A5073334486- Health Systems, Economic Evaluations, Quality of Life
- Meta-analysis and systematic reviews
- Statistical Methods in Clinical Trials
- Ethics in Clinical Research
- Health and Medical Research Impacts
- Biomedical Ethics and Regulation
- Cytomegalovirus and herpesvirus research
- Clinical practice guidelines implementation
- HIV Research and Treatment
- Dementia and Cognitive Impairment Research
- Retinal Diseases and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Alzheimer's disease research and treatments
- Sex and Gender in Healthcare
- Inflammatory mediators and NSAID effects
- Diabetes Treatment and Management
- Pharmaceutical Economics and Policy
- Health Sciences Research and Education
- Pharmacology and Obesity Treatment
- Pharmaceutical industry and healthcare
- Delphi Technique in Research
- Treatment of Major Depression
- Schizophrenia research and treatment
- HIV/AIDS Research and Interventions
- Neonatal Respiratory Health Research
Johns Hopkins University
2011-2022
Brigham and Women's Hospital
2022
Queensland University of Technology
2018
National Eye Institute
2002-2008
National Cancer Institute
2008
Statistics Collaborative
2008
University of Washington
1997-2006
Bloomberg (United States)
2006
Johns Hopkins Medicine
2002
National Institutes of Health
2002
Perioperative morbidity may be modifiable in high risk patients by the anesthesiologist's choice of either regional or general anesthesia. This clinical trial compared outcomes between epidural (EA) and (GA) anesthesia/analgesia regimens a group at for cardiac other who were undergoing similarly stressful surgical procedures.One hundred scheduled elective vascular reconstruction lower extremities randomized to receive EA surgery followed analgesia, GA intravenous patient-controlled...
A low CD4/CD8 ratio in elderly HIV-uninfected adults is associated with increased morbidity and mortality. subset of HIV-infected receiving effective antiretroviral therapy (ART) fails to normalize this ratio, even after they achieve normal CD4+ T cell counts. The immunologic clinical characteristics phenotype remain undefined. Using data from four distinct cohorts three trials, we show that a during otherwise ART (after CD4 count recovery above 500 cells/mm3) number immunological...
Agitation is common, persistent, and associated with adverse consequences for patients Alzheimer disease. Pharmacological treatment options, including antipsychotics are not satisfactory.The primary objective was to evaluate the efficacy of citalopram agitation in Key secondary objectives examined effects on function, caregiver distress, safety, cognitive tolerability.The Citalopram Disease Study (CitAD) a randomized, placebo-controlled, double-blind, parallel group trial that enrolled 186...
Background. While inflammation predicts mortality in treated human immunodeficiency virus (HIV) infection, the prognostic significance of gut barrier dysfunction and phenotypic T-cell markers remains unclear. Methods. We assessed immunologic predictors a case-control study within Longitudinal Study Ocular Complications AIDS (LSOCA), using conditional logistic regression. Sixty-four case patients who died 12 months treatment-mediated viral suppression were each matched to 2 control...
Background— Observational studies and randomized trials have reported increased cardiovascular risk associated with cyclooxygenase-2 inhibitors. Prior placebo-controlled had limited ability to assess the relationship of either celecoxib dose or pretreatment status celecoxib. Our aim was in 3 regimens between baseline effect on events. Methods Results— We performed a patient-level pooled analysis adjudicated data from 7950 patients 6 comparing placebo for conditions other than arthritis...
To evaluate the efficacy and safety of naproxen celecoxib for primary prevention Alzheimer disease (AD).Randomized, placebo-controlled, double-masked clinical trial conducted at six US dementia research clinics. Volunteers aged 70+ years, with cognitive screening scores above designated cut-offs a family history AD, were randomly assigned to 200 mg BID, sodium 220 or placebo. Enrollment began in early 2001. The main outcome measure was diagnosis AD after randomization.On December 17, 2004,...
Background Epidemiologic evidence suggests that nonsteroidal anti‐inflammatory drugs (NSAIDs) delay onset of Alzheimer's dementia (AD), but randomized trials show no benefit from NSAIDs in patients with symptomatic AD. The Disease Anti‐inflammatory Prevention Trial (ADAPT) 2528 elderly persons to naproxen or celecoxib versus placebo for 2 years (standard deviation = 11 months) before treatments were terminated. During the treatment interval, 32 cases AD revealed increased rates both...
Injections of allergens are widely prescribed for patients with asthma, but little is known about the effectiveness immunotherapy.
A RANDOMIZED controlled trial (RCT) is the most reliable method of assessing efficacy health care interventions.<sup>1,2</sup>Reports RCTs should provide readers with adequate information about what went on in design, execution, analysis, and interpretation trial. Such reports will help judge validity There have been several investigations evaluating how are reported. In an early study, Mahon Daniel<sup>3</sup>reviewed 203 drug trials published between 1956 1960 the<i>Canadian Medical...
Legislatively mandated programs for early intervention on behalf of handicapped infants often stipulate the inclusion physical therapy as a major component treatment cerebral palsy. To evaluate effects therapy, we randomly assigned 48 (12 to 19 months age) with mild severe spastic diplegia receive either 12 (Group A) or 6 preceded by infant stimulation B). The infant-stimulation program included motor, sensory, language, and cognitive activities increasing complexity. Masked outcome...
Background Improvement in patient outcome and reduced use of medical resources may result from using epidural anesthesia analgesia as compared with general intravenous opioids, although the relative importance intraoperative versus postoperative technique has not been studied. This prospective, double-masked, randomized clinical trial was designed to compare alternate combinations respect outcomes patients undergoing surgery abdominal aorta. Methods One hundred sixty-eight aorta were...
This study characterizes trends in the total number of clinical trials and proportion funded by National Institutes Health registered at ClinicalTrials.gov between 2006 2014.
An objective evaluation of patient performance status (PS) is difficult because patients spend the majority their time outside clinic, self-report to providers, and undergo dynamic changes throughout treatment experience. Real-time, activity data may allow for a more accurate assessment PS physical function, while reducing subjectivity bias associated with current assessments. Consenting advanced cancer wore wearble monitor three consecutive visits in prospective, single-cohort clinical...