A5100338020- Opioid Use Disorder Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Substance Abuse Treatment and Outcomes
- HIV, Drug Use, Sexual Risk
- Liver Disease Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- Prenatal Substance Exposure Effects
- Census and Population Estimation
- Lung Cancer Diagnosis and Treatment
- Ectopic Pregnancy Diagnosis and Management
- HIV Research and Treatment
- Carbohydrate Chemistry and Synthesis
- Acute Ischemic Stroke Management
- Gastric Cancer Management and Outcomes
- Energy, Environment, Economic Growth
- Catalysis and Hydrodesulfurization Studies
- Homelessness and Social Issues
- Inflammatory Myopathies and Dermatomyositis
- Esophageal Cancer Research and Treatment
- Forensic Toxicology and Drug Analysis
- HIV/AIDS Research and Interventions
- Radiomics and Machine Learning in Medical Imaging
- T-cell and B-cell Immunology
- Amyotrophic Lateral Sclerosis Research
Massachusetts General Hospital
2024-2025
Harvard University
2024-2025
Boston Medical Center
2017-2025
Huazhong University of Science and Technology
2021-2025
Qilu University of Technology
2025
Shandong Academy of Sciences
2025
Boston University
2017-2025
Anhui University
2025
Soochow University
2023-2024
Affiliated Hospital of Hebei University
2021-2024
To estimate the annual prevalence of opioid use disorder (OUD) in Massachusetts from 2011 to 2015.We performed a multisample stratified capture-recapture analysis OUD Massachusetts. Individuals identified 6 administrative databases for 2012 and 7 2013 2015 were linked at individual level included analysis. by age group, sex, county residence.The among people aged 11 years or older was 2.72% 2.87% 2012. Between 2015, increased 3.87% 4.60%. The greatest increase observed those youngest group...
Abstract Background & Aims Largazole is a novel histone deacetylase ( HDAC ) inhibitor. This study investigated the effects of largazole against liver fibrosis. Methods The in vitro were examined using hepatic stellate cells HSC s). In vivo studied mouse fibrotic model induced by CC l 4 . Results augmented acetylation H3 (H3) and H4 (H4) HSCs. It directly inhibited activation HSCs owing to inhibitory activity as antifibrotic effect was significantly decreased with HDAC1, HDAC2 HDAC3...
<h3>Importance</h3> The United States is experiencing a crisis of opioid overdose. In response, the US Department Health and Human Services has defined goal to reduce overdose mortality by 40% 2022. <h3>Objective</h3> To identify specific combinations 3 interventions (initiating more people medications for use disorder [MOUD], increasing 6-month retention with MOUD, naloxone distribution) associated at least reduction in simulated populations. <h3>Design, Setting, Participants</h3> This...
Endocarditis, once predominately found in older adults, is increasingly common among younger persons who inject drugs. Untreated opioid use disorder (OUD) complicates endocarditis management. We aimed to determine if rates of overdose and rehospitalization differ between with OUD are initiated on medications for (MOUDs) within 30 days hospital discharge those not.We performed a retrospective cohort study using large commercial health insurance claims database ≥18 years July 1, 2010, June 30,...
The US Centers for Disease Control and Prevention the U.S. Preventive Services Task Force recommend one-time hepatitis C virus (HCV) testing persons born 1945-1965 targeted high-risk persons. This strategy targets HCV to a prevalent population at high risk morbidity mortality, but does not include younger populations with incidence. To address this gap improve access testing, age-based strategies should be considered.We used simulation of estimate effectiveness cost-effectiveness strategies:...
Body roundness index (BRI) is an obesity-related anthropometric that combines waist circumference and height to better reflect body fat. This study aims prospectively explore the relationship between BRI risk of heart failure (HF) based on a community-based cohort.A total 140 362 individuals without tumour HF at baseline were included from Kailuan cohort study. Their demographic information, parameters, biochemical indexes collected or measured. The participants followed up until 31 December...
As overdoses continue to increase worldwide, accurate estimates are needed understand the size of population at risk and address health disparities. Capture-recapture methods may be used in place direct estimation nearly any geographic level (e.g., city, state, country) estimate with opioid use disorder (OUD). We performed a multi-sample capture-recapture analysis persons aged 18-64 years prevalence OUD Massachusetts from 2014 2020, stratified by sex race/ethnicity.
Endotoxemia is a life-threatening situation that signifies key challenge in the field of intensive care medicine. Proinflammatory mediators produced by macrophages play role endotoxemia. Gelsolin (GSN) involved process inflammation.IL-6 and TNF-α supernatant were measured with an ELISA kit. NO production was assessed measurement nitrite concentration Griess assay. si-RNA directed against GSN (si-GSN) transfected Lipofectamine.LPS decreased levels GSN. Recombinant inhibited cytokines induced...
The South China Sea dispute is one of the most complicated geopolitical issues twenty-first century. While this international conflict revolves around military and economic disputes, in today's information age politics also hinges on how each country presents news whose "story" wins. Based Network Agenda Setting model, study analyzed coverage three involved countries—China, Philippines, United States—and examined gains prominence Twitter, an emerging transnational public sphere. A...
Homelessness is a public health crisis in the United States, yet homelessness prevalence, especially among children and youth, not well understood. In this study, we use an indirect estimation method known as multiple systems to further evaluate prevalence of youth experiencing Denver, Colorado. We performed ("capture-recapture") analysis estimate annual aged 14 17 years city county Colorado from 2017 2021. used 3 citywide datasets linked at individual level stratified by year, follows: (1)...
Abstract Design engineering for the preparation of green and inexpensive catalysts assisted by lignocellulosic biomass or biomass‐based derivatives has garnered significant attention. Herein, alkali lignin (AL) is utilized as a carbon precursor to prepare porous coral‐like g‐C 3 N 4 (x% PLCN) with nitrogen defects biochar persistent free radicals (biochar‐PFRs). This catalyst applied photo‐thermal catalysis HMF produce maleic acid (MA). The optimal yield MA (50.43%) achieved using 1.5% PLCN...
The relationships between air pollution, genetic susceptibility, and COVID-19-related outcomes, as well the potential interplays pollution remain largely unexplored. Cox proportional hazards model was used to assess associations long-term exposure pollutants risk of COVID-19 outcomes (infection, hospitalization, death) in a COVID-19-naive cohort (n = 458,396). Additionally, severity (hospitalization were evaluated infection 110,216). Furthermore, this study investigated role host...
Abstract People who inject drugs (PWID) account for the majority of hepatitis C virus (HCV) infections in United States. The injection-equipment-sharing network likely plays an important role shaping dynamics HCV transmission. Recognizing emerging epidemic rural communities, we developed agent-based simulation model transmission via and used data on PWID networks to inform parameterization calibration. We then simulated array that varied key properties understand their impact magnitude...
Background Simulation models of opioid use disorder (OUD) aim at evaluating the impact different treatment strategies on population-level outcomes. Researching Effective Strategies to Prevent Opioid Death (RESPOND) is a dynamic population, state-transition model that simulates Massachusetts OUD population synthesizing data from multiple sources. Structural complexity and scarcity available for modeling pose special challenge calibration. We propose an empirical calibration approach...
With the advancement of internet technology and widespread adoption high-speed network technologies such as 5G, e-commerce platforms have become primary channels for everyday shopping. However, issues "big data price discrimination" predatory pricing emerged during their development, leading to monopolies that harm real economy public interest. This study analyzes legal regulatory framework, fundamental principles, measures, advantages disadvantages concerning monopoly on platforms. It...