A5043964549- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Liver Disease and Transplantation
- Health Systems, Economic Evaluations, Quality of Life
- Hepatitis Viruses Studies and Epidemiology
- Viral-associated cancers and disorders
- Food Security and Health in Diverse Populations
- Whipple's Disease and Interleukins
- Nutritional Studies and Diet
- HIV/AIDS oral health manifestations
- Histiocytic Disorders and Treatments
- Long-Term Effects of COVID-19
- Healthcare cost, quality, practices
- Oral and Craniofacial Lesions
- Biochemical and Molecular Research
- Nail Diseases and Treatments
- Parasitic Diseases Research and Treatment
- Liver Diseases and Immunity
- Nutrition and Health in Aging
Hospital Nossa Senhora da Conceição
2014-2025
Universidade Federal de Ciências da Saúde de Porto Alegre
2015-2025
Hospital de Clínicas de Porto Alegre
2019
University of Nebraska–Lincoln
2016
Universidade Federal do Rio Grande do Sul
2008-2011
Although Candida albicans is the main cause of fungal esophagitis, other species such as C. tropicalis, krusei and stellatoidea have also been implicated. Several studies identified risk factors for esophagitis. However, data non-C. still sparse. The aim this study was to determine etiology esophagitis in our medical centre over an 18-month period. Additionally, we aimed investigate predisposing conditions esophageal candidosis caused by different species. A total 21,248 upper gastroscopies...
Background Nucleoside/nucleotide analogue (NA) treatment causes selection pressure for HBV strains carrying mutations conferring NA resistance. Drug-resistance occur in the reverse transcriptase (RT) region of polymerase gene and spontaneously arise during viral replication. These can also alter hepatitis B surface (HBs) protein some cases reduce binding to HBs antibodies. The spread NA-resistant may impact efficacy antiviral immunization programmes. In this study, we used direct sequencing...
AIMTo evaluate the occurrence of resistant mutations in treatment-naïve hepatitis C virus (HCV) sequences deposited European database (euHCVdb). METHODSThe were downloaded from euHCVdb (https://euhcvdb.ibcp.fr/euHCVdb/).The search was performed for full-length NS3 protease, NS5A and NS5B polymerase HCV, separated by genotypes 1a, 1b, 2a, 2b 3a, resulted 798 NS3, 708 535 HCV 8910 October 28, 2016|Volume 22|Issue 40| WJG|www.wjgnet.com
To assess the incidence of hepatocellular carcinoma (HCC) in chronic liver disease due to hepatitis B virus (HBV) or C (HCV) coinfected with human immunodeficiency (HIV).A retrospective cohort study was performed, including patients HBV HCV, and without HIV coinfection. Patients were selected largest tertiary public hospital complex southern Brazil between January 2007 June 2014. We assessed demographic clinical data, lifestyle habits such as illicit drug use alcohol abuse, addition...
Chromoblastomycosis is a chronic human melanized fungi infection of the subcutaneous tissue caused by traumatic inoculation specific group dematiaceous through skin, often found in barefooted agricultural workers, tropical and subtropical climate countries. We report case male patient presenting slow-growing pruriginous lesion on limbs for 20 years, mistreated over that time, which was diagnosed successfully treated as chromoblastomycosis. Besides prevalence this disease, treatment still...
Background and rationale. The liver biopsy has been considered the gold standard for diagnosis quantification of fibrosis. However, this method presents limitations. In addition, non-invasive evaluation fibrosis is a challenge. aim study was to validate cirrhosis index (FCI) in cohort human immunodeficiency virus (HIV)/hepatitis C (HCV) coinfected patients, compare AST/ALT ratio (AAR), AST platelet (APRI) FIB-4 scores, as tool assessment patients. Material methods. Retrospective cross...
Abstract Real‐world data evaluating the effectiveness of direct‐acting antivirals (DAAs) in hepatitis C virus (HCV) treatment have been reported from different regions. Our aim was to evaluate and clinical outcomes daclatasvir (DCV) sofosbuvir (SOF) ± ribavirin (RBV) a prospective multicentre cohort study including patients Argentina Brazil who received DCV/SOF RBV for 12 or 24 weeks 2015 2018. Multivariable logistic regression models were carried out identify factors associated with failure...
Development of resistance results from mutations in the viral genome, and presence selective drug pressure leads to emergence a resistant virus population. The aim this study was analyze impact genetic variability on barrier DAAs.The quantified based number type nucleotide required impart resistance, considering full-length HCV NS3, NS5A NS5B regions segregated by genotype into subtypes 1a, 1b, 2a, 2b 3a. This analyzeds 789 NS3 sequences, 708 sequences 536 deposited European Hepatitis C...
Saccharomyces species are emerging opportunistic fungal pathogens that can cause bloodstream infections in humans. These have often been associated with the ingestion of probiotics. oesophagitis is a rare condition which has described so far only two publications. Here we report case patient who was diagnosed oesophagitis. The clinical picture indistinguishable from Candida isolate shown to be susceptible fluconazole by both CLSI M27-A and disk diffusion methods. In contrast cases fungaemia,...
Introduction: Liver disease caused by hepatitis C virus (HCV) is a major cause of morbidity in HIV patients. This study investigates the possibility that chronic HCV increases risk hepatotoxicity after highly active antiretroviral therapy (HAART) initiation. Methodology: The data from 30 coinfected HIV/HCV and 35 monoinfected patients between August 2008 2010, since start HAART, were analyzed along with every three months, clinical/laboratory evaluation until end twelve months. aim this was...
Abstract Background Antiretroviral therapy (ART) initiation during acute and early human immunodeficiency virus infection (AEHI) limits HIV reservoir formation may facilitate post-ART control but is logistically challenging. We evaluated the performance of AEHI diagnostic criteria from a prospective study ART initiation. Methods AIDS Clinical Trials Group A 5354 enrolled adults at 30 sites in Americas, Africa, Asia who met any 1 6 based on combinations results RNA, antibody, Western blot or...
BACKGROUND The human immunodeficiency virus (HIV) continuum of care cascade illustrates the 90-90-90 goals defined by Joint United Nations Program on HIV/acquired syndrome (UNAIDS). includes following five steps: Diagnosis, linkage to care, retention in adherence antiretroviral therapy (ART), and viral suppression. AIM To elaborate HIV patients diagnosed with at Nossa Senhora da Conceição Hospital (HNSC) determine possible local causes for loss between each step cascade. METHODS This...
To evaluate the influence of hepatitis C virus on immunological and virological responses after highly active antiretroviral therapy initiation in human immunodeficiency virus/hepatitis coinfected patients compared to monoinfected virus-infected patients. The study enrolled 65 virus-1-infected subjects who initiated attended follow-up visits over 48 weeks from 2008 2010. They were grouped based virus-RNA results. Virological monitored at baseline end 12, 24, 36, 48. There 35 30 In present...
INTRODUÇÃO: O impacto da terapia antirretroviral altamente ativa na progressão fibrose hepática em pacientes co-infectados com HIV e hepatite C não está totalmente esclarecido. Marcadores não-invasivos de podem ser considerados promissores no estadiamento monitorização sua evolução. MÉTODOS: Um total 24 pacientes, divididos dois grupos: 12 monoinfectados por HCV foram acompanhados julho 2008 a agosto 2009, desde o início HAART, cada três meses, avaliação dados clínicos, epidemiológicos...
Infection by hepatitis B virus (HBV) is a worldwide public health problem. Chronic HBV infection with high viral replication may lead to cirrhosis and/or hepatocellular carcinoma. Mutant strains, such as the A1762T/G1764A double mutant, have been associated poor prognosis and higher risk of patient for developing This study analyzed presence mutant in patients chronic its association clinical parameters load, aminotransferases, antigens. A total 49 were included study, strain was detected...
The Choosing Wisely Initiative aims to collect statements from medical societies all over the world on interventions that result in no benefit patients, with potential cause harm. In this article we present views of Diagnostic Laboratory Group at Brazilian Society Infectious Diseases (SBI). Ten experts SBI were asked list 10 diagnostic tests perceived as unnecessary field infectious diseases. After voting for more relevant topics, a questionnaire was sent members, order select most important...
Due to the high prevalence of co-infection by hepatitis C virus (HCV) and human immunodeficiency (HIV) severity these infections, understanding biological mechanisms involved in processes, including viral behavior host genetic profile, is great importance for patient treatment public health policies.Some single nucleotide polymorphisms (SNPs) genome, such as SNP rs1045642 (C3435T) MDR1 gene, have been reported be associated sustained virological response (SVR) HCV HCV-HIV co-infected...
Introduction: Many patients coinfected with the human immunodeficiency virus (HIV) and hepatitis C (HCV) are using highly active antiretroviral therapy (HAART) HCV peginterferon (PEG-IFN) ribavirina (RBV) because use of direct-acting antivirals is not a reality in some countries. To know impact such medications sustained virological response (SVR) during treatment great importance. Methodology: This was retrospective cohort study 215 HIV/HCV patients. The were treated PEG-IFN RBV between...
Primary sclerosing cholangitis (PSC) is a chronic and progressive immune-mediated cholangiopathy causing biliary tree inflammation scarring, leading to liver cirrhosis end-stage disease. Diagnosis of PSC challenging due its nonspecific symptoms overlap with other diseases. Despite the rising incidence PSC, there no proven medical therapy that can alter natural history While transplantation (LT) most effective approach for managing advanced disease caused by post-transplantation recurrence...
INTRODUCTION: Validation of food frequency questionnaires (FFQs) is recommended for accurate measurement habitual consumption. We assessed the relative validity a FFQ in patients coinfected with hepatitis C virus and human immunodeficiency virus. METHODS: Each patient responded to three 24-hour recalls. Pearson’s correlation weighted Kappa index analyses were performed identify concordance. RESULTS: De-attenuated coefficients ranged from 0.35 (vitamin B1) 0.81 (selenium). The concordance...