A5084852641- Substance Abuse Treatment and Outcomes
- Neurotransmitter Receptor Influence on Behavior
- Child and Adolescent Psychosocial and Emotional Development
- Digital Mental Health Interventions
- Opioid Use Disorder Treatment
- Schizophrenia research and treatment
- Cannabis and Cannabinoid Research
- Psychotherapy Techniques and Applications
- Mental Health Research Topics
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Attention Deficit Hyperactivity Disorder
- Behavioral Health and Interventions
- Treatment of Major Depression
- Prenatal Substance Exposure Effects
- Health Policy Implementation Science
- Mental Health Treatment and Access
- Psychiatric care and mental health services
- Counseling Practices and Supervision
- Homelessness and Social Issues
- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- Gambling Behavior and Treatments
- Behavioral and Psychological Studies
- Smoking Behavior and Cessation
- Counseling, Therapy, and Family Dynamics
Yale University
2015-2024
National Institute on Drug Abuse
2002-2020
University School
2020
McLean Hospital
2016-2019
Harvard University
2004-2019
Connecticut Mental Health Center
1999-2019
VA Connecticut Research and Education Foundation
2019
Temple University
2019
VA Connecticut Healthcare System
2007-2018
Mental Illness Research, Education and Clinical Centers
2012-2016
The progressively rigorous methodological requirements of conducting clinical trials behavioral treatments has placed a large burden on individual investigators, as treatment manuals, methods evaluating quality and fidelity, persuasive evidence the treatment's promise are now virtual receiving support for trial new or adapted treatment. A Stage Model Behavioral Therapies research, by articulating progressive stages development evaluation treatments, recognizes scientific merit need initial...
We present a vision of clinical science, based on conceptual framework intervention development endorsed by the Delaware Project. This is grounded in an updated stage model that incorporates basic science questions mechanisms into every research. The presented intended to unify various aspects toward common goal developing maximally potent and implementable interventions, while unveiling new avenues which applied goals are equally high importance. Training this integrated, translational may...
There has been little research on the effectiveness of different training strategies or impact exposure to treatment manuals alone clinicians' ability effectively implement empirically supported therapies. Seventy-eight community-based clinicians were assigned 1 3 conditions: review a cognitive-behavioral therapy (CBT) manual only, plus access CBT Web site, didactic seminar followed by supervised casework. The primary outcome measure was demonstrate key interventions, as assessed independent...
<h3>Background</h3> Neuroimaging studies suggest that auditory hallucinations (AHs) of speech arise, at least in part, from activation brain areas underlying perception. One-hertz repetitive transcranial magnetic stimulation (rTMS) produces sustained reductions cortical activation. Recent results 4-day administration 1-Hz rTMS to left temporoparietal cortex were superior those sham reducing AHs. We sought determine if a more extended trial could significantly reduce AHs resistant...
In a meta-analysis, we examined factors that could account for the differences in therapist efficacy evidenced psychotherapy outcome studies. The investigated were: (1) use of treatment manual, (2) average level experience, (3) length treatment, and (4) type (cognitive/behavioral versus psychodynamic). Data were obtained from fifteen studies produced 27 separate groups. For each group, amount variance due to between therapists was calculated served as dependent variable meta-analysis. Each...
<h3>Context</h3> Disulfiram has emerged as a promising treatment for cocaine dependence, but it not yet been evaluated in general populations of users. <h3>Objectives</h3> To compare the effectiveness disulfiram therapy with that placebo condition reducing use and to 2 active behavioral therapies—cognitive behavior (CBT) interpersonal psychotherapy (IPT)—in use. <h3>Design</h3> Randomized, placebo-controlled, double-masked (for medication condition), factorial (2 × 2) trial 4 conditions:...
Neither the durability of brief ambulatory treatments for cocaine dependence nor relative ability psychotherapy vs pharmacotherapy to effect lasting change has been evaluated in well-controlled randomized trials.We conducted a 1-year naturalistic follow-up 121 abusers who underwent (cognitive-behavioral relapse prevention or clinical management) and (desipramine hydrochloride placebo) 2 x design. Subjects were interviewed 1, 3, 6, 12 months after termination 12-week course outpatient...
Objectives: This study evaluated the efficacy of a computer-based version cognitive-behavioral therapy (CBT) for substance dependence. Method: was randomized clinical trial in which 77 individuals seeking treatment dependence at an outpatient community setting were randomly assigned to standard or with biweekly access training CBT (CBT4CBT) skills. Results: Treatment retention and data availability comparable across conditions. Participants CBT4CBT condition submitted significantly more...
Stress is important in substance use disorders (SUDs). Mindfulness training (MT) has shown promise for stress-related maladies. No studies have compared MT to empirically validated treatments SUDs. The goals of this study were assess cognitive behavioral therapy (CBT) and treatment acceptability, specificity CBT targeting stress reactivity. Thirty-six individuals with alcohol and/or cocaine randomly assigned receive group or an outpatient setting. Drug was assessed weekly. After treatment,...
Abstract Aims To compare long‐term outcomes among participants randomized to buprenorphine or methadone. Design, Setting and Participants Follow‐up was conducted in 2011–14 of 1080 opioid‐dependent entering seven opioid treatment programs the United States between 2006 2009 (within each program) receive open‐label buprenorphine/naloxone methadone for up 24 weeks; 795 completed in‐person interviews (~74% follow‐up interview rate) covering on average 4.5 years. Measurements Outcomes were...
The authors sought to identify a brain-based predictor of cocaine abstinence by using connectome-based predictive modeling (CPM), recently developed machine learning approach. CPM is tool and method identifying networks that underlie specific behaviors ("neural fingerprints").Fifty-three individuals participated in neuroimaging protocols at the start treatment for use disorder, again end 12 weeks treatment. with leave-one-out cross-validation was conducted pretreatment predicted (percent...
To evaluate disulfiram and three forms of manual guided psychotherapy for individuals with cocaine dependence concurrent alcohol abuse or dependence.Randomized controlled trial.Urban substance treatment center.One hundred twenty-two cocaine/alcohol abusers (27% female; 61% African-American Hispanic).One five treatments delivered over 12 weeks: cognitive behavioral (CBT) plus disulfiram; Twelve Step facilitation (TSF) clinical management (CM) CBT no medication; TSF medication.Duration...
At present, there is no consensus regarding effective treatment for cocaine abuse or the most productive roles two major forms of treatment, pharmacotherapy and psychotherapy. We conducted first randomized clinical trial evaluating psychotherapy pharmacotherapy, alone in combination, as ambulatory abusers.One hundred thirty-nine subjects were assigned to one four conditions offered over a 12-week abstinence initiation trial: relapse prevention plus desipramine hydrochloride, management...