A5008287980- Radiomics and Machine Learning in Medical Imaging
- Gastric Cancer Management and Outcomes
- Glaucoma and retinal disorders
- Esophageal Cancer Research and Treatment
- Cardiac Arrhythmias and Treatments
- Ophthalmology and Visual Impairment Studies
- Intraocular Surgery and Lenses
- Lung Cancer Treatments and Mutations
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Drug-Induced Hepatotoxicity and Protection
- Advanced Causal Inference Techniques
- Nutrition, Health and Food Behavior
- Voice and Speech Disorders
- Mosquito-borne diseases and control
- Ocular Surface and Contact Lens
- Hereditary Neurological Disorders
- Lung Cancer Research Studies
- Head and Neck Cancer Studies
- Dysphagia Assessment and Management
- Ferroptosis and cancer prognosis
- Neurogenetic and Muscular Disorders Research
- Herpesvirus Infections and Treatments
- Pancreatic and Hepatic Oncology Research
Sungkyunkwan University
2017-2025
Samsung (South Korea)
2019-2025
Samsung Medical Center
2017-2025
Background The current standard treatment for patients with inoperable, locally advanced esophageal squamous cell carcinoma (ESCC) is definitive concurrent chemoradiotherapy (CCRT). Methods Patients ESCC received 2 cycles of 5‐fluorouracil, cisplatin, durvalumab, and tremelimumab every 3 weeks radiation therapy (60.2 or 64.5 grays). After completing CCRT plus immunotherapy, consolidative durvalumab followed by monotherapy 4 years after enrollment. Their survival outcomes were compared those...
Importance Over the past 10 years, treatment of non–small cell lung cancer (NSCLC) has been continually revolutionized. However, standard clinical trials may not reflect current multiple lines and corresponding outcomes in a timely manner. Objective To investigate associated with new NSCLC setting. Design, Setting, Participants This cohort study included patients between January 1, 2010, November 30, 2020, who received any anticancer at Samsung Medical Center Korea. Data were analyzed from...
Abstract Background In this study, the risk of dementia in patients with a history herpes simplex virus (HSV) or varicella zoster (VZV) infection was evaluated. Methods This nationwide cohort study used data from Korean National Health Insurance Service collected between 2006 and 2017. A total 752,205 subjects ≥ 45 years age not diagnosed until were included. multivariate Cox regression model, adjusted for age, sex, other comorbidities, to assess hazard ratio (HR) based on VZV HSV infection....
Despite improvements in the surgical and medical treatment of papillary thyroid carcinoma (PTC), subsets patients suffer from structural recurrence after initial treatment. This study evaluated timing patterns completely resected PTC patients.A retrospective review a prospectively maintained cancer database was performed. The were reviewed 2250 with >1 cm who achieved complete remission total thyroidectomy and/or radioactive iodine Univariate multivariate analyses performed to identify...
Antiviral therapy is an essential treatment for chronic hepatitis B (CHB) infection. Although hypophosphatemia important adverse effect of antiviral agents, its clinical significance remains unclear. We investigated the incidence and consequences in a large cohort CHB patients. This retrospective study included patients who started between 2005 2015 continued it at least 1 year. Patients with decompensated liver cirrhosis, diabetes mellitus, hypertension, concomitant diuretic administration,...
To provide the statistical predictive model for neoplastic potential of gallbladder polyp (GBP).Many studies have attempted to define risk factors GBP. It remains difficult precisely adapt reported decision surgery. Estimating probability GBP using a combination several before surgical resection would be useful in patient consultation.We collected data patients confirmed as through cholecystectomy at Samsung Medical Center between January 1997 and March 2015. Those with definite evidence...
Abstract Background Surgery is the primary treatment for non-small cell lung cancer (NSCLC), but microscopic residual disease may be unavoidable. Preclinical studies have shown that volatile anesthetics might suppress host immunity and promote a pro-malignant environment supports proliferation, migration, angiogenesis, whereas propofol preserve cell-mediated inhibit tumor angiogