A5013091960- Cutaneous Melanoma Detection and Management
- Cutaneous lymphoproliferative disorders research
- Cancer and Skin Lesions
- Autoimmune Bullous Skin Diseases
- Nail Diseases and Treatments
- Genetic and rare skin diseases.
- Nonmelanoma Skin Cancer Studies
- Eosinophilic Disorders and Syndromes
- Tumors and Oncological Cases
- Infectious Diseases and Mycology
- Autoimmune and Inflammatory Disorders
- Skin and Cellular Biology Research
- Dermatological diseases and infestations
- AI in cancer detection
- Melanoma and MAPK Pathways
- Vascular Tumors and Angiosarcomas
- Lymphoma Diagnosis and Treatment
- Medicine and Dermatology Studies History
- Hedgehog Signaling Pathway Studies
- melanin and skin pigmentation
- Genital Health and Disease
- Histiocytic Disorders and Treatments
- Cell Image Analysis Techniques
- Fungal Infections and Studies
- Drug-Induced Adverse Reactions
Thomas Jefferson University
2015-2024
Thomas Jefferson University Hospital
2014-2024
Jefferson University Hospitals
2020-2023
Philadelphia University
2005-2023
Temple University Hospital
2023
Temple University
2021-2023
Commonwealth Medical College
2022
Advanced Dermatology
2012-2016
In-Q-Tel
2013
Chestnut Hill College
2013
The mechanisms underlying adaptive resistance of melanoma to targeted therapies remain unclear. By combining ChIP sequencing with microarray-based gene profiling, we determined that ERBB3 is upregulated by FOXD3, a transcription factor promotes RAF inhibitors in melanoma. Enhanced signaling promoted pathway cultured cell lines and mouse xenograft models. was dependent on ERBB2; targeting ERBB2 lapatinib combination the inhibitor PLX4720 reduced tumor burden extended latency regrowth vivo...
Objective. A prospective observational study of mycophenolate mofetil (MMF) treatment in patients with diffuse progressive cutaneous systemic sclerosis (SSc) recent onset. Methods. Twenty-five previously untreated consecutive recent-onset (< 24 mo) SSc received MMF as the only disease-modifying therapy. Modified Rodnan skin score (mRSS) and affected body surface area (BSA) were compared from initiation to end. Pulmonary function tests performed at same institution before therapy end...
Cutaneous involvement by an eosinophil‐rich process (eosinophilic dermatosis) may be encountered in the setting of various hematologic malignancies, including mantle cell lymphoma, acute monocytic leukemia, lymphoblastic large myelofibrosis and chronic lymphocytic leukemia (CLL). Of eosinophilic dermatosis has been most frequently described association with CLL. Published previously as insect bite‐like reaction myeloproliferative disease, this rare dermatitis presents a pruritic, papular...
Standard of care diagnostic procedure for suspected skin cancer is microscopic examination hematoxylin \& eosin stained tissue by a pathologist. Areas high inter-pathologist discordance and rising biopsy rates necessitate higher efficiency reproducibility. We present validate deep learning system which classifies digitized dermatopathology slides into 4 categories. The developed using 5,070 images from single lab, tested on an uncurated set 13,537 3 test labs, whole slide scanners...
A 68-year-old woman with a history of seizures on cenobamate presented an itchy rash all over her body. The started about one month prior to presentation the dermatology clinic. was initially treated topical triamcinolone improvement at one-month follow-up. However, four months later flared and there concern that cause. Biopsy performed showing vacuolar interface dermatitis atrophy, suggestive subacute lupus erythematosus. Blood work revealed positive antinuclear antibody,...
The lack of highly specific clinical and histopathological criteria has contributed to the delay in diagnosis subungual melanoma situ its early stages.Eighteen cases situ, largest series reported date, were analyzed characterize findings stages along with five nail matrix nevus lentigo serving as histologic control.Clinically, longitudinal melanonychia was present all 18 consisting irregular dark brown black streaks within a background (11 cases) or without Hutchinson's sign....
Leukemia cutis (LC) and eosinophilic dermatosis of hematologic malignancy (EDHM) are rare cutaneous manifestations malignancies. Various therapeutic options have been reported, with largely underwhelming responses. We present a patient chronic lymphocytic leukemia (CLL) concomitant LC EDHM who was treated dupilumab.
Although melanoma occurs more rarely than several other skin cancers, patients' long term survival rate is extremely low if the diagnosis missed. Diagnosis complicated by a high discordance among pathologists when distinguishing between and benign melanocytic lesions. A tool that allows pathology labs to sort prioritize cases in their workflow could improve turnaround time prioritizing challenging routing them directly appropriate sub-specialist. We present deep learning system (PDLS)...