A5043501566- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Mosquito-borne diseases and control
- Global Cancer Incidence and Screening
- Colorectal Cancer Surgical Treatments
- Diverticular Disease and Complications
- Viral Infections and Vectors
- Health Systems, Economic Evaluations, Quality of Life
- Pancreatic and Hepatic Oncology Research
- Economic and Financial Impacts of Cancer
- Esophageal Cancer Research and Treatment
- Zoonotic diseases and public health
- Ovarian cancer diagnosis and treatment
- Intraperitoneal and Appendiceal Malignancies
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Infant Development and Preterm Care
- demographic modeling and climate adaptation
- Colorectal and Anal Carcinomas
- Neonatal Respiratory Health Research
- Radiation Dose and Imaging
- Insect and Pesticide Research
- Opioid Use Disorder Treatment
- Renal cell carcinoma treatment
Massachusetts General Hospital
2015-2025
Harvard University
2007-2025
Center for Assessment
2009-2024
Cleveland Clinic
2018
Kaiser Permanente Washington Health Research Institute
2010-2016
National Cancer Institute
2011-2016
Memorial Sloan Kettering Cancer Center
2008-2016
RAND Corporation
2016
University of Washington
2016
Erasmus MC
2010-2014
Background: The U.S. Preventive Services Task Force requested a decision analysis to inform their update of recommendations for colorectal cancer screening. Objective: To assess life-years gained and colonoscopy requirements screening strategies identify set recommendable strategies. Design: Decision using 2 microsimulation models from the Cancer Intervention Surveillance Modeling Network. Data Sources: Derived literature. Target Population: average-risk 40-year-old population. Perspective:...
The US Preventive Services Task Force (USPSTF) is updating its 2008 colorectal cancer (CRC) screening recommendations.
IMPORTANCEDeaths due to opioid overdose have tripled in the last decade.Efforts curb this trend focused on restricting prescription supply; however, near-term effects of such efforts are unknown.OBJECTIVE To project interventions lower misuse deaths from 2016 2025.DESIGN, SETTING, AND PARTICIPANTS This system dynamics (mathematical) model US epidemic projected outcomes simulated individuals who engage nonmedical or illicit use 2025.The analysis was performed 2018 by retrospectively...
<h3>Importance</h3> The US Preventive Services Task Force (USPSTF) is updating its 2016 colorectal cancer screening recommendations. <h3>Objective</h3> To provide updated model-based estimates of the benefits, burden, and harms strategies to identify that may an efficient balance life-years gained (LYG) from colonoscopy burden inform USPSTF. <h3>Design, Setting, Participants</h3> Comparative modeling study using 3 microsimulation models in a hypothetical cohort 40-year-old individuals at...
Background & AimsA blood-based colorectal cancer (CRC) screening test may increase participation. However, blood tests be less effective than current guideline-endorsed options. The Centers for Medicare Medicaid Services (CMS) covers with sensitivity of at least 74% detection CRC and specificity 90%. In this study, we investigate whether a that meets these criteria is cost-effective.MethodsThree microsimulation models (MISCAN-Colon, CRC-SPIN, SimCRC) were used to estimate the effectiveness...
Abstract Background: Considerable disparities exist in colorectal cancer (CRC) incidence and mortality rates between blacks whites the United States. We estimated how much of these could be explained by differences CRC screening stage-specific relative survival. Methods: used MISCAN-Colon microsimulation model to estimate blacks, aged 50 years older, from 1975 2007 assuming they had: (i) same trends as instead observed (incidence mortality); (ii) survival (mortality only); (iii) a...
Background: Harms and benefits of cancer screening depend on age comorbid conditions, but reliable estimates are lacking. Objective: To estimate the harms by conditions to inform decisions about cessation. Design: Collaborative modeling with 7 simulation models common data average condition level–specific life expectancy. Setting: U.S. population. Patients: cohorts aged 66 90 years in 2010 health or 1 4 levels: none, mild, moderate, severe. Intervention: Mammography, prostate-specific...
Faecal occult blood tests (FOBTs) are used for colorectal cancer (CRC) screening. We aimed to assess the sensitivity of an immunochemical FOBT detecting advanced neoplasia in left vs right colon and explore reasons potential differences site-specific test performance.We prospectively measured faecal levels by a quantitative (RIDASCREEN) 2310 average-risk subjects undergoing screening colonoscopy. compared diagnostic performance with left- right-sided neoplasia, as well patient...
