A5014336941- Cutaneous lymphoproliferative disorders research
- Nail Diseases and Treatments
- Autoimmune Bullous Skin Diseases
- Fungal Infections and Studies
- Lymphoma Diagnosis and Treatment
- Cancer and Skin Lesions
- Genetic and rare skin diseases.
- Hedgehog Signaling Pathway Studies
- Chronic Lymphocytic Leukemia Research
- Nonmelanoma Skin Cancer Studies
- Cutaneous Melanoma Detection and Management
- Eosinophilic Disorders and Syndromes
- Drug-Induced Adverse Reactions
- melanin and skin pigmentation
- RNA regulation and disease
- CNS Lymphoma Diagnosis and Treatment
- Skin and Cellular Biology Research
- Melanoma and MAPK Pathways
- T-cell and Retrovirus Studies
- Sympathectomy and Hyperhidrosis Treatments
- Chemotherapy-related skin toxicity
- Acute Myeloid Leukemia Research
- Dermatological and Skeletal Disorders
- Connexins and lens biology
- Dermatologic Treatments and Research
Dermatology Specialists
2021-2022
Gorgias Press (United States)
2021
Thomas Jefferson University
2011-2020
University of Alabama at Birmingham
2020
RELX Group (United States)
2020
Advanced Dermatology
2016-2019
Thomas Jefferson University Hospital
2012-2019
Jefferson University Hospitals
2019
University of Tennessee Health Science Center
2016
Jefferson Institute
2005-2011
Immunogenic cell death is characterized by the emission of danger signals that facilitate activation an adaptive immune response against dead-cell antigens. In case cancer therapy, tumor cells undergoing immunogenic promote cancer-specific immunity. Identification, characterization, and optimization stimuli induce has tremendous potential to improve outcomes therapy. this study, we show non-thermal, atmospheric pressure plasma can be operated in animal model colorectal cancer.
Early-onset squamous cell carcinoma in recessive dystrophic epidermolysis bullosa patients is characterized by APOBEC mutagenesis.
Cutaneous involvement by an eosinophil‐rich process (eosinophilic dermatosis) may be encountered in the setting of various hematologic malignancies, including mantle cell lymphoma, acute monocytic leukemia, lymphoblastic large myelofibrosis and chronic lymphocytic leukemia (CLL). Of eosinophilic dermatosis has been most frequently described association with CLL. Published previously as insect bite‐like reaction myeloproliferative disease, this rare dermatitis presents a pruritic, papular...
Aesthetically, striae distensae (SD) are a source of great concern. No treatment modality is currently considered the gold standard. However, studies nonablative fractionated lasers (NAFLs) have been promising.To evaluate and compare clinical histopathologic efficacy safety 1540-nm NAFL 1410-nm for SD.Nine patients with abdominal were treated 6 sessions-half abdomen was whereas other half NAFL. Photographs taken at baseline 3-month follow-up visit, when subjects given questionnaire. Two...
Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma within general population. Low dose total skin electron beam therapy (TSEBT) and topical nitrogen mustard (Valchlor) are two treatment modalities that have been proven to be efficacious in MF. While each studied independently various clinical trials, use Valchlor as maintenance after completion low TSEBT rarely implemented due lack evidence literature. The Jefferson multidisciplinary clinic has found great success...
Adult‐onset Still disease ( AOSD ) is a rare autoinflammatory syndrome characterized by recurring fevers, arthralgia, and consistent laboratory abnormalities that include leukocytosis hyperferritinemia. Skin findings accompany the in nearly 90% of cases. Early reports described evanescent, pruritic, salmon‐pink or urticarial lesions, referred to as typical eruption . Histopathologic consist superficial perivascular dermatitis with varying number interstitial neutrophils. Later more...
Aberrant activation of Hedgehog (Hh) signaling is causative BCCs and has been associated with a fraction SCCs. Desmoglein 2 (Dsg2) an adhesion protein that upregulated in many cancers overexpression Dsg2 the epidermis renders mice more susceptible to squamous-derived neoplasia. Here we examined potential crosstalk between Hh skin tumorigenesis. Our findings show modulates Gli1 expression, vitro vivo. Ectopic expression on Ptc1(+/lacZ) background enhanced epidermal proliferation...
Mycosis fungoides (MF), the most common form of cutaneous T-cell lymphoma, remains a challenge for clinicians to stage and manage. Classically, MF is determined through histopathologic evidence neoplastic infiltrate within epidermis. In certain patients, however, extends into hair follicles sweat glands. The objective this study determine utility expanding analysis histopathology reports include reporting folliculotropism syringotropism.This prospective, observational conducted in single...
Scleromyxedema is a systemic disease characterized by lichenoid papules, nodules, and plaques on the skin often diffuse induration resembling cutaneous involvement of sclerosis. The affects musculoskeletal, pulmonary, cardiovascular, gastrointestinal, central nervous systems, disorder commonly associated with paraproteinemia. Involvement kidney rare not considered feature disease. Here, we describe an unusual case scleromyxedema complicated development scleroderma renal crisis-like acute...
Syringocystadenoma papilliferum (SCAP) is an uncommon cutaneous adnexal proliferation. There have been several reports describing collision lesions of SCAP and verruca, although little known about the frequency this association. Molecular testing has revealed BRAFV600E mutation in a large proportion cases, its expression pattern not previously evaluated.In retrospective analysis, we explored potential histopathological association between verruca SCAP. We also evaluated mutation-specific...
Balloon cell melanoma is a rare subtype of that underrecognized clinically and challenging to diagnose on histologic studies.To further characterize the clinical, dermoscopic, histopathologic features balloon melanomas their correlation gene expression.Case series 2 patients with whose medical records were retrieved from database Thomas Jefferson University Dermatopathology Center in Philadelphia, Pennsylvania. Both cases had been referred institution's dermatopathology laboratory provided...
Acquired brachial cutaneous dyschromatosis is an acquired pigmentary disorder that has been described in only 20 patients but likely affects many more. This case of a man with unique as most reports are women. We report the 60-year-old male who presents asymptomatic eruption characterized by hyperpigmented and telangiectatic macules coalescing into patches on bilateral extensor aspects forearms which consistent clinically histopathologically dyschromatosis. Given its presence clinical...