A5038177258- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- COVID-19 epidemiological studies
- Health Systems, Economic Evaluations, Quality of Life
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Global Cancer Incidence and Screening
- Cervical Cancer and HPV Research
- Healthcare Policy and Management
- Alcohol Consumption and Health Effects
- Colorectal and Anal Carcinomas
- Advanced Causal Inference Techniques
- Economic and Financial Impacts of Cancer
- Data-Driven Disease Surveillance
- Vaccine Coverage and Hesitancy
- AI in cancer detection
- Bariatric Surgery and Outcomes
- HIV/AIDS drug development and treatment
- SARS-CoV-2 and COVID-19 Research
- Viral-associated cancers and disorders
- Systemic Lupus Erythematosus Research
- Chronic Lymphocytic Leukemia Research
- Colorectal Cancer Screening and Detection
- Lymphoma Diagnosis and Treatment
Massachusetts General Hospital
2016-2025
Harvard University
2016-2025
Center for Assessment
2015-2024
Dana-Farber/Harvard Cancer Center
2023
University of Maryland, Baltimore
2023
National Bureau of Economic Research
2023
The University of Texas Southwestern Medical Center
2022
Georgia Institute of Technology
2016-2022
University of Michigan
2017-2022
Systems Analytics (United States)
2022
Sofosbuvir and ledipasvir, which have recently been approved for treatment of chronic hepatitis C virus (HCV) infection, are more efficacious safer than the old standard care (oSOC) but substantially expensive. Whether in patients their improved efficacy justifies increased cost is unclear.
IMPORTANCEDeaths due to opioid overdose have tripled in the last decade.Efforts curb this trend focused on restricting prescription supply; however, near-term effects of such efforts are unknown.OBJECTIVE To project interventions lower misuse deaths from 2016 2025.DESIGN, SETTING, AND PARTICIPANTS This system dynamics (mathematical) model US epidemic projected outcomes simulated individuals who engage nonmedical or illicit use 2025.The analysis was performed 2018 by retrospectively...
Abstract Background The COVID-19 pandemic has driven demand for forecasts to guide policy and planning. Previous research suggested that combining from multiple models into a single “ensemble” forecast can increase the robustness of forecasts. Here we evaluate real-time application an open, collaborative ensemble deaths attributable in U.S. Methods Beginning on April 13, 2020, collected combined one- four-week ahead cumulative jurisdictions standardized, probabilistic formats generate...
Importance Obesity is a disease with large socioeconomic burden. Endoscopic sleeve gastroplasty (ESG) minimally invasive endoscopic bariatric procedure wide global adoption. More recently, new weight-loss medications, such as glucagon-like peptide-1 receptor agonists (eg, semaglutide), have attracted increased attention due to their efficacy. However, cost-effectiveness over an extended period compared ESG critical gap that needs be better explored for informed health care decision-making....
Computer models in medical diagnosis are being developed to help physicians differentiate between healthy patients and with disease. These can aid successful decision making by allowing calculation of disease likelihood on the basis known patient characteristics clinical test results. Two most frequently used computer risk estimation logistic regression an artificial neural network. A study was conducted review compare these two models, elucidate advantages disadvantages each, provide...
Purpose Oral targeted therapies represent a significant advance for the treatment of patients with chronic lymphocytic leukemia (CLL); however, their high cost has raised concerns about affordability and economic impact on society. Our objective was to project future prevalence burden CLL in era oral United States. Methods We developed simulation model that evaluated evolving management from 2011 2025: chemoimmunotherapy (CIT) as standard care before 2014, del(17p) relapsed first-line 2016...
The prevalence of hepatitis C virus (HCV) in U.S. prisoners is high; however, HCV testing and treatment are rare. Infected inmates released back into society contribute to the spread general population. Routine screening followed by new therapies may reduce ongoing transmission.To evaluate health economic effect prisons on epidemic society.Agent-based microsimulation model transmission progression disease.Published literature.Population community.30 years.Societal.Risk-based universal...
Oral direct‐acting antivirals (DAAs) represent a major advance in hepatitis C virus (HCV) treatment. Along with recent updates HCV screening policy and expansions insurance coverage, treatment demand the United States is changing rapidly. Our objective was to project characteristics number of people needing antiviral HCV‐associated disease burden era oral DAAs. We used previously developed validated Hepatitis Disease Burden Simulation model (HEP‐SIM). HEP‐SIM simulated actual clinical...
Background: The burden of human papillomavirus (HPV)–positive oropharyngeal squamous cell carcinoma (OPSCC) is disproportionately high among men, yet empirical evidence regarding the difference in prevalence oral HPV infection between men and women limited. Concordance genital unknown. Objective: To determine infection, as well concordance U.S. women. Design: Nationally representative survey. Setting: Civilian noninstitutionalized population. Participants: Adults aged 18 to 69 years from...
