Mycobacterium avium complex pulmonary disease (MAC-PD) has a heterogeneous clinical course. However, immune profiles associated with MAC-PD course are limited. We performed single-cell RNA sequencing of peripheral blood mononuclear cells from 21 patients divided into three courses: group A, spontaneous culture conversion; B, stable without antibiotic treatment; and C, progressive treatment. A lower proportion NK higher monocytes were noted in C compared to combined groups B. The classical...

Despite the importance of comorbid ischemic heart disease (IHD) in prognosis asthma, long-term impact coronavirus 2019 (COVID-19) on IHD adults with asthma remains unclear. This study investigated effects COVID-19 risk individuals particularly regarding severity. Using Korean National Health Insurance Service claims database, we identified who had recovered from between October 8, 2020, and December 31, 2021 (n = 8,011) 1:1 propensity score-matched controls 8,011). The incidence were...

Acute lung injury (ALI) is one of the most serious pulmonary complications following resection. Despite known beneficial effects corticosteroid treatment for postoperative ALI, limited data are available regarding duration. This study aimed to evaluate a short-course in patients with ALI resection surgery cancer. retrospective observational included 91 who were treated corticosteroids among 7,317 underwent cancer between January 2017 and March 2021. Patients divided into two groups, short...

ABSTRACT Despite guideline-based therapy, some patients with Mycobacterium avium complex pulmonary disease (MAC-PD) experience treatment failure. We analyzed the clinical courses of 271 treatment-refractory MAC-PD who discontinued therapy after at least 12 months. Patients were categorized into two groups—the retreatment group, resumed antibiotics due to or radiological deterioration, and stable did not require antibiotics. Of study patients, 138 (51%) in whereas 133 (49%) group. In...

Inhaler therapy and physical activity (PA) are important methods of chronic obstructive pulmonary disease (COPD) management. This study aimed to investigate the additional benefit moderate-to-vigorous PA (MVPA) in patients with COPD using a long-acting beta-agonists (LABA)/long-acting muscarinic antagonist (LAMA) combination. We emulated target trial estimate MVPA dual ultra-long-acting bronchodilators. enrolled aged ≥ 40 who were diagnosed between 2014 2018, initiated LABA/LAMA combination,...

The chronic obstructive pulmonary disease (COPD) assessment test (CAT) is widely used to assess the impact of COPD symptoms on health status. Whilst CAT consists eight different items, details distribution each item are limited. This study aimed investigate and clinical implication item, stratified by severity group, in stable patients.

Limited data are available regarding the impact of antibiotic maintenance period on redevelopment nontuberculous mycobacteria-pulmonary disease (NTM-PD) after microbiological cure Mycobacterium avium complex (MAC)-PD. This retrospective study included 631 MAC-PD patients who achieved between 1994 and 2021. Data period, defined as time culture conversion treatment completion, were collected. Redevelopment, subsequent diagnosis NTM-PD regardless causative organism cure, was investigated....

Malignant pulmonary granular cell tumor (GCT) is extremely rare and difficult to distinguish from benign GCT. Most GCTs are neural-type express S-100. However, a small subset of tumors sub-classified as the non-neural type do not We report case malignant non-neural-type GCT in lungs. A 77-year-old woman felt chest discomfort dyspnea July 2019. She had never smoked no medical history other than hypertension diabetes mellitus. was initially evaluated at local hospital. Flexible bronchoscopy...

Tracheobronchopathia osteochondroplastica (TPO) is an idiopathic disease involving the cartilage rings of large airway, characterized by submucosal calcified nodules. Localized tracheobronchial amyloidosis (TBA) another rare with localized amyloid deposits in tree. The two diseases rarely coincide, and only a few case reports series have been reported. A patient dyspnea was referred to our clinic for suspicion TBA. Chest computed tomography (CT) scan showed marked thickening wall...

Clinical MicrobiologyThe prevalence of nontuberculous mycobacteria (NTM)-pulmonary disease (PD) is increasing worldwide [1].Major pathogens causing NTM-PD include the slowly growing (SGM) species Mycobacterium avium complex (MAC, mainly composed M. and intracellulare) kansasii, as well rapidly (RGM) abscessus subspecies (hereafter, abscessus), massiliense massiliense), fortuitum [2,3].Treatment guidelines for recommend macrolide (mainly clarithromycin)-based multidrug therapy [4,5].In...

