A5051746028- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- SARS-CoV-2 and COVID-19 Research
- Veterinary Orthopedics and Neurology
- Phosphodiesterase function and regulation
- Metabolism and Genetic Disorders
- Respiratory Support and Mechanisms
- Cardiac Fibrosis and Remodeling
- Cannabis and Cannabinoid Research
- HIV-related health complications and treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Protein Kinase Regulation and GTPase Signaling
- Alcohol Consumption and Health Effects
- Spinal Cord Injury Research
- Signaling Pathways in Disease
- Pluripotent Stem Cells Research
- Spinal Dysraphism and Malformations
- Cardiac electrophysiology and arrhythmias
- Nuclear Receptors and Signaling
- Folate and B Vitamins Research
- Cardiovascular Function and Risk Factors
- HIV/AIDS Research and Interventions
- COVID-19 and Mental Health
Boston Medical Center
2021-2023
Boston University
2020-2023
Molecular Medicine Research Institute
2021
Tufts Medical Center
2017-2018
University of Glasgow
2015
Myocardial hypertrophy is an independent risk factor for heart failure (HF), yet the mechanisms underlying pathological cardiomyocyte growth are incompletely understood. The c-Jun NH 2 -terminal kinase (JNK) signaling cascade modulates cardiac hypertrophic remodeling, but upstream factors regulating myocardial JNK activity remain unclear. In this study, we sought to identify JNK-activating molecules as novel regulators of remodeling in HF. We investigated mixed lineage kinase-3 (MLK3), a...
The nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic guanosine monophosphate (cGMP) signalling pathway plays a fundamental role in modulating diverse physiological processes including blood flow, fibrosis, inflammation, and metabolism.sGC stimulators are small-molecule, heme-dependent agonists of sGC that synergize with enhance endogenous NO signaling.As such, may provide therapeutic benefits both diseases associated impaired signaling where stimulation this will restore functional...
An 8 wk old male Yorkshire terrier was presented with a 2 history of recurrent hypoglycemia, lethargy, and seizures. Investigations revealed marked increase in blood ammonia, low serum cobalamin, increased levels urinary methylmalonic acid (MMA) excretion. No liver vascular abnormality detected. The patient diagnosed aciduria due to cobalamin malabsorption. responded well parenteral administration, the MMA normalized rapidly following instigation treatment. Due suspected hereditary nature...
A 10-year-old cat presented 5 days after a traumatic event with acute recumbency followed by some clinical improvement. The neuroanatomical localisation was the C1-C5 spinal cord segments. Initial survey radiographs, including lateral flexed views, showed no convincing abnormalities. Magnetic resonance imaging (MRI) revealed marked focal intramedullary lesion at level of dens and suspected oedema extending over C2-C3 vertebrae, suggesting early syrinx formation. made an initial excellent...
cGMP-dependent protein kinase 1α (PKG1α) promotes left ventricle (LV) compensation after pressure overload. PKG1-activating drugs improve heart failure (HF) outcomes but are limited by vasodilation-induced hypotension. Signaling molecules that mediate PKG1α cardiac therapeutic effects do not promote PKG1α-induced hypotension could therefore represent improved targets. We investigated roles of mixed lineage 3 (MLK3) in mediating on LV function overload and regulating BP. In a transaortic...
Objectives: People with substance use disorders (SUD) are suggested to have higher risk of hospitalization, intubation, or death from coronavirus disease 2019 (COVID-19), although data mixed. Little is known about other COVID-19-related complications in this group. We compared morbidity and mortality among individuals without SUD who were admitted an urban safety net hospital COVID-19 early the pandemic, contemporaneous published studies on subject. Methods: performed a retrospective study...
Early identification of patients at risk for severe coronavirus disease 2019 (COVID-19) is crucial appropriate triage and determination need closer monitoring. Few studies have examined laboratory trends in COVID-19 infection sought to quantify the degree which values affect mortality. We conducted a retrospective cohort (n = 407) study hospitalized with early course pandemic, from March 16th April 8th, 2020 compared baseline repeat testing 72 hours into admission. The primary outcome was...
Delayed CD4 recovery after initiating antiretroviral therapy (ART) is a novel potential mechanism by which alcohol consumption leads to increased morbidity and mortality in people with HIV. We hypothesized that at ART initiation associated slower recovery.
Background: The impact of interleukin-6 receptor inhibitors (IL6ri) on Coronavirus disease 2019 (Covid-19) outcomes remains uncertain. Methods: Patients with severe and critical Covid-19 were given an IL6ri (sarilumab or tocilizumab) based pragmatic iteratively reviewed guidelines at a safety net hospital diverse population. initially reserved for critically ill patients, but after review, treatment was liberalized to patients requiring >4 liters/minute oxygen having alveolar-arterial...
Obesity increases morbidity and mortality from Coronavirus disease 2019 (COVID-19). This study characterized inpatient complications among patients with obesity COVID-19-including myocardial infarction, renal failure requiring dialysis, stroke, secondary bacterial infection, venous thromboembolism-and identified factors associated developing at least one complication a safety-net hospital diverse cohort.
Abstract Background Early data suggest that people with substance use disorder (SUD) who develop coronavirus disease 2019 (COVID-19) have increased intubation and mortality rates when compared to those without SUD. Information on other COVID-19-related complications in this population is limited. We evaluated COVID-19 outcomes patients Methods created a retrospective cohort of admitted an urban safety net hospital from 3/16/2020 4/8/2020. Inclusion criteria were admission...