence microscopy) rat model hemorrhagic (1 hour at mean arterial pressure 40 mm Hg). The performed with lactated Ringer's solution (RL, four times shed blood/20 minutes, n = 6),...
The influence of severe acute normovolemic hemodilution (ANH) on myocardial contractility (MC) was investigated in 14 splenectomized, anesthetized dogs.MC assessed by the maximum rate left ventricular pressure increase (LVdp/dtmax), end-systolic elastance (Ees), and preload recruitable stroke work (PRSW) (conductance catheter, pressure-volume relationship). Measurements perfusion oxygenation (radioactive microsphere technique) assured comparability model to previously performed studies....
Acute normovolemic hemodilution (ANH) is efficient in reducing allogenic blood transfusion needs during elective surgery. Tissue oxygenation maintained by increased cardiac output and oxygen extraction and, presumably, a more homogeneous tissue perfusion. The aim of this study was to investigate flow distribution skeletal muscle. ANH from hematocrit 36 +/- 3 20 1% performed 22 splenectomized, anesthetized beagles (17 analyzed) ventilated with room air. Normovolemia confirmed measurement...
To design an animal model of ischemia-reperfusion (I/R) in kidneys and evaluate the role that predetermined ranges local hypothermia plays on markers stress-oxydative as well histologic sections.Twenty eight male rats Wistar, under general anesthesia, undergone right nephrectomy (G0, control group) followed by left kidney ischemia during 40 min. Four temperatures groups were designed, with seven animals randomized for each group: normothermic (G1, ±37ºC), mild (G2, 26ºC), moderate (G3, 15ºC)...
Background Hemoglobin solutions combine volume effect, oxygen-carrying capacity, and vasoactive properties, the latter facilitating restoration of global hemodynamics but endangering microvascular resuscitation. Hemoglobin-evoked vasoconstriction probably is due to nitric oxide scavenging, which can be reduced by genetic modifications heme pocket. This study compares resuscitation with a nonhemoglobin colloid two recombinant hemoglobin wild-type oxide-scavenging capacity. Methods...
Topical hypothermia (TH) and ischemic preconditioning (IPC) are used to decrease I/R injury. The efficacy of isolated or combined use TH IPC in the liver regarding inflammation cytoprotection early ischemia/reperfusion (I/R) injury needs be evaluated.Wistar rats underwent 70% ischemia for 90 min followed by 120 reperfusion. Livers animals allocated sham, normothermic (NI), IPC, TH, TH+IPC groups were collected molecular analyses ELISA Western blot, aiming compare proinflammatory,...
PURPOSE: To evaluate the effects of topical liver hypothermia and IPC combination against I/R injury after initial reperfusion. METHODS: In 32 Wistar rats, partial ischemia was induced for 90 minutes in normothermia (IN), ischemic preconditioning (IPC), 26ºC (H) plus (H+IPC). MAP, body temperature bile flow were recorded each 15 minutes. Plasmatic markers tissue antioxidant defenses assessed 120 RESULTS: MAP remained constant during all experiment. Bile returned to levels similar controls 45...
[Purpose] The aim of the present study was to assess knowledge spine and posture among adolescent female students determine if they had access postural education in or outside school. [Subjects Methods] This an epidemiological survey a representative sample 495 aged 14 18 years attending regular secondary school São Leopoldo, RS, Brazil. Data were collected through questionnaire. [Results] results showed that 16.8% teens did not know what was, 8.3% no posture, 61% reported receiving...
Abstract Objective: To estimate the prevalence of back pain in adolescent girls, and determine whether this is associated with socioeconomic, demographic, anthropometric, behavioral factors. Methods: This was an epidemiological survey a representative sample 495 female high school students, aged 14 to 18 years, municipality São Leopoldo southern Brazilian state Rio Grande do Sul. Data were collected through self-administered questionnaire closed, standardized, coded, tested questions....
Endotoxin has profound effects on nitric oxide (NO) production, and considerable controversies exist as to whether these alterations are beneficial or deleterious. Increased mortality been reported from nonselective inhibition of NO synthase. Results selective the inducible isoform (iNOS) appear largely positive. In a model rat endotoxemia we have compared early hepatic morphology function inhibition. Two hours after endotoxin injection (5 mg/kg intraportally) rats were treated with either...
PEURPOSE: The comparison after 6h of hemorrhagic shock (HS) treatment with NaCl 7.5% (Hypertonic Saline Solution - SSH) or Ringer Lactate (RL) on liver function and integrity. METHODS: Male Wistar rats were submitted to HS (Mean Arterial Pressure MAP= 45 mmHg) during 60 min then treated (SSH, 10% blood loss, n=8) (RL, 400% n=8). After anesthetized, hepatic was assessed by bile flow measurement integrity evaluated determination alanine aminotransferase (ALT) bilirubin activities. RESULTS:...
ABSTRACT Objective: to compare abdominal computer tomography (CT) with isolated serial clinical exam (SCE) in the management of anterior stab wounds. Methods: randomized prospective study performed at Hospital de Pronto Socorro Porto Alegre involving patients wounds without indication immediate laparotomy; were divided two groups: CT group and SCE group, In followed up every 6 hours, Patients submitted after initial evaluation. Results: 66 studied 33 included each Of total, six surgery,...
Turner syndrome is an exclusively female genetic disease caused by complete or partial absence of the second X chromosome. It classically characterized congenital lymphedema, short stature, and gonadal dysgenesis. In addition, associated with several other abnormalities. One them gastrointestinal bleeding, which frequently inflammatory bowel disease, but it can also be vascular lesions such as hemangioma, ectasia, telangiectasia. We report case a patient episode outlining our pathway for...