BackgroundThe Centers for Medicare and Medicaid Services (CMS) considered whether to reimburse computed tomographic colonography (CTC) colorectal cancer screening of enrollees. To help inform its decision, we evaluated the reimbursement rate at which CTC could be cost-effective compared with tests that are currently reimbursed by CMS included in most guidelines, namely annual fecal occult blood test (FOBT), flexible sigmoidoscopy every 5 years, years conjunction FOBT, colonoscopy 10 years.
Colorectal cancer (CRC) screening with colonoscopy and the fecal immunochemical test (FIT) is underused. Innovative tests could increase acceptance. This study determined which of available alternatives most promising from a cost-effectiveness perspective.
Importance In 2021, more than 80 000 US residents died from an opioid overdose. Public health intervention initiatives, such as the Helping to End Addiction Long-term (HEALing) Communities Study (HCS), are being launched with goal of reducing opioid-related overdose deaths (OODs). Objective To estimate change in projected number OODs under different scenarios duration sustainment interventions, compared status quo. Design, Setting, and Participants This decision analytical model simulated...
Abstract Background Blood-based biomarker tests can potentially change the landscape of colorectal cancer (CRC) screening. We characterize conditions under which blood test screening would be as effective and cost-effective annual fecal immunochemical testing or decennial colonoscopy. Methods used 3 Cancer Information Surveillance Modeling Network–Colon models to compare scenarios no screening, testing, colonoscopy, a meeting Centers for Medicare & Medicaid (CMS) coverage criteria (74%...
The purpose of this study was to estimate the ratio cancers prevented induced (benefit-risk ratio) for CT colonography (CTC) screening every 5 years from age 50 80 years.Radiation-related cancer risk estimated using projection models based on National Research Council's Biological Effects Ionizing Radiation (BEIR) VII Committee's report and protocols American College Radiology Imaging Network's Colonography Trial. Uncertainty intervals were Monte Carlo simulation methods. Comparative...
Background. As the complexity of microsimulation models increases, concerns about model transparency are heightened. Methods. The authors conducted “experiments” to explore impact variations in “deep” parameters using 3 colorectal cancer (CRC) models. All natural history were calibrated match observed data on adenoma prevalence and incidence but varied their underlying specification adenocarcinoma process. projected CRC among individuals with an or preclinical v. those without any condition...
BackgroundTreatment options for colorectal cancer (CRC) have improved substantially over the past 25 years. Measuring impact of these improvements on survival outcomes is challenging, however, against background overall gains from advancements in prevention, screening, and treatment other conditions. Relative a metric that accounts concurrent changes, allowing assessment changes CRC survival. We describe stage- location-specific trends relative after diagnosis.
BACKGROUND Colorectal cancer (CRC) risk varies by race and sex. This study, 1 of 2 microsimulation analyses to inform the 2018 American Cancer Society CRC screening guideline, explored influence sex on optimal strategies. METHODS Two Intervention Surveillance Modeling Network models, informed US incidence data, were used evaluate a variety methods, ages start stop, intervals for 4 demographic subgroups (black white males females) under scenarios projected lifetime 40‐year‐olds: 1) assuming...
Background In 2014, the Centers for Medicare and Medicaid Services (CMS) began covering a multitarget stool DNA (mtSDNA) test colorectal cancer (CRC) screening of beneficiaries. this study, we evaluated whether mtSDNA testing is cost-effective alternative to other CRC strategies reimbursed by CMS, if not, under what conditions it could be. Methods We use three independently-developed microsimulation models simulate cohort previously unscreened US 65-year-olds who are screened with triennial...
Importance Increased use of recommended screening could help achieve the Cancer Moonshot goal reducing US cancer deaths. Objective To estimate number deaths that be prevented with a 10–percentage point increase in Preventive Services Task Force (USPSTF)-recommended screening. Design, Setting, and Participants This decision analytical model study is an extension previous studies conducted for USPSTF from 2018 to 2023. simulated contemporary cohorts adults eligible lung, colorectal, breast,...