A5026657495- Colorectal Cancer Screening and Detection
- Cervical Cancer and HPV Research
- Gastric Cancer Management and Outcomes
- Global Cancer Incidence and Screening
- Genetic factors in colorectal cancer
- Esophageal Cancer Research and Treatment
- Genital Health and Disease
- Esophageal and GI Pathology
- Hepatitis B Virus Studies
- Reproductive tract infections research
- Pancreatic and Hepatic Oncology Research
- Cancer Risks and Factors
- Health Systems, Economic Evaluations, Quality of Life
- Pancreatitis Pathology and Treatment
- Influenza Virus Research Studies
- Respiratory viral infections research
- Cancer Genomics and Diagnostics
- Endometrial and Cervical Cancer Treatments
- Diverticular Disease and Complications
- Eosinophilic Esophagitis
- Colorectal Cancer Surgical Treatments
- Ethics in Clinical Research
- Game Theory and Voting Systems
- Clinical practice guidelines implementation
- Transportation Planning and Optimization
Erasmus MC
2014-2023
Centraal Bureau voor de Statistiek
2020-2022
University Medical Center Utrecht
2019-2020
The Royal Melbourne Hospital
2017
Amsterdam UMC Location Vrije Universiteit Amsterdam
2017
University of Amsterdam
2017
The University of Adelaide
2017
Society for Maternal-Fetal Medicine
2017
Amsterdam UMC Location University of Amsterdam
2017
Memorial Sloan Kettering Cancer Center
2016
The US Preventive Services Task Force (USPSTF) is updating its 2008 colorectal cancer (CRC) screening recommendations.
Background In 2014, the Centers for Medicare and Medicaid Services (CMS) began covering a multitarget stool DNA (mtSDNA) test colorectal cancer (CRC) screening of beneficiaries. this study, we evaluated whether mtSDNA testing is cost-effective alternative to other CRC strategies reimbursed by CMS, if not, under what conditions it could be. Methods We use three independently-developed microsimulation models simulate cohort previously unscreened US 65-year-olds who are screened with triennial...
Within the last decade, SurePath and ThinPrep [both liquid-based cytology (LBC) tests] have replaced conventional (CC) as primary test method in cervical cancer screening programs of multiple countries. The aim our study was to examine effect Dutch program. All smears taken within this program from 2000 2011 were analyzed using nationwide registry histo- cytopathology (PALGA) with a follow-up until March 2013. percentage classified borderline/mildly dyskaryotic (BMD) >BMD well CIN detection...
Although uniform colonoscopy screening reduces colorectal cancer (CRC) mortality, risk-based may be more efficient. We investigated whether CRC based on polygenic risk is a cost-effective alternative to current screening, and if not, under what conditions it would be.The MISCAN-Colon model was used simulate hypothetical cohort of US 40-year-olds. Uniform modeled as at ages 50, 60, 70 years. For risk-stratified individuals underwent testing with potential future discriminatory performance...
Objective We aim to compare the cost‐effectiveness of old cytology programme with new high‐risk human papillomavirus (hrHPV) screening programme, using performance indicators from Dutch hrHPV programme. Design Model‐based analysis. Setting The Netherlands. Population 30‐year‐old unvaccinated females followed up lifelong. Methods updated microsimulation analysis (MISCAN) model most recent epidemiological and data simulated both programmes, behaviour costs observed in each Sensitivity analyses...
Human papillomavirus (HPV) self-sampling might be a promising tool to increase effectiveness of primary HPV screening programs when offered non-attendees. However, could decrease if regular attendees "switch" self-sampling, because test characteristics may inferior. We examined under which conditions the harms would outweigh benefits.The MISCAN-cervix model was used estimate quality-adjusted life years (QALY) gained and costs offering varied relative CIN2(+) sensitivity specificity...
Vaccination against the oncogenic human papillomavirus (HPV) types 16 and 18 will reduce prevalence of these types, thereby also reducing cervical cancer risk in unvaccinated women. This (measurable) herd effect be limited at first, but is expected to increase over time. At a certain immunity level, tailoring screening vaccination status may no longer worth additional effort. Moreover, uniform only viable option. We therefore investigated what level it cost-effective intensity women.We used...
Objective To compare the cumulative incidence of cervical cancer diagnosed within 72 months after a normal screening sample between conventional cytology and liquid based tests SurePath ThinPrep.Design Retrospective population cohort study.Setting Nationwide network registry histo- cytopathology in Netherlands (PALGA), January 2000 to March 2013.Population Women with 5 924 474 samples (23 833 123 person years).Exposure Use or ThinPrep versus as test.Main outcome measure month invasive for...
