A5000858768- Nail Diseases and Treatments
- Cutaneous lymphoproliferative disorders research
- Glaucoma and retinal disorders
- melanin and skin pigmentation
- Catalytic C–H Functionalization Methods
- Lymphoma Diagnosis and Treatment
- Chromatin Remodeling and Cancer
- Cancer and Skin Lesions
- Dermatology and Skin Diseases
- Protein Degradation and Inhibitors
- Dermatologic Treatments and Research
- Retinal Imaging and Analysis
- Hair Growth and Disorders
- Corneal surgery and disorders
- Synthesis and Catalytic Reactions
- Seaweed-derived Bioactive Compounds
- Food Quality and Safety Studies
- Retinal Diseases and Treatments
- Health and Wellbeing Research
- Skin Protection and Aging
- Chemotherapy-related skin toxicity
- Pharmacological Effects of Natural Compounds
- Cutaneous Melanoma Detection and Management
- Genomics and Chromatin Dynamics
- Infectious Diseases and Mycology
Daejeon University
2022-2025
Samsung (South Korea)
2025
Sungkyunkwan University
2015-2024
Korea University
2011-2024
Samsung Medical Center
2015-2024
University of Central Florida
2024
Korea Institute of Radiological and Medical Sciences
2021-2024
Bucheon University
2024
Soonchunhyang University
2024
Dankook University
2024
We propose a class of kernel stick-breaking processes for uncountable collections dependent random probability measures. The process is constructed by first introducing an infinite sequence locations. Independent measures and beta-distributed weights are assigned to each location. Predictor-dependent then mixing over the locations, with probabilities expressed as multiplied beta weights. Some theoretical properties described, including covariate-dependent prediction rule. A retrospective...
The linear or branched allyl moieties on aromatic rings are well-known as ubiquitous structural motifs found in a range of natural products and medicinally relevant molecules. They also represent an important class organic intermediates for the transformation olefin group into many useful functional groups. Established methods installation allylic groups rely primarily nucleophilic substitution transmetalation aryl metal complexes to electrophiles, Lewis acid-mediated Friedel–Crafts...
Abstract DOT1L has emerged as an anticancer target for MLL-associated leukaemias; however, its functional role in solid tumours is largely unknown. Here we identify that cooperates with c-Myc and p300 acetyltransferase to epigenetically activate epithelial–mesenchymal transition (EMT) regulators breast cancer progression. recognizes SNAIL , ZEB1 ZEB2 promoters via interacting the c-Myc-p300 complex facilitates lysine-79 methylation acetylation towards histone H3, leading dissociation of...
BACKGROUND The purpose of the current study was to examine effect an oncologist's exercise recommendation with and without motivation package on amount participation quality life (QOL) in survivors breast colorectal cancer. METHODS A total 162 early‐stage cancer who completed primary adjuvant treatments were recruited for study. Participants randomly assigned into 1 3 groups: 1) control (59 patients); 2) those receiving (53 3) (50 patients). At baseline after 4 weeks, level QOL assessed....
Background: Staphylococcus aureus (SA) has peculiar abilities to colonize the skin in atopic dermatitis (AD) patients.Objective: We sought determine colonization rates of SA acute and chronic lesions AD patients, find any difference according age influences total immunoglobulin E (IgE) eosinophil counts SA.Methods: evaluated IgE level counts, cultured from 687 patients (131 556 lesions) 247 control urticaria (July 2009 November 2010; Samsung Medical Center Dermatology Clinic, Seoul,...
The rhodium(III)-catalyzed cross-coupling reaction of 8-methylquinolines and maleimides is described. In contrast to the C(sp2)–H functionalization, a first catalytic functionalization sp3 C–H bonds with reported. This protocol provides facile access various succinimide scaffolds on via direct cleavage approach.
The weakly coordinating ketone group directed C–H functionalizations of chromones, 1,4-naphthoquinones, and xanthones with various maleimides under rhodium(III) catalysis are described. These protocols efficiently provide a range succinimide-containing naphthoquinones, excellent site selectivity functional compatibility. All synthetic compounds were screened for in vitro anticancer activity against human breast adenocarcinoma cell lines (MCF-7). In particular, 7aa 7ca naphthoquinone scaffold...
