A5045833909- Head and Neck Cancer Studies
- Tracheal and airway disorders
- Cancer Diagnosis and Treatment
- Cleft Lip and Palate Research
- Cancer Research and Treatments
- Endoplasmic Reticulum Stress and Disease
- Genetic factors in colorectal cancer
- Cervical Cancer and HPV Research
- Craniofacial Disorders and Treatments
- Phosphodiesterase function and regulation
- Voice and Speech Disorders
- Cancer, Hypoxia, and Metabolism
- Pharmacological Effects of Natural Compounds
- Plasma Applications and Diagnostics
- Multiple and Secondary Primary Cancers
- Glycosylation and Glycoproteins Research
- Digital Imaging in Medicine
- Interpreting and Communication in Healthcare
- Sinusitis and nasal conditions
- Galectins and Cancer Biology
- Cancer Immunotherapy and Biomarkers
- Thyroid and Parathyroid Surgery
- Metastasis and carcinoma case studies
- Hedgehog Signaling Pathway Studies
- Salivary Gland Tumors Diagnosis and Treatment
Mayo Clinic
2022-2024
Mayo Clinic in Arizona
2022-2024
University of Minnesota Rochester
2022-2023
WinnMed
2022
Thomas Jefferson University
2014-2020
Io Therapeutics (United States)
2019
Immunogenic cell death is characterized by the emission of danger signals that facilitate activation an adaptive immune response against dead-cell antigens. In case cancer therapy, tumor cells undergoing immunogenic promote cancer-specific immunity. Identification, characterization, and optimization stimuli induce has tremendous potential to improve outcomes therapy. this study, we show non-thermal, atmospheric pressure plasma can be operated in animal model colorectal cancer.
Abstract Background/Objectives: The uroguanylin-GUCY2C gut–brain axis has emerged as one component regulating feeding, energy homeostasis, body mass and metabolism. Here, we explore a role for this in mechanisms underlying diet-induced obesity (DIO). Subjects/Methods: Intestinal uroguanylin expression secretion, hypothalamic GUCY2C anorexigenic signaling, were quantified mice on high-calorie diets 14 weeks. of endoplasmic reticulum (ER) stress suppressing DIO was explored using tunicamycin,...
PD-1 blockade represents a promising treatment in patients with head and neck squamous cell carcinoma (HNSCC). We analyzed results of neoadjuvant randomized window-of-opportunity trial nivolumab plus/minus tadalafil to investigate whether immunotherapy-mediated effects vary by site involvement (primary tumor, lymph nodes) determine how radiographic tumor shrinkage correlates pathologic effect. Forty-four enrolled NCT03238365 were treated 240 mg intravenously on days 1 15 or without oral...
Enterotoxigenic Escherichia coli (ETEC) causes ∼20% of the acute infectious diarrhea (AID) episodes worldwide, often by producing heat-stable enterotoxins (STs), which are peptides structurally homologous to paracrine hormones intestinal guanylate cyclase C (GUCY2C) receptor. While molecular mechanisms mediating ST-induced secretion have been defined, advancements in therapeutics hampered for decades paucity disease models that integrate and functional endpoints amenable high-throughput...
// Glen P. Marszalowicz 1 , Adam E. Snook 2 Michael S. Magee Dante Merlino Lisa D. Berman-Booty 3 and Scott A. Waldman School of Biomedical Engineering, Science, Health Systems, Drexel University, Philadelphia, PA, USA Department Pharmacology Experimental Therapeutics, Thomas Jefferson Cancer Biology, Correspondence: Waldman, email: Keywords : GUCY2C, immunotoxin, therapeutic targeting, metastatic colorectal cancer Received August 14, 2014 Accepted September 07, Published 08, Abstract The...
The nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic guanosine monophosphate (cGMP) signalling pathway plays a fundamental role in modulating diverse physiological processes including blood flow, fibrosis, inflammation, and metabolism.sGC stimulators are small-molecule, heme-dependent agonists of sGC that synergize with enhance endogenous NO signaling.As such, may provide therapeutic benefits both diseases associated impaired signaling where stimulation this will restore functional...
Objectives To measure baseline human papillomavirus (HPV) vaccination rates among tertiary and community‐based Otolaryngology – Head Neck Surgery (Oto‐HNS) clinic patients to determine risk factors for under‐vaccination. Methods Retrospective chart review of aged 9 26 years presenting an Oto‐HNS from 2017 2019. Patients were considered complete HPV if they received two doses vaccine with the first dose before age 15 or three otherwise. Results 8,532 unique met criteria. At index visit, 3,110...
Objective To describe the rare process of osteolytic labyrinthitis, previously referred to as labyrinthine sequestrum, which involves progressive obliteration bony and membranous labyrinth with eventual supplantation soft tissue and, in some cases, sequestrum. Patients Three patients diverse presentations labyrinthitis from two tertiary care academic medical centers. Intervention(s) Case series report analyzing relevant clinical, radiologic, pathologic, surgical data on our comparing these...
Objective The purpose of this study was to evaluate the performance advanced large language models from OpenAI (GPT‐3.5 and GPT‐4), Google (PaLM2 MedPaLM), an open source model Meta (Llama3:70b) in answering clinical test multiple choice questions field otolaryngology—head neck surgery. Methods A dataset 4566 otolaryngology used; each provided a standardized prompt followed by question. One hundred that were answered incorrectly all further interrogated gain insight into causes incorrect...
Abstract Disclosure: K.N. Rachmasari: None. A. Osman: D. Toro Tobon: S.B. Lund: D.J. Merlino: A.R. Hsu: M.M. Ryder: Background: In low-risk papillary thyroid cancer (PTC), radioactive iodine (RAI) remnant ablation has shown no impact on disease recurrence rates, which are overall low. The role of adjuvant RAI in intermediate risk (i.e. T3, N1) remains unproven with randomized clinical trials to objectively assess efficacy. Thus, our institution, its use is highly heterogenous. We...