A5060559119- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Organic Electronics and Photovoltaics
- Organic Light-Emitting Diodes Research
- Conducting polymers and applications
- Infectious Diseases and Mycology
- Antibiotic Resistance in Bacteria
- Quantum Dots Synthesis And Properties
- Vibrio bacteria research studies
- Advanced Memory and Neural Computing
- Quinazolinone synthesis and applications
- Advanced Sensor and Energy Harvesting Materials
- Perovskite Materials and Applications
- Carbon and Quantum Dots Applications
- Thin-Film Transistor Technologies
- Pharmaceutical and Antibiotic Environmental Impacts
- Photoreceptor and optogenetics research
- Ginseng Biological Effects and Applications
- Gut microbiota and health
- Organic and Molecular Conductors Research
- Escherichia coli research studies
- Nanocluster Synthesis and Applications
- Plant Pathogenic Bacteria Studies
- Enterobacteriaceae and Cronobacter Research
- Semiconductor materials and interfaces
Samsung Medical Center
2016-2024
Sungkyunkwan University
2012-2024
Hanyang University
2014-2024
Korea University of Science and Technology
2020-2022
Korea Research Institute of Bioscience and Biotechnology
2020-2022
Chonnam National University
2022
Samsung (South Korea)
2011-2016
Kyung Hee University
2014
Institute for Basic Science
2014
Korea University
2012
Abstract Background Treatment outcomes of patients with Mycobacterium abscessus subspecies lung disease are poor, and the microbial characteristics associated treatment have not been studied systematically. The purpose this study was to identify associations between in M. disease. Methods Sixty-seven consecutive undergoing antibiotic for ≥12 months January 2002 December 2012 were included. Morphotypic genetic analyses performed on isolates from 44 patients. Results Final sputum conversion...
Macrolide antibiotics are key components of the multidrug treatment regimen for treating lung disease (LD) due to Mycobacterium avium complex (MAC). Despite emergence macrolide resistance, limited data available on macrolide-resistant MAC-LD. This study evaluated clinical features and outcomes patients with MAC-LD molecular characteristics isolates. A retrospective review medical records 34 who were diagnosed between January 2002 December 2014 was performed, along genetic analysis 28...
Patients with lung disease caused by Mycobacterium abscessus subsp. (here M. abscessus) typically have poor treatment outcomes. Although clofazimine (CFZ) has been increasingly used in the of clinical practice, there are no reported data on its effectiveness for this disease. This study sought to evaluate efficacy a CFZ-containing regimen We performed retrospective review medical records 42 patients who were treated regimens between November 2013 and January 2015. CFZ was administered...
ABSTRACT In this surveillance study, we identified the genotypes, carbapenem resistance determinants, and structural variations of AbaR-type islands among carbapenem-resistant Acinetobacter baumannii (CRAB) isolates from nine Asian locales. Clonal complex 92 (CC92), corresponding to global clone 2 (GC2), was most prevalent in locales (83/108 isolates; 76.9%). CC108, or GC1, a predominant India. OXA-23 oxacillinase detected CRAB except Taiwan. bla OXA-24 found AbaR4-type islands, which were...
We evaluated the GenoType NTM-DR (NTM-DR) line probe assay for identifying Mycobacterium avium complex (MAC) species and abscessus subspecies determining clarithromycin amikacin resistance. Thirty-eight reference strains 145 clinical isolates (58 MAC 87 M. isolates), including 54 clarithromycin- and/or amikacin-resistant strains, were involved.
We evaluated the in vitro activities of antimicrobial drugs bedaquiline and delamanid against major pathogenic nontuberculous mycobacteria (NTM). Delamanid showed high MIC values for all NTM except Mycobacterium kansasii . However, low NTM, including avium complex, abscessus subsp. , M. massiliense
ABSTRACT Macrolide antibiotics are mainstays in the treatment of lung disease due to Mycobacterium abscessus complex. Although previous studies have reported development acquired macrolide resistance this species, limited data available on outcomes macrolide-resistant subsp. . This study evaluated clinical features, outcomes, and molecular characteristics isolates M. We performed a retrospective review medical records genetic analysis from 13 patients who had between November 2006 March...
We investigated the genetic background and microbiological features of T6SS-positive Acinetobacter baumannii isolates clinical impact T6SS in patients with A. bacteremia. One hundred 62 from bacteremia 2 tertiary-care hospitals Korea were included this study. Approximately one-third (51/162, 31.5%) possessed hcp gene, hcp-positive found several genotypes multilocus sequence typing. The expression secretion Hcp protein varied among isolates. detectable (T6SS+) could better outcompete...