Background: Chronic hepatitis C virus (HCV) infection causes a substantial health and economic burden in the United States. With availability of direct-acting antiviral agents, recently approved therapies those under development, 1-time birth-cohort screening, this disease is expected to decrease. Objective: To predict effect new screening on chronic HCV associated outcomes. Design: Individual-level state-transition model. Setting: Existing anticipated for Patients: Total HCV-infected...
BackgroundAlcohol-related liver disease is the leading indication for transplantation in USA. After remaining stable over three decades, number of deaths due to alcohol-related has been increasing as a result increased high-risk drinking. We aimed project trends cirrhosis and USA up 2040 assess effect potential changes alcohol consumption on those trends.MethodsIn this modelling study, we developed multicohort state-transition (Markov) model drinking patterns populations born 1900–2016...
Abstract BACKGROUND: Discriminating malignant breast lesions from benign ones and accurately predicting the risk of cancer for individual patients are crucial to successful clinical decisions. In past, several artificial neural network (ANN) models have been developed cancer‐risk prediction. All studies reported discrimination performance, but not one has assessed calibration, which is an equivalently important measure accurate this study, authors evaluated whether trained on a large...
Alcohol consumption increased during the COVID-19 pandemic in 2020 United States. We projected effect of alcohol on alcohol-associated liver disease (ALD) and mortality.
Coronavirus disease 2019 (COVID-19) will have a lasting impact on public health. In addition to the direct effects of COVID-19 infection, physical distancing and quarantine interventions indirect While necessary, control spread could multiple impacts people living with opioid use disorder, including mental health that lead greater substance use, availability drug supply, ways drugs, treatment-seeking behaviors, retention in care. The degree which epidemic through possible mechanisms we...
The availability of oral direct‐acting antivirals has altered the hepatitis C virus (HCV) treatment paradigm for both pre–liver transplant (LT) and post‐LT patients. There is a perceived trade‐off between pre‐LT versus HCV—treatment may improve liver function but potentially decrease likelihood necessary LT. Our objective was to identify LT‐eligible patients with decompensated cirrhosis who would benefit (and not benefit) from based on their Model End‐Stage Liver Disease (MELD) scores. We...
Undiagnosed atrial fibrillation (AF) is an important cause of stroke. Screening for AF using wrist-worn wearable devices may prevent strokes, but their cost-effectiveness unknown.To evaluate the contemporary screening strategies, particularly devices.This economic evaluation used a microsimulation decision-analytic model and was conducted from September 8, 2020, to May 23, 2022, comprising 30 million simulated individuals with age, sex, comorbidity profile matching US population aged 65...
Importance In 2021, more than 80 000 US residents died from an opioid overdose. Public health intervention initiatives, such as the Helping to End Addiction Long-term (HEALing) Communities Study (HCS), are being launched with goal of reducing opioid-related overdose deaths (OODs). Objective To estimate change in projected number OODs under different scenarios duration sustainment interventions, compared status quo. Design, Setting, and Participants This decision analytical model simulated...
During the COVID-19 pandemic, forecasting trends to support planning and response was a priority for scientists decision makers alike. In United States, coordinated by large group of universities, companies, government entities led Centers Disease Control Prevention US Forecast Hub ( https://covid19forecasthub.org ). We evaluated approximately 9.7 million forecasts weekly state-level cases predictions 1–4 weeks into future submitted 24 teams from August 2020 December 2021. assessed coverage...
Breast cancer is the most common non-skin affecting women in United States, where every year more than 20 million mammograms are performed. biopsy commonly performed on suspicious findings to confirm presence of cancer. Currently, 700,000 biopsies annually U.S.; 55%-85% these ultimately found be benign breast lesions, resulting unnecessary treatments, patient anxiety, and expenditures. This paper addresses decision problem faced by radiologists: When should a woman sent for based her...
Background & aims Availability of directly-acting antivirals (DAAs) has changed the treatment landscape hepatitis C virus (HCV) infection. The high price DAAs restricted their use in several countries. However, some countries such as India, generic are available at much cheaper price. This study examined whether could be cost-saving and how long it would take for to become cost-saving/effective. Methods A previously-validated, mathematical model was adapted HCV-infected population India...
Nonalcoholic steatohepatitis (NASH) affects 2%‐3% of the US population and is expected to become leading indication for liver transplantation in next decade. Bariatric surgery may be an effective but expensive treatment NASH. Using a state‐transition model, our analysis assessed effectiveness cost‐effectiveness manage We simulated benefits harms laparoscopic Roux‐en‐Y gastric bypass patients defined by weight class (overweight, mild obesity, moderate severe obesity) fibrosis stage (F0‐F3)....