A5102909171- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Infectious Diseases and Mycology
- Infectious Diseases and Tuberculosis
- Tracheal and airway disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Diagnosis and treatment of tuberculosis
- Pneumonia and Respiratory Infections
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Diagnosis and Treatment
- Quinazolinone synthesis and applications
- Respiratory Support and Mechanisms
- Vascular Anomalies and Treatments
- Actinomycetales infections and treatment
- Esophageal and GI Pathology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pleural and Pulmonary Diseases
- Antifungal resistance and susceptibility
- Cystic Fibrosis Research Advances
- Sepsis Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Medical Imaging and Pathology Studies
- Helicobacter pylori-related gastroenterology studies
- Fungal Infections and Studies
- Salivary Gland Tumors Diagnosis and Treatment
Samsung Medical Center
2012-2021
Sungkyunkwan University
2012-2021
Seoul National University
2011-2019
Seoul National University Bundang Hospital
2019
ORCID
2019
Pulmonary and Critical Care Associates
2009-2018
Weatherford College
2014
Yonsei University
2012
Seoul Medical Center
2008-2012
Pusan National University
2011
Delamanid (OPC-67683), a nitro-dihydro-imidazooxazole derivative, is new antituberculosis medication that inhibits mycolic acid synthesis and has shown potent in vitro vivo activity against drug-resistant strains of Mycobacterium tuberculosis.
Rationale: Mycobacterium massiliense has been recognized as a separate species from abscessus; however, little is known regarding the clinical impact of this differentiation.Objectives: To compare features and treatment outcomes between patients with M. abscessus lung disease those disease.Methods: We performed molecular identification stored isolates complex compared characteristics 64 81 disease.Measurements Main Results: The radiographic manifestations caused by each were similar....
Rationale: The optimal therapeutic regimen and duration of treatment for Mycobacterium abscessus lung disease is not well established.Objectives: To assess the efficacy a standardized combination antibiotic therapy M. disease.Methods: Sixty-five patients (11 males, 55 females, median age yr) with were treated clarithromycin, ciprofloxacin, doxycycline, together an initial amikacin cefoxitin first 4 weeks hospitalization.Measurements Main Results: Treatment response rates 83% symptoms 74%...
Abstract Background Treatment outcomes of patients with Mycobacterium abscessus subspecies lung disease are poor, and the microbial characteristics associated treatment have not been studied systematically. The purpose this study was to identify associations between in M. disease. Methods Sixty-seven consecutive undergoing antibiotic for ≥12 months January 2002 December 2012 were included. Morphotypic genetic analyses performed on isolates from 44 patients. Results Final sputum conversion...
The effect of the clinical phenotype Mycobacterium avium complex (MAC) lung disease on treatment outcome and redevelopment nontuberculous mycobacterial (NTM) after completion has not been studied systematically.We evaluated 481 treatment-naïve patients with MAC who underwent antibiotic for ≥12 months between January 2002 December 2013.Out patients, 278 (58%) had noncavitary nodular bronchiectatic (NB) disease, 80 (17%) cavitary NB 123 (25%) fibrocavitary disease. Favourable was higher in...
The increasing worldwide incidence of extensively drug-resistant tuberculosis (XDR-TB) has emerged as a threat to public health and (TB) control. Treatment outcomes have varied among studies, data on long-term survival are still scarce.To retrospectively assess the burden, clinical characteristics, treatment outcomes, rate patients with XDR-TB in cohort HIV-negative multidrug-resistant (MDR-TB) South Korea.Medical records were reviewed newly diagnosed or retreated for MDR-TB from 2000 2002....
Rationale: Macrolides, such as clarithromycin (CLR) and azithromycin (AZM), are frequently the only oral antibiotics that active against Mycobacterium abscessus M. massiliense infections.Objectives: To compare activity of CLR AZM in experimental models.Methods: We compared treatment efficacies determined correlation between efficacy induced erythromycin ribosome methyltransferase gene (erm)(41) expression models infections.Measurements Main Results: In all tested isolates, a high level...
Multidrug-resistant (MDR) tuberculosis (TB) is more difficult to treat than drug-susceptible TB. To elucidate the optimal therapy for MDR TB, we assessed treatment outcomes and prognostic factors patients with TB.This study included who received an individualized regimen TB at Samsung Medical Center, a tertiary referral hospital in Seoul, Korea, from January 1995 through December 2004. identify related favorable outcomes, univariate comparison multiple logistic regression were performed.Of...
The prevalence and incidence of nontuberculous mycobacterial (NTM) infections increased in South Korea from 2007 to 2016. Annual NTM infection 39.6 cases/100,000 population 2016 annual 19.0 population. Overall for the study period was higher elderly, females, cities.
Although intermittent, three-times-weekly therapy is recommended for the initial treatment of noncavitary nodular bronchiectatic Mycobacterium avium complex (MAC) lung disease, supporting data are limited.To evaluate clinical efficacy intermittent compared with daily MAC disease.A retrospective cohort study 217 patients treatment-naive disease. All received either (n = 99) or 118) that included clarithromycin azithromycin, rifampin, and ethambutol.Modification antibiotic occurred more...
Limited data are available regarding the prognostic factors for patients with nontuberculous mycobacterial pulmonary disease (NTM-PD). We investigated associated long-term mortality in NTM-PD after adjusting individual confounders, including aetiological organism and radiological form. A total of 1445 treatment-naïve who were newly diagnosed between July 1997 December 2013 included. The organisms as follows: Mycobacterium avium (n=655), M. intracellulare (n=487), abscessus (n=129)...
Macrolide antibiotics are key components of the multidrug treatment regimen for treating lung disease (LD) due to Mycobacterium avium complex (MAC). Despite emergence macrolide resistance, limited data available on macrolide-resistant MAC-LD. This study evaluated clinical features and outcomes patients with MAC-LD molecular characteristics isolates. A retrospective review medical records 34 who were diagnosed between January 2002 December 2014 was performed, along genetic analysis 28...