The next diagnostic step in cases of indeterminate radial probe endobronchial ultrasound (radial EBUS)-guided biopsy results remains uncertain. This study aimed to identify risk factors for malignancy based on clinical findings, chest computed tomography (CT), and EBUS images, estimate the lung nodules that showed EBUS-guided by constructing a nomogram. retrospective included 157 patients with an initial performed at Samsung Medical Center from January 2017 December 2018, but definitive...

Bronchopleural fistula (BPF) is a communication between the pleural space and bronchial tree. Herein, we report patient with persistent air leak after necrotizing pneumonia, where tract of BPF was not apparent in computed tomography (CT). Despite control infection, watchful observation, repetitive procedures, surgery, resolved. This led to consideration endobronchial valve (EBV) placement. After identifying segment leading indigo carmine, precise occlusion lingular division left upper lobe...

Background/Aim: Although the importance of low-dose computed tomography (LDCT) screening is increasingly emphasized and implemented, many lung cancers continue to be incidentally detected during routine medical practices, data on cancer (IDLC) remain scarce. This study aimed investigate clinical characteristics prognosis IDLCs by comparing them with screening-detected (SDLCs). Patients Methods: In this retrospective study, subjects cT1 (≤3 cm) pulmonary nodules baseline (CT), later...

Bronchiectasis is a chronic respiratory disease characterized by abnormal dilation of the bronchi that causes cough, sputum, and recurrent infections. As it may be associated with various or systemic diseases, critical aspect managing bronchiectasis to identify underlying cause. Immunodeficiency rare but important cause bronchiectasis, its treatability significant trait for management. While primary immunodeficiencies in are well recognized, secondary remain under-reported under-researched....

The chronic obstructive pulmonary disease (COPD) assessment test (CAT) measures the health status of patients with COPD. We aimed to investigate change in individual CAT scores after short-term bronchodilator therapy among treatment-naïve COPD.Data from 148 newly diagnosed COPD between January 2016 and April 2020 were retrospectively analyzed. compared score, modified Medical Research Council (mMRC) dyspnea grade, forced expiratory volume 1 s (FEV1) before (6 ± 2 months) therapy. analyzed...

Despite the importance of influenza vaccination, its rates in subjects with asthma are suboptimal, especially young population.Among 72,843 adults aged ⩾18 years from Korea National Health and Nutrition Examination Survey conducted between 2010 2019, 1643 were included. The yearly trends factors associated vaccination analyzed asthma. In addition, stratified analyses performed by age group (<65 versus ⩾65 years).During study period, overall rate among fluctuated 51.0% to 64.3%, a...

This study investigated whether radiomic features extracted from radial-probe endobronchial ultrasound (radial EBUS) images can assist in decision-making for subsequent clinical management cases with indeterminate pathologic results.A total of 494 patients who underwent radial EBUS biopsy lung nodules between January 2017 and December 2018 were allocated to our training set. For the validation set, 229 results 2019 April 2020 used. A multivariate logistic regression analysis was used feature...

Tracheobronchopathia osteochondroplastica (TPO) is an idiopathic disease involving the cartilage rings of large airway, characterized by submucosal calcified nodules. Localized tracheobronchial amyloidosis (TBA) another rare with localized amyloid deposits in tree. The two diseases rarely coincide, and only a few case reports series have been reported. A patient dyspnea was referred to our clinic for suspicion TBA. Chest computed tomography (CT) scan showed marked thickening wall...

Abstract Hypersensitivity pneumonitis (HP) is an interstitial lung disease (ILD) that results from immune-mediated reaction involving various antigens in susceptible individuals. However, the clinical characteristics and outcomes of HP South Korea are not well understood. This retrospective study analyzed 43 patients with pathologically proven at a single tertiary hospital between 1996 2020. In addition, case reports published were collected. The characteristics, etiologies, treatment, our...

Background: Mycobacterium Avium complex pulmonary disease (MAC-PD) has a heterogeneous clinical course from spontaneous culture conversion to deterioration despite antibiotic treatment. However, immunological factors associated with the of MAC-PD are not well known.Methods: We performed single-cell RNA sequencing (scRNA-seq) peripheral blood mononuclear cells 21 patients divided into three courses: group A, conversion; B, stable without treatment; and C, progressive Findings: The numbers T...