Abstract Background: There is growing evidence for personalizing colorectal cancer screening based on risk factors. We compared the cost-effectiveness of personalized polygenic and family history to uniform screening. Methods: Using MISCAN-Colon model, we simulated a cohort 100 million 40-year-olds, offering them or Individuals were categorized cancer. varied strategies by start age, interval test estimated costs, quality-adjusted life years (QALY). In our analysis, (i) assessed screening;...
With the implementation of primary high-risk human papillomavirus (hrHPV) screening in Netherlands, an increase was observed number unnecessary referrals (≤Cervical Intraepithelial Neoplasia (CIN) 1) to colposcopy. We aimed investigate which alternative triage strategies safely reduce HPV-based cervical cancer programmes.Microsimulation model MISCAN used simulate unvaccinated cohort ten million 30-year old Dutch women. calculated referrals, incidence, mortality, costs and QALYs for 24...
Estimates on the progression of precursor lesions to pancreatic cancer (PC) are scarce. We used microsimulation modeling gain insight into natural disease course PC and its precursors. This information is pivotal explore efficacy screening.
Current guidelines recommend surveillance for patients with nondysplastic Barrett's esophagus (NDBE) but do not include a recommended age discontinuing surveillance. This study aimed to determine the optimal last of NDBE stratified by sex and level comorbidity.We used 3 independently developed models simulate diagnosed NDBE, varying in age, sex, comorbidity (no, mild, moderate, severe). All had received regular until their current age. We calculated incremental costs quality-adjusted...
Background: Colorectal cancer (CRC) screening is cost-effective in many Western countries, and have successfully implemented CRC programs. For countries with a lower incidence, like Saudi Arabia, the value of less evident requires careful weighing harms, benefits, costs. Methods: We used MISCAN-Colon microsimulation model to simulate male female cohort life expectancy risk as observed Arabia. both cohorts, we evaluated strategies without screening, annual or biennial faecal immunochemical...
Abstract Background and Aim Individuals with Lynch syndrome (LS) are at increased risk of LS‐related cancers including colorectal cancer (CRC). CRC tumor screening for mismatch repair (MMR) deficiency is recommended in Australia to identify LS, although its cost‐effectiveness has not been assessed. We aim determine the individuals LS different age‐at‐diagnosis thresholds. Methods developed a decision analysis model estimate yield costs screening. Age‐specific probabilities diagnosis were...
Background. Microsimulation models are increasingly being used to inform colorectal cancer (CRC) screening recommendations. MISCAN-Colon is an example of such a model, the Dutch CRC program and US Preventive Services Task Force guidelines. Assessing validity these essential provide transparency regarding their performance. In this study, we tested external predictive MISCAN-Colon. Methods. We validated using Norwegian Colorectal Cancer Prevention (NORCCAP) trial, randomized controlled trial...
Objective Over the last decade, cervical intraepithelial neoplasia (CIN) detection has increased in Netherlands. We investigated underlying mechanism by quantifying increase, and analyzing patterns of CIN cancer over time. Methods observed annual rates (DRs) per 10,000 primary smears within Dutch screening programme for 2000–2011. Joinpoint analyses were performed to determine changes time trends, logistic regression assess relative risk calendar on histological outcomes, adjusted...
It is well acknowledged that HPV testing should not be performed at young age and short intervals. Cytological screening practices have shown over-screening, i.e., from a younger shorter intervals than recommended, hard to avoid. We quantified the consequences of switch primary for over-screened women, taking into account its higher sensitivity but lower specificity cytology. The health effects using test instead cytology as method were determined with MISCAN-Cervix model. varied women start...
Background Human papillomavirus (HPV) vaccination and the implementation of primary HPV screening in Netherlands will lead to a lower cervical disease burden. For evaluation further improvement prevention, it is important estimate magnitude timing health benefits current alternative strategies such as boys or adults. Methods findings We evaluated impact girls-only program on burden among first four vaccinated five-year birth cohorts, given context screening. integrated existing...
Expanding routine human papillomavirus (HPV) vaccination to adults could be an effective strategy improve prevention of HPV infection and cervical cancer.We evaluated the following adult strategies for women only both men in addition current girls-only program Netherlands, using established STDSIM microsimulation model: one-time mass campaign, at first cancer screening visit, sexual health clinics, combinations these strategies.The estimated impact expanding is modest, with largest...