Abstract We evaluated the association between 16S rRNA gene ( rrs ) mutations and susceptibility in clinical isolates of amikacin-resistant nontuberculous mycobacteria (NTM) NTM-pulmonary disease (PD) patients. Susceptibility was retested for 134 (minimum inhibitory concentration [MIC] ≥ 64 µg/ml) from 86 Amikacin resistance reconfirmed 102 NTM 62 patients with either Mycobacterium avium complex-PD (MAC-PD) (n = 54) or M. abscessus -PD 8). MICs were 318 single colonies these isolates. For 54...
To analyze the characteristics of sputum microbiota patients with nontuberculous mycobacteria pulmonary disease (NTM-PD) based on treatment status. Twenty-eight samples from 14 NTM-PD, including microbiologically cured group (7 at baseline and 7 during follow-up) treatment-refractory were included in this study. Bacterial was analyzed by sequencing V3-V4 region 16S rRNA gene. Among patients, most had infections Mycobacterium avium complex (n = 6), followed abscessus 5); three exhibited mixed...
Acinetobacter species have emerged as opportunistic nosocomial pathogens in intensive care units. Epidemic spread and outbreaks of multidrug-resistant or carbapenem-resistant baumannii infections been described worldwide. Species distribution, antimicrobial resistance genotypes were investigated for isolates collected from a single institution Korea over 7 years. Two hundred eighty-seven patients with bloodstream one Korean hospital 2003 to 2010. Most them belonged the...
We report on the enhanced conductivity of benzoic-acid-treated poly(3,4-ethlenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) electrode for use in highly flexible, organic light-emitting devices (OLEDs). The PEDOT:PSS increased from 1 to 1583.2 S/cm, comparison with that pristine electrode, due a complex factor H+ mole % and dielectric constant benzoic solution. Among post-treatment methods electrodes, operating voltage at 1000 cd/m2 OLEDs fabricated utilizing acid treatment has lowest...
Background The role of bacterial microbiota in the pathogenesis nontuberculous mycobacterial pulmonary disease (NTM-PD) is unclear. We aimed to compare microbiome disease-invaded lesions and non-invaded lung tissue from NTM-PD patients. Methods analyzed tissues 23 patients who underwent surgical resection. Lung were collected pairs each patient, with one sample a disease-involved site other non-involved site. libraries constructed using 16S rRNA gene sequences (V3–V4 regions). Results...
Natural, organic, materials-based artificial synaptic devices have been in the spotlight for wearable/flexible due to their lightweight, biocompatibility, and scalability. In this study, an electronic memristive device based on agarose extracted from plants Rhodophyceae class was fabricated, its memory characteristics analog data processing capabilities were evaluated. The Al/agarose@gold nanoparticle (AuNP) film/indium-tin-oxide (ITO)-structured exhibited reliable resistive switching with...
ABSTRACT Macrolide antibiotics are cornerstones in the treatment of Mycobacterium massiliense lung disease. Despite emergence resistance, limited data on macrolide-resistant M . disease available. This study evaluated clinical features and outcomes patients molecular characteristics isolates. We performed a retrospective review medical records genetic analyses isolates from 15 who had between September 2005 February 2015. Nine (60%) nodular bronchiectatic form disease, six (40%)...
Abstract Background We evaluated whether the sputum bacterial microbiome differs between nontuberculous mycobacteria pulmonary disease (NTM-PD) patients with stable not requiring antibiotic treatment and those antibiotics. Methods collected samples from 21 clinically NTM-PD (stable group) 14 needing (treatment group). also obtained 13 follow-up group. analyzed 48 using 16S rRNA gene sequencing (V3–V4 region) compared groups. Results In linear discriminant analysis effect size (LEfSe)...
Mycobacterium avium complex pulmonary disease (MAC-PD) has a heterogeneous clinical course. However, immune profiles associated with MAC-PD course are limited. We performed single-cell RNA sequencing of peripheral blood mononuclear cells from 21 patients divided into three courses: group A, spontaneous culture conversion; B, stable without antibiotic treatment; and C, progressive treatment. A lower proportion NK higher monocytes were noted in C compared to combined groups B. The classical...
Organic light-emitting devices (OLEDs) were fabricated utilizing Au-ZnO nanocomposites (NCs) with various Au nanoparticles (NPs) concentrations synthesized by using a sol-gel process to enhance their current efficiency, and these compared OLEDs ZnO NPs only. The electroluminescence intensity of the NCs at wavelength 535 nm was significantly larger than that factor 1.89. efficiency 10 wt. % 1000 cd/m2 higher 16.7 cd/A NPs. This increase in attributed an enhancement out-coupling due existence...
In this study, we analyzed the frequency of AbGRI1-type genomic island (GI) and its association with genotypes. We obtained 130 Acinetobacter baumannii isolates causing bloodstream infections from patients in South Korea. Antimicrobial susceptibility testing multilocus sequence typing were performed. The presence GIs their structures determined by sequential PCR sequencing. Ninety-eight (75.3%) representing 14 types (STs) belonged to clonal complex 208 (CC208), corresponding global clone 2...