A5100599598- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Dialysis and Renal Disease Management
- Renal Diseases and Glomerulopathies
- Nanoplatforms for cancer theranostics
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Renal and Vascular Pathologies
- Blood Pressure and Hypertension Studies
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Renin-Angiotensin System Studies
- Hormonal Regulation and Hypertension
- Luminescence and Fluorescent Materials
- Carbon and Quantum Dots Applications
- Organ Donation and Transplantation
- Graphene and Nanomaterials Applications
- Cardiac Arrest and Resuscitation
- Pediatric Urology and Nephrology Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Vasculitis and related conditions
- Parathyroid Disorders and Treatments
- Sepsis Diagnosis and Treatment
- Metabolism and Genetic Disorders
Sungkyunkwan University
2016-2025
Samsung Medical Center
2016-2025
Pediatric Nephrology of Alabama
2018-2023
Weatherford College
2020
Chungbuk National University Hospital
2019-2020
Bucheon St. Mary's Hospital
2020
Catholic University of Korea
2020
Suwon Research Institute
2015-2019
Government of the Republic of Korea
2017-2019
Theranostics (New Zealand)
2019
Background/Aims The gastrointestinal (GI) tract often becomes involved in patients with systemic amyloidosis. As few GI amyloidosis data have been reported, we describe the clinical features and outcomes of pathologically proven Methods We identified 155 diagnosed between April 1995 2013. Twenty-four (15.5%) were using associated symptoms, diagnoses confirmed by direct biopsy. Results Among 24 patients, 20 (83.3%) had light chain (AL), three (12.5%) amyloid A, one (4.2%)...
Serum uric acid is associated with cardiovascular disease. However, the independent role of in development disease uncertain. This study examined cross-sectional association serum level microalbuminuria among 6771 subjects without diabetes or hypertension. Blood pressure was categorized as prehypertension (systolic blood pressure, 120 to 140 mm Hg diastolic 80 90 Hg) and normotension <120 <80 Hg). Microalbuminuria found 4.0% normotensive (n=4819) 7.9% prehypertensive (n=1952)....
Despite the tremendous progress that photothermal therapy (PTT) has recently achieved, it still a long way to go gain effective targeted ablation of tumor cells. Driven by this need, we describe new class therapeutic agents for cancer cells with pH responsive bioimaging using near-infrared dye (NIR) IR825, conjugated poly(ethylene glycol)-g-poly(dimethylaminoethyl methacrylate) (PEG-g-PDMA, PgP), and hyaluronic acid (HA) anchored reduced graphene oxide (rGO) hybrid nanoparticles. The...
Mesoporous silica has received considerable attention as a drug delivery vehicle because of its large surface area and pore volume for loading drugs biomolecules. Recently, mesoporous microparticles have shown potential three-dimensional vaccine platform modulating dendritic cells via spontaneous assembly in specific region after subcutaneous injection. For further vivo applications, the biodegradation behavior must be studied known. Until now, most studies focused on nanoparticles (MSNs);...
A new synthesis strategy for ordered mesoporous carbon with precisely controllable pore sizes in the range of 3 to 10 nm using an inorganic expanding agent is demonstrated. The mechanism involves formation borosilicate and boron oxide nanolayers between framework silica surface within mesopores template caused by spontaneous phase separation subsequent solid state reaction during carbonization. Supporting information this article available on WWW under...
Mannitol, an osmotic agent used to decrease intracranial pressure, can cause acute kidney injury (AKI). The objectives of this study were assess the impact mannitol on incidence and severity AKI identify risk factors outcome for in patients with hemorrhage (ICH).The authors retrospectively evaluated 153 adult who received infusion after ICH between January 2005 December 2009 neurosurgical intensive care unit. Multivariate analysis was evaluate ICH. Based odds ratio, weighted scores assigned...
<italic>In situ</italic> synthesis of fluorescence carbon nanoparticles (FCNs) for target bioimaging applications derived from biocompatible hyaluronic acid (HA) without conjugation.
We developed nanoparticles comprising a photothermal dye (IR825)-loaded carbonized zwitterionic polymer [FNP-I] as "switch-on" pH-responsive fluorescence probes to sense intracellular cancer cells and for near-infrared (NIR) controllable therapy (PTT) in vivo vitro. The fluorescent "off" of FNP-I was activated after reaching the cell environment, where compartment FNP lost its hydrophobicity induce PTT-mediated heat release IR825 under NIR irradiation tumor. Approximately 100% released from...
Antiviral therapy is an essential treatment for chronic hepatitis B (CHB) infection. Although hypophosphatemia important adverse effect of antiviral agents, its clinical significance remains unclear. We investigated the incidence and consequences in a large cohort CHB patients. This retrospective study included patients who started between 2005 2015 continued it at least 1 year. Patients with decompensated liver cirrhosis, diabetes mellitus, hypertension, concomitant diuretic administration,...
We aimed to compare rescuer fatigue and cardiopulmonary resuscitation (CPR) quality between standard 30:2 CPR (ST-CPR) chest compression only (CO-CPR) performed for 8 minutes on a realistic manikin by following the 2010 guidelines. All 36 volunteers (laypersons; 18 men women) were randomized ST-CPR or CO-CPR at first, then each technique was with 3-hour rest interval. measured mean blood pressure (MBP) of before after performing technique, continuously monitored heart rate (HR) during using...
Abstract Introduction Although the clinical application of procalcitonin (PCT) as an infection marker in patients with impaired renal function (estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m 2 ) has been increasing recently, it is unclear whether PCT more accurate than C-reactive protein (CRP). We investigated value CRP and based on function. Methods From November 2008 to July 2011, a total 493 who simultaneously underwent tests were enrolled. The area under receiver...
Human umbilical cord blood-derived mesenchymal stem cells (HUCB-MSCs) have been studied in several models of immune-mediated disease because their unique immunomodulatory properties. We hypothesized that HUCB-MSCs could suppress the inflammatory response postischemic kidneys and attenuate early renal injury. In 8- to 10-wk-old male C57BL/6 mice, bilateral ischemia-reperfusion injury (IRI) surgery was performed, 1 × 10 6 were injected intraperitoneally 24 h before during reperfusion. Renal...
Despite aggressive application of continuous renal replacement therapy (CRRT) in critically ill patients with acute kidney injury (AKI), there is no consensus on diuretic when discontinuation CRRT attempted. The effect diuretics was evaluated. This retrospective cohort study enrolled 1176 adult who survived for more than 3 days after discontinuing between 2009 and 2014. Patients were categorized depending the re-initiation within or use diuretics. Changes urine output (UO) function outcomes....
With the increasing incidence of breast cancer worldwide, in particular southeast Asia (including Korea), and common use anthracyclines adjuvant metastatic settings, occurrence Hepatitis B virus (HBV) reactivation may develop this patient population. The prophylactic antiviral agents patients result a reduced HBV exacerbation. purpose current study was to assess efficacy lamivudine reducing severity post-operative undergoing doxorubicin-containing chemotherapy. medical records...
Continuous renal replacement therapy (CRRT) has emerged as the preferred dialysis modality for critically ill patients with acute kidney injury. The objectives of this retrospective study were to assess effect nafamostat on circuit patency CRRT and safety regarding bleeding complications in at high risk bleeding. We conducted a 243 started without anticoagulation, was used if hemofilter lifespan less than 12 h. average measured before after drug infusion evaluate efficacy nafamostat....