Alfeu de Medeiros Fleck

ORCID: 0000-0002-0424-6919
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Liver Disease Diagnosis and Treatment
  • Liver Disease and Transplantation
  • Organ Transplantation Techniques and Outcomes
  • Hepatitis C virus research
  • Hepatocellular Carcinoma Treatment and Prognosis
  • Liver physiology and pathology
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Pancreatic and Hepatic Oncology Research
  • Hepatitis B Virus Studies
  • Healthcare Systems and Reforms
  • Folate and B Vitamins Research
  • Body Composition Measurement Techniques
  • Medical Imaging and Pathology Studies
  • MicroRNA in disease regulation
  • Thermoregulation and physiological responses
  • Intestinal Malrotation and Obstruction Disorders
  • Organ Donation and Transplantation
  • Cancer Diagnosis and Treatment
  • Renal Transplantation Outcomes and Treatments
  • Viral-associated cancers and disorders
  • Transplantation: Methods and Outcomes
  • Pediatric Hepatobiliary Diseases and Treatments
  • Alcohol Consumption and Health Effects
  • Infrared Thermography in Medicine
  • Cancer-related molecular mechanisms research

Santa Casa Hospital
2002-2023

Hospital Moinhos de Vento
2021

Santa Casa de Misericórdia de Marília
2020

Irmandade da Santa Casa de Misericórdia de São Paulo
2019

Hospital de Clínicas de Porto Alegre
2019

Hospital Geral de Fortaleza
2017

Universidade Federal do Rio Grande do Sul
2006

Grupo Hospitalar Conceição
2004

A systematic bias against women, resulting from the use of creatinine as a measure renal function, has been identified in Model for End-stage Liver Disease (MELD)-based liver allocation. Correction this by calculation female levels using Modification Diet Renal (MDRD) formula suggested.A cohort 639 cirrhotic candidates first-time transplantation was studied. Creatinine were corrected gender MDRD formula. The accuracy MELD, with or without correction, to predict 3-and 6-month mortality after...

10.1016/s1665-2681(19)31006-3 article EN cc-by-nc-nd Annals of Hepatology 2013-05-01

Introduction. Model for end-stage liver disease (MELD) is an accurate predictor of mortality in patients with cirrhosis, and has been used on allocation Brazil since 2006. However, its impact organ allocation, waiting list post-transplant still poorly characterized. This study aimed to assess the implementation MELD system after transplantation (LT) Southern Brazil. Material methods. Adult chronic primary deceased-donor LT were divided into two cohorts (pre- post-MELD implementation)...

10.1016/s1665-2681(19)31007-5 article EN cc-by-nc-nd Annals of Hepatology 2013-05-01

Abstract Real‐world data evaluating the effectiveness of direct‐acting antivirals (DAAs) in hepatitis C virus (HCV) treatment have been reported from different regions. Our aim was to evaluate and clinical outcomes daclatasvir (DCV) sofosbuvir (SOF) ± ribavirin (RBV) a prospective multicentre cohort study including patients Argentina Brazil who received DCV/SOF RBV for 12 or 24 weeks 2015 2018. Multivariable logistic regression models were carried out identify factors associated with failure...

10.1111/jvh.13148 article EN Journal of Viral Hepatitis 2019-05-29

Liver retransplantation (LReTx) is the therapeutic option for hepatic graft failure. Survival after LReTx poorer than primary liver transplantation. Given organ shortage, it essential to optimize use of this resource.To evaluate rates, indications and patient survival identify factors associated with mortality following LReTx.We conducted a retrospective cohort study all adults undergoing based on registry data from Transplantation Group (Complexo Hospitalar Santa Casa de Porto Alegre),...

10.1016/s1665-2681(19)31300-6 article EN cc-by-nc-nd Annals of Hepatology 2013-11-01

ABSTRACT BACKGROUND: In Brazil, the Model for End-Stage Liver Disease (MELD) score is used to prioritize patients deceased donor liver transplantation (DDLT). Patients with hepatocellular carcinoma (HCC) receive standardized MELD exception points account their cancer risk of mortality, which not reflected by score. OBJECTIVE: To compare DDLT rates between and without HCC in Rio Grande do Sul, Southernmost state Brazil. METHODS - We retrospectively studied 825 on liver-transplant waiting list...

10.1590/s0004-2803.202000000-05 article EN Arquivos de Gastroenterologia 2020-02-01

Liver transplantation is the optimal treatment for patients with early hepatocellular carcinoma and cirrhosis. However, recurs in approximately 15 % of individuals. This study aimed to assess efficacy predictive models recurrence after liver transplantation.

10.1016/j.aohep.2023.101184 article EN cc-by-nc-nd Annals of Hepatology 2023-11-24

PURPOSE: The oxidative stress is an important mechanism responsible for dysfunction after orthotopic liver transplantation (OLT). Glutathione (GSH) low levels cold storage render the grafts vulnerable to reperfusion injury. Aim of this study was evaluate GSH and oxidized glutathione (GSSG) concentrations, hepatocellular injury function in optimal suboptimal human OLT. METHODS: Liver biopsies were taken 33 patients before implant two hours reperfusion, allowing determination GSH, GSSG ratio...

10.1590/s0102-86502006000400007 article EN cc-by Acta Cirúrgica Brasileira 2006-08-01

Cholangiocarcinoma (CC) is a rare tumor that arises from the epithelium of bile ducts. It classified according to anatomic location as intrahepatic, perihilar, and distal. Intrahepatic CC (ICC) in patients with cirrhosis due causes other than primary sclerosing cholangitis. Mixed hepatocellular carcinoma-CC (HCC-CC) neoplasm shows histologic findings both HCC ICC within same mass. Due difficulties arriving at correct diagnosis, eventually undergo liver transplantation (LT) presumptive...

10.5306/wjco.v13.i8.688 article EN World Journal of Clinical Oncology 2022-08-23

Little is known about current practice of liver transplantation (LT) in Latin American countries (LATAM). This study aimed to describe LT activity, immunosuppression protocols and policies regarding prophylaxis cytomegalovirus (CMV) infection hepatitis B virus (HBV) recurrence different active LATAM centers. A web-based survey with 20 questions was sent all members ALEH SIG December 2022. 22 centers performing 35 [5-160] per year from Brazil (n=5), Argentina (n=4), Chile Ecuador (n-2),...

10.1016/j.aohep.2023.101257 article EN cc-by-nc-nd Annals of Hepatology 2024-02-01

The introduction of the everolimus as immunosuppressant in liver transplantation has been shown to be safe and effective prophylaxis preservation renal function. Prospective follow-up chart analysis transplant patients treated with was performed. Purpose: To highlight importance pharmacist centers. Method: Along study, 93 were included, being 72 under active treatment. successful treatment depends on multidisciplinary follow-up, it is extremely important involvement patient, making him...

10.53855/bjt.v20i2.80 article EN cc-by Brazilian Journal of Transplantation 2017-03-01

Hepatocellular recurrence after liver transplantation (LTx) is a major cause of morbidity and mortality. We aimed to investigate the association between waiting time hepatocellular carcinoma (HCC) in patients undergoing LTx for HCC. studied 250 who underwent 2007-2015. Survival curves were calculated according Kaplan–Meier method compared by log-rank test. Univariate hazard ratios predictors post-LTx HCC determined Cox proportional hazards regressions. There no significant differences rates...

10.48018/rmv301.2 article EN Revista Medica Vozandes 2019-11-01
Coming Soon ...