A5056727306- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Connective tissue disorders research
- Cardiovascular Function and Risk Factors
- Aortic aneurysm repair treatments
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Stroke Rehabilitation and Recovery
- Congenital Heart Disease Studies
- Cardiomyopathy and Myosin Studies
- Cardiac Structural Anomalies and Repair
- Cerebrovascular and Carotid Artery Diseases
- Vasculitis and related conditions
- Cardiovascular Health and Disease Prevention
- Acute Ischemic Stroke Management
- Cardiovascular Disease and Adiposity
- Vascular Anomalies and Treatments
- Venous Thromboembolism Diagnosis and Management
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Issues in Pregnancy
- Japanese History and Culture
- Renal and Vascular Pathologies
- Peripheral Artery Disease Management
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Coronary Artery Anomalies
Sungkyunkwan University
2016-2025
Samsung Medical Center
2016-2025
Spanish Oncology Genitourinary Group
2024
Seoul National University Hospital
2023
Weatherford College
2022
Hanmi Pharmaceutical (South Korea)
2017
Samsung (South Korea)
2015
Imaging Center
2011-2015
Seoul National University
2010-2013
Samsung (United States)
2012
Cerebrolysin is a neuropeptide preparation with neuroprotective and neurorestorative effects. Combining treatment standardized rehabilitation program may have potential synergistic effect in the subacute stage of stroke. This study aims to evaluate whether provides additional motor recovery on top therapy stroke patients moderate severe impairment.
This phase 1 clinical trial tested the safety of intramuscular gene transfer by using naked plasmid DNA encoding for VEGF, and analyzed potential therapeutic benefits in patients with severe peripheral arterial disease (PAD). study was an open-labeled, dose- escalating, single-center on nine male debilitating PAD who had not responded to conventional therapy. Seven Buerger's two arteriosclerosis obliterans. Plasmid (pCK) containing human VEGF165 given eight injections around area need new...
Left ventricular non-compaction (LVNC) is an unclassified cardiomyopathy and there no consensus on the diagnosis of LVNC. The aims this study were to establish quantitative methods diagnose LVNC using cardiovascular magnetic resonance (CMR) suggest refined semi-quantitative This retrospective included 145 subjects with mild severe trabeculation left ventricle myocardium [24 patients isolated LVNC, 33 non-isolated 30 dilated (DCM) (DCMNC), 27 DCM, 31 healthy control trabeculation]. (LV)...
Abstract Background Marfan syndrome (MFS), caused by pathogenic variants of FBN1 (fibrillin‐1), is a systemic connective tissue disorder with variable phenotypes and treatment responsiveness depending on the variant. However, significant number individuals MFS remain genetically unexplained. In this study, we report novel intronic in two unrelated families MFS. Methods We evaluated subjects suspected from using Sanger sequencing or multiplex ligation‐dependent probe amplification and/or...
There are insufficient studies to determine whether sodium-glucose cotransporter type 2 inhibitors (SGLT2i) will help reduce early diabetic cardiomyopathy, especially in patients without documented cardiovascular disease. We performed a single center, prospective observation study. A total of 90 with diabetes established heart failure or atherosclerotic disease were enrolled. Echocardiography, cardiac enzyme, and glucose-control data examined before 3 months after the administration SGLT2i...
Abstract Aims Few studies have examined the incidence, prevalence, survival rate and death risk for non‐rheumatic rheumatic aortic stenosis (AS; RAS), insufficiency (AR; RAR) with (ASAR; RASAR). This study aims to identify epidemiology of AS, AR, ASAR, RAS, RAR RASAR. Methods results Data were collected from newly diagnosed valve disorders (AVD, ICD‐10: I35 I06, n = 101 895, female: male 6:4) including RASAR, excluding congenital heart disease. The data sourced National Health Insurance...
Abstract Marfan syndrome (MFS) is a genetic disorder caused by an FBN1 variant and diagnosed based on the revised Ghent criteria, which incorporate clinical manifestations testing. Up-to-date interpretation crucial for proper diagnosis management of MFS; however, some variants uncertain significance (VUSs) remain inconclusive despite applying Clinical Genome Resource (ClinGen) -specific guideline. Recently, ClinGen guidance PP1/BS4 co-segregation PP4 phenotype specificity criteria (new...
Determinants of Brachial-Ankle Pulse Wave Velocity and Carotid-Femoral in Healthy KoreansThe aim this study was to determine the normal value brachial-ankle pulse wave velocity (baPWV) carotid-femoral (cfPWV) according age group, gender, presence cardiovascular risk factors healthy Koreans, investigate association between PWV such as prehypertension, dyslipidemia, smoking, obesity.We measured an arterial stiffness 110 subjects who were 20 69 yr-old with no evidence disease, cerebrovascular...
Fragmented QRS complex (fQRS) on 12-lead ECG, a marker of myocardial scar, is predictor arrhythmic events in patients with ischemic and nonischemic cardiomyopathy. We investigated whether the presence fQRS associated severity anomaly increased adult Ebstein (EA).In 51 consecutive EA (median age, 37 years; 18 males), index calculated from echocardiographic data clinical were analyzed. The extent each patient was measured by counting number ECG leads showing fQRS. There 35 (68.6%) (fQRS group)...
This study investigated the prevalence and patterns of lifestyle risk behaviors in Korean adults.We utilized data from Fourth Korea National Health Nutrition Examination Survey for 14,833 adults (>20 years age). We used association rule mining to analyze by characterizing non-adherence public health recommendations related Alameda 7 behaviors. The variables were current smoking, heavy drinking, physical inactivity, obesity, inadequate sleep, breakfast skipping, frequent...
Objective—Increased risk of cardiovascular disease in patients with chronic renal failure (CRF) has been explained by accelerated atherosclerosis and impaired angiogenesis, which endothelial progenitor cells (EPCs) may play key roles. We hypothesized that altered EPC biology contribute to the pathophysiology CRF. Methods Results—EPCs were isolated from CRF on maintenance hemodialysis (n44) a normal control group (n30). showed markedly decreased numbers (44.6%) colonies (75.3%) when compared...
The aims of this study are to examine the prevalence chronic kidney disease (CKD) with metabolic syndrome (MS) and investigate association between CKD MS after adjustment for socioeconomic position health behavior factor.The random sample used in included 5136 Korean subjects ≥20 years age. We divided into two groups based on presence MS, which criteria described NCEP ATP III International Diabetes Federation were used. Also, was defined as an estimated glomerular filtration rate <60...
Abstract Recently, a revised Ghent nosology has been established for the diagnosis of Marfan syndrome (MFS) that puts more weight on aortic root aneurysm and ectopia lentis. We compared application nosologies in adult Korean patients whom there is suspicion MFS. From January 1995 to June 2010, we enrolled 106 older than 20 years was MFS, who had undergone genetic analysis fibrillin‐1 gene ( FBN1 ). Of patients, 86 (81%) fulfilled criteria nosology, 84 (79%) met nosology. The two criteria,...
Abstract Aim Chronic periaortitis ( CP ) is a disease characterized by fibro‐inflammatory periaortic cuff and adventitia‐predominant fibrosis. encompasses idiopathic retroperitoneal fibrosis inflammatory abdominal aortic aneurysm AAA ), recent studies have documented overlap between immunoglobulin G4‐related (IgG4‐ RD ). This study aimed to investigate clinical characteristics treatment outcomes of patients with . Method were identified retrospective review 1245 International Classification...