A5021278551- Opioid Use Disorder Treatment
- Substance Abuse Treatment and Outcomes
- Pain Management and Opioid Use
- Forensic Toxicology and Drug Analysis
- Pharmacological Effects and Toxicity Studies
- Neurotransmitter Receptor Influence on Behavior
- Poisoning and overdose treatments
- Pharmacological Receptor Mechanisms and Effects
- HIV, Drug Use, Sexual Risk
- Treatment of Major Depression
- Attention Deficit Hyperactivity Disorder
- Electroconvulsive Therapy Studies
- Cannabis and Cannabinoid Research
- Schizophrenia research and treatment
- Neuropeptides and Animal Physiology
- Epilepsy research and treatment
- Prenatal Substance Exposure Effects
- Cancer Treatment and Pharmacology
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Diet and metabolism studies
- Pharmaceutical studies and practices
- Receptor Mechanisms and Signaling
- Nicotinic Acetylcholine Receptors Study
- Pain Mechanisms and Treatments
- Metabolism and Genetic Disorders
University of Kentucky
2016-2025
Poliomyelitis Research Foundation
2024
Delaware County Memorial Hospital
2024
Electric Vehicle Challenge
2024
Walsh University
2019-2024
Boston University
2024
Harvard University
2024
Boston Medical Center
2024
Tufts University
2024
Massachusetts Department of Public Health
2024
Objective The purpose of this study was to characterize the acute effects buprenorphine, an opioid partial (μ-agonist, across a wide range doses in comparison methadone. Method Healthy adult male volunteers, who had experience with but were not physically dependent on opioids, participated while residing closed research unit. Four subjects received buprenorphine (0, 1, 2, 4, 8, 16, and 32 mg sublingually five methadone 15, 30, 45, 60 orally) ascending order at 1-week intervals. Physiologic,...
In a 17-week randomized study of 220 patients, we compared levomethadyl acetate (75 to 115 mg), buprenorphine (16 32 and high-dose (60 100 mg) low-dose (20 methadone as treatments for opioid dependence. Levomethadyl were administered three times week. Methadone was daily. Doses individualized except in the group assigned methadone. Patients with poor responses treatment switched
<h3>Importance</h3> Buprenorphine treatment for opioid use disorder may be improved by sustained-release formulations. <h3>Objective</h3> To determine whether involving novel weekly and monthly subcutaneous (SC) buprenorphine depot formulations is noninferior to a daily sublingual (SL) combination of hydrochloride naloxone in the disorder. <h3>Design, Setting, Participants</h3> This outpatient, double-blind, double-dummy randomized clinical trial was conducted at 35 sites United States from...
This cohort study examines the incidence of precipitated withdrawal comparing traditional sublingual buprenorphine with a 7-day extended-release injectable initiated in emergency department (ED).
Methadone, a gold standard treatment for opioid use disorder, faces limited access due to federal regulations restricting its dispensing licensed programs (OTPs). Transportation is critical barrier reported by rural area residents, where the distances OTPs are over six times farther than urban residents. To overcome this in Kentucky, HEALing (Helping End Addiction Long-term SM ) Communities Study (HCS) partnered with Voices of Hope, local recovery community organization, develop peer...
A RANDOMIZED controlled trial (RCT) is the most reliable method of assessing efficacy health care interventions.<sup>1,2</sup>Reports RCTs should provide readers with adequate information about what went on in design, execution, analysis, and interpretation trial. Such reports will help judge validity There have been several investigations evaluating how are reported. In an early study, Mahon Daniel<sup>3</sup>reviewed 203 drug trials published between 1956 1960 the<i>Canadian Medical...
Buprenorphine, a mixed opioid agonist-antagonist, is being investigated as treatment for dependence. This study compared the acute subjective and physiological effects of sublingual buprenorphine to those p.o. methadone over wide range doses ability both drugs alter an challenge. Male inpatient volunteers (n = 9) with histories abuse participated in this double-blind, double-dummy study. Sublingual (0, 0.5, 2, 8, 16 32 mg) (3.75, 15 60 were administered once weekly according Latin-square...
Opioid overdose deaths remain high in the U.S. Despite having effective interventions to prevent deaths, there are numerous barriers that impede their adoption. The primary aim of HEALing Communities Study (HCS) is determine impact an intervention consisting community-engaged, data-driven selection, and implementation integrated set evidence-based practices (EBPs) on reducing opioid deaths.The HCS a four year multi-site, parallel-group, cluster randomized wait-list controlled trial. (n = 67)...