In this study, local electric field distributions generated by transcranial direct current stimulation (tDCS) with an extracephalic reference electrode were evaluated to address tDCS safety issues. To aim, we a numerical model of adult male human upper body and applied the 3D finite element method conduction analysis. our simulations, active was placed over left primary motor cortex (M1) at six different locations: right temporal lobe, on supraorbital region, deltoid, under chin, buccinator...
The ruthenium-catalyzed oxidative allylation of aromatic and α,β-unsaturated carboxamides with allylic carbonates is described. These transformations proceed readily complete linear γ-selectivity substituted carbonates.
Abstract Background Although chemotherapy-induced alopecia (CIA) is considered temporary, some patients report persistent several years after chemotherapy. There is, however, a paucity of long-term prospective data on the incidence and impact permanent CIA (PCIA). The objective our study was to estimate PCIA in cohort with breast cancer whose hair volume density were measured prior chemotherapy who followed for 3 Materials Methods Prospective consecutive ≥18 age postoperative diagnosis stage...
Purpose The purpose of this study is to investigate the effect factors associated with e‐learning, particularly computer attitudes and usability, on transfer training in workplace e‐learning courses. Design/methodology/approach This relied quantitative data obtained from four online survey questionnaires. sample was 47 learners who took either one soft‐skill course or hard‐skill a selected company their supervisors. Findings results demonstrated that learners' impact perception usability...
A ketone-assisted ruthenium-catalyzed selective amination of xanthones and chromones C–H bonds with sulfonyl azides is described. The reactions proceed efficiently a broad range substrates excellent functional group compatibility. This protocol provides direct access to 1-aminoxanthones, 5-aminochromones, 5-aminoflavonoid derivatives known exhibit potent anticancer activity.
A rhodium(III)-catalyzed oxidative olefination of 1,2-disubstituted arylhydrazines with alkenes via sp2 C–H bond activation followed by an intramolecular aza-Michael reaction is described. This strategy allows the direct and efficient construction highly substituted 2,3-dihydro-1H-indazole scaffolds.
The differential diagnosis of psoriasis and seborrheic dermatitis can be difficult when both conditions are localized to the scalp without involvement other skin sites.We aimed evaluate histopathological differences between on identify favorable criteria for their diagnosis.We evaluated 15 cases 20 that had been clinicopathologically diagnosed. Skin biopsy sections stained with H&E were examined. Additional immunohistochemistry was performed, including Ki-67, keratin 10, caspase-5, GLUT-1.On...
The rhodium-catalyzed oxidative alkenylation of<italic>N</italic>-benzyltriflamides with olefins followed by an intramolecular cyclization<italic>via</italic>C–H bond activation is described.
The purpose of the present study was to examine 1) characteristics and attitudes oncologists toward exercise recommending their patients, 2) association among oncologists' own physical activity levels, recommendations, exercise.A total 167 participated in this survey (41 surgeons, 78 medical oncologists, 25 radiation 21 others). Most included treat more than one type cancer, including colorectal, gastric, breast, lung, liver cancer. To analyze data, one-way ANOVA, t-test were used. All data...
Postinflammatory hyperpigmentation (PIH) commonly occurs, but the histopathological features are not well characterized.A total of 21 PIH patients' medical charts were reviewed. Punch biopsies from lesional and perilesional normal skin performed. Sections stained with hematoxylin-eosin, Fontana-Masson, NKI/beteb, microphthalmia-associated transcription factor (MITF), CD68, c-kit, XIIIa, MMP-2 MMP-9.Fontana-Masson-stained sections suggested two obvious groups: epidermal (13 cases) dermal (8...
The aim of this study was to compare the peripapillary vessel density between eyes with pseudoexfoliation glaucoma (PXG) and primary open-angle (POAG).Peripapillary in radial capillaries assessed using optical coherence tomography angiography, compared patients PXG those POAG, matched for age mean deviation (MD) standard automated perimetry. measured optic disc margin 750 μm from margin.In total, 39 were POAG. Mean untreated intraocular pressure higher group than POAG (21.4±6.7 vs. 14.9±2.9...
In this study, we investigated the synergistic effect of co-administration osimertinib and HAD-B1 using gefitinib-resistant non-small cell lung cancer cells, HCC827-GR. is composed 4 natural drugs, Panax Notoginseng Radix, ginseng C. A. Meyer, Cordyceps militaris, Boswellia carterii Birdwood, has been reported to have therapeutic effects on patients with advanced in several studies. Resistance gefitinib HCC827 cells was acquired through MET activity. Co-treatment reduced viability HCC827-GR...