A5101839304- Stroke Rehabilitation and Recovery
- Transcranial Magnetic Stimulation Studies
- Acute Ischemic Stroke Management
- Muscle activation and electromyography studies
- Cerebral Palsy and Movement Disorders
- Advanced Neuroimaging Techniques and Applications
- Botulinum Toxin and Related Neurological Disorders
- Spinal Cord Injury Research
- Balance, Gait, and Falls Prevention
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Dementia and Cognitive Impairment Research
- Neurological Disorders and Treatments
- Neurological disorders and treatments
- Dysphagia Assessment and Management
- Prosthetics and Rehabilitation Robotics
- Vestibular and auditory disorders
- Parkinson's Disease Mechanisms and Treatments
- Musculoskeletal pain and rehabilitation
- Shoulder Injury and Treatment
- Motor Control and Adaptation
- Voice and Speech Disorders
- Nerve injury and regeneration
- Neurological Disease Mechanisms and Treatments
- Advanced MRI Techniques and Applications
Samsung Medical Center
2016-2025
Sungkyunkwan University
2016-2025
Samsung (South Korea)
2014-2025
Samsung (India)
2023
Regenerative Medicine Institute
2021
Ulsan College
2021
Keimyung University Dongsan Medical Center
2021
University of Ulsan
2021
Asan Medical Center
2021
Gyeongsang National University
2021
Functional MRI (fMRI) studies could provide crucial information on the neural mechanisms of motor recovery in patients with stroke. Resting-state fMRI is applicable to stroke who are not capable proper performance task. In this study, we explored correlates by investigating longitudinal changes resting-state functional connectivity ipsilesional primary cortex (M1).A observational study using repeated experiments was conducted 12 data were acquired 4 times over a period 6 months. Patients...
<h3>Objective</h3> To test whether autologous modified mesenchymal stem cells (MSCs) improve recovery in patients with chronic major stroke. <h3>Methods</h3> In this prospective, open-label, randomized controlled trial blinded outcome evaluation, severe middle cerebral artery territory infarct within 90 days of symptom onset were assigned, a 2:1 ratio, to receive preconditioned MSC injections (MSC group) or standard treatment alone (control group). The primary was the score on Rankin Scale...
Repetitive transcranial magnetic stimulation (rTMS) has been recognized as a promising intervention for treatment of stroke patients. However, most previous reports have described the short-term effects rTMS on motor performance. We conducted sham-controlled trial to evaluate long-term high-frequency recovery in subacute patients.Twenty-eight patients were randomly divided into two groups, and received either real or control rTMS. Both treatments accompanied by practice. A daily dose 1000...
. Robot-assisted gait training has the potential to improve cardiopulmonary fitness after stroke, even for patients who are in early stages of recovery and not independent ambulators. The authors compared effects robot-assisted conventional physical therapy on fitness.. A prospective single-blinded, randomized controlled study 37 receiving inpatient rehabilitation was performed within 1 month stroke onset. group (n = 20) received 40 minutes with Lokomat 60 each day, whereas control 17) 100...
The aims of this paper were to investigate the effectiveness a newly developed wearable hip assist robot, that uses an active algorithm improve gait function, muscle effort, and cardiopulmonary metabolic efficiency in elderly adults. Thirty adults (15 males/ 15 females) participated thispaper. experimental protocol consisted overground at comfortable speed under three different conditions: free without robot assistance, robot-assisted with zero torque (RAG-Z), full RAG. Under all conditions,...
Purpose: Freezing of gait (FOG) affects mobility and balance seriously.Few reports have investigated the effects repetitive transcranial magnetic stimulation (rTMS) on FOG in Parkinson's disease (PD).We efficacy high-frequency rTMS for treatment PD.Methods: Seventeen patients diagnosed with PD were recruited a randomized, double-blinded, cross-over study.We applied high frequency (90% resting motor threshold, 10 Hz, 1,000 pulses) over lower leg primary cortex dominant hemisphere (M1-LL) five...
Background and Purpose— The purpose of this study was to investigate the effects gait training with a newly developed wearable hip-assist robot on locomotor function efficiency in patients chronic stroke. Methods— Twenty-eight stroke hemiparesis were initially enrolled, 26 completed randomized controlled trial (14 experimental 12 control groups). group participated program over total 10 sessions, including 5 treadmill sessions over-ground while wearing robot, Gait Enhancing Motivating System...
Assessment of functional independence and residual disability is very important for measuring treatment outcome after stroke. The modified Rankin Scale (mRS) the Barthel Index (MBI) are commonly used scales to measure or dependence in activities daily living (ADL) stroke survivors. Lack consensus regarding MBI score categories has caused confusion interpreting outcomes. purpose this study was identify optimal corresponding scale grades categorization MBI. Korean versions (K-MBI) mRS were...
Stem cell-based therapy is a promising approach to repair brain damage after stroke. This study was conducted investigate changes in neuroimaging measures using stem patients with ischemic stroke.In this prospective, open-label, randomized controlled trial blinded outcome evaluation, severe middle cerebral artery territory infarct were assigned the autologous mesenchymal cell (MSC) treatment or control group. Of 54 who completed intervention, 31 for MSC and 13 groups included analysis. Motor...
Background and objectives Aneurysmal subarachnoid hemorrhage (aSAH) remains a significant global health concern, therefore, understanding their functional outcomes is essential. The aim of this study was to investigate the 1-year patients with aSAH. Methods We retrospectively analyzed data aSAH from Korean Stroke Cohort for Functioning Rehabilitation study, up post-onset. cohort were collected twice. 1st August 2012 through May 2015, 2nd January December in 2020, nine different hospitals....
In this study, local electric field distributions generated by transcranial direct current stimulation (tDCS) with an extracephalic reference electrode were evaluated to address tDCS safety issues. To aim, we a numerical model of adult male human upper body and applied the 3D finite element method conduction analysis. our simulations, active was placed over left primary motor cortex (M1) at six different locations: right temporal lobe, on supraorbital region, deltoid, under chin, buccinator...
Cerebrolysin is a neuropeptide preparation with neuroprotective and neurorestorative effects. Combining treatment standardized rehabilitation program may have potential synergistic effect in the subacute stage of stroke. This study aims to evaluate whether provides additional motor recovery on top therapy stroke patients moderate severe impairment.
A robotic exoskeleton device is an intelligent system designed to improve gait performance and quality of life for the wearer. Robotic technology has developed rapidly in recent years, several robot-assisted devices were enhance function activities daily living elderly adults patients with disorders. In this study, we investigated effects Gait-enhancing Mechatronic System (GEMS), a new wearable hip-assist by Samsung Electronics Co, Ltd., Korea, on foot pressure distribution adults. Thirty...
Background and Purpose— The theory of cognitive reserve (CR) was introduced to account for individual differences in the clinical manifestation neuropathology. This study investigated whether CR has a modulating effect on impairment recovery after stroke. Methods— is an interim analysis Korean Stroke Cohort Functioning Rehabilitation. A total 7459 patients with first-ever stroke were included analysis. Education, occupation, composite scores derived from those 2 variables used as proxies....
Mesenchymal stem cells (MSCs) secrete trophic factors and extracellular vesicles (EVs). However, the level role of EVs after MSC therapy in patients with stroke are unknown. We investigated whether circulating increased MSCs related to therapeutic benefits STARTING-2 trial (Stem Cell Application Researches Trials Neurology-2) participants.In this prospective randomized controlled trial, chronic major were assigned, a 2:1 ratio, receive autologous intravenous injection (MSC group, n=39) or...