A5054840982- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- HIV, Drug Use, Sexual Risk
- Opioid Use Disorder Treatment
- Hepatitis B Virus Studies
- Substance Abuse Treatment and Outcomes
- HIV/AIDS Research and Interventions
- COVID-19 epidemiological studies
- Health Policy Implementation Science
- HIV/AIDS drug development and treatment
- Information and Cyber Security
- Data Management and Algorithms
- Prenatal Substance Exposure Effects
- Tuberculosis Research and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- HIV-related health complications and treatments
- Healthcare Policy and Management
- Long-Term Effects of COVID-19
- Health Systems, Economic Evaluations, Quality of Life
- Liver Disease and Transplantation
- Data Visualization and Analytics
- Diagnosis and treatment of tuberculosis
- Homelessness and Social Issues
- Transportation and Mobility Innovations
Boston University
2016-2025
Boston Medical Center
2016-2025
Vilnius University
2004-2024
Association Clinique et Thérapeutique Infantile du Val de Marne
2023-2024
Bio Products Laboratory (United Kingdom)
2023
Vidzeme University of Applied Sciences
2023
Jabil (United States)
2023
Mbarara University of Science and Technology
2023
Creative Commons
2023
Boston Public Schools
2015-2022
Recognizing the importance of timely guidance regarding rapidly evolving field hepatitis C management, American Association for Study Liver Diseases (AASLD) and Infectious Society America (IDSA) developed a web-based process expeditious formulation dissemination evidence-based recommendations. Launched in 2014, virus (HCV) website undergoes periodic updates as necessitated by availability new therapeutic agents and/or research data. A major update was released electronically September 2017,...
Importance Immune dysregulation contributes to poorer outcomes in COVID-19. Objective To investigate whether abatacept, cenicriviroc, or infliximab provides benefit when added standard care for COVID-19 pneumonia. Design, Setting, and Participants Randomized, double-masked, placebo-controlled clinical trial using a master protocol immunomodulators treatment of participants hospitalized with The results 3 substudies are reported from 95 hospitals at 85 research sites the US Latin America....
Introduction The COVID-19 pandemic revealed glaring problems with clinical research enterprise. Faced crisis, several trials opened rapidly but enrolled homogenous populations few Black, Indigenous, and People of Color (BIPOC) individuals. Inclusive trial enrollment is important to inspire trust confidence in BIPOC that have been historically excluded or harmed from improve the generalizability findings. Safety-net hospitals institutions often care for populations, thus it essential...
To improve the effectiveness of tuberculosis (TB) control programs in United States by identifying cost-effective priorities for screening latent infection (LTBI).To estimate cost-effectiveness LTBI using tuberculin skin test (TST)and interferon-g release assays (IGRAs).A Markov model with TST and IGRA risk-groups considered current guidelines.In all risk-groups, resulted increased mean life expectancy, ranging from 0.03–0.24 life-months per person screened. greater expectancy gains than...
To estimate the annual prevalence of opioid use disorder (OUD) in Massachusetts from 2011 to 2015.We performed a multisample stratified capture-recapture analysis OUD Massachusetts. Individuals identified 6 administrative databases for 2012 and 7 2013 2015 were linked at individual level included analysis. by age group, sex, county residence.The among people aged 11 years or older was 2.72% 2.87% 2012. Between 2015, increased 3.87% 4.60%. The greatest increase observed those youngest group...
Despite the growing opioid overdose crisis, medication treatment for use disorder remains uncommon. The comparative effectiveness of buprenorphine and naltrexone in reducing risks discontinuing real world, remain uncertain. Our aim was to examine medications preventing opioid-related overdose.
As highly effective hepatitis C virus (HCV) therapies emerge, data are needed to inform the development of interventions improve HCV treatment rates. We used simulation modeling estimate impact loss follow-up on outcomes and identify intervention strategies likely provide good value for resources invested in them.We a Monte Carlo state-transition model simulate hypothetical cohort chronically HCV-infected individuals recently screened positive serum antibody. simulated four (linkage care;...
Opioid overdose deaths remain high in the U.S. Despite having effective interventions to prevent deaths, there are numerous barriers that impede their adoption. The primary aim of HEALing Communities Study (HCS) is determine impact an intervention consisting community-engaged, data-driven selection, and implementation integrated set evidence-based practices (EBPs) on reducing opioid deaths.The HCS a four year multi-site, parallel-group, cluster randomized wait-list controlled trial. (n = 67)...
Background: Chronic infection with hepatitis C virus (HCV) genotype 2 or 3 can be treated sofosbuvir without interferon. Because is costly, its benefits should compared the additional resources used. Objective: To estimate cost-effectiveness of sofosbuvir-based treatments for HCV in United States. Design: Monte Carlo simulation, including deterministic and probabilistic sensitivity analyses. Data Sources: Randomized trials, observational cohorts, national health care spending surveys. Target...
Coronavirus disease 2019 (COVID-19) will have a lasting impact on public health. In addition to the direct effects of COVID-19 infection, physical distancing and quarantine interventions indirect While necessary, control spread could multiple impacts people living with opioid use disorder, including mental health that lead greater substance use, availability drug supply, ways drugs, treatment-seeking behaviors, retention in care. The degree which epidemic through possible mechanisms we...
<h3>Importance</h3> Although hospitalizations for injection drug use–associated infective endocarditis (IDU-IE) have increased during the opioid crisis, utilization of and mortality associated with receipt medication use disorder (MOUD) after discharge from hospital among patients IDU-IE are unknown. <h3>Objective</h3> To assess proportion receiving MOUD hospitalization association mortality. <h3>Design, Setting, Participants</h3> This retrospective cohort study used a population registry...
During the COVID-19 pandemic, forecasting trends to support planning and response was a priority for scientists decision makers alike. In United States, coordinated by large group of universities, companies, government entities led Centers Disease Control Prevention US Forecast Hub ( https://covid19forecasthub.org ). We evaluated approximately 9.7 million forecasts weekly state-level cases predictions 1–4 weeks into future submitted 24 teams from August 2020 December 2021. assessed coverage...
High hepatitis C virus (HCV) rates have been reported in young people who inject drugs (PWID). We evaluated the clinical benefit and cost-effectiveness of testing among youth seen communities with a high overall number HCV cases. developed decision analytic model to project quality-adjusted life years (QALYs), costs (2016 US$), incremental ratios (ICERs) 9 strategies for 1-time 15- 30-year-olds at urban community health centers. Strategies differed 3 ways: targeted vs routine testing, rapid...
<h3>Importance</h3> The United States is experiencing a crisis of opioid overdose. In response, the US Department Health and Human Services has defined goal to reduce overdose mortality by 40% 2022. <h3>Objective</h3> To identify specific combinations 3 interventions (initiating more people medications for use disorder [MOUD], increasing 6-month retention with MOUD, naloxone distribution) associated at least reduction in simulated populations. <h3>Design, Setting, Participants</h3> This...
Vaccines are a strong public health tool to protect against severe disease, hospitalization, and death from COVID-19. Still, inequities in COVID-19 vaccination rates outcomes continue exist among Black Latino populations. Boston Medical Center (BMC) has played significant role vaccinating medically underserved populations, organized series of community-engaged conversations better understand community concerns regarding the vaccine. This paper describes themes which resulted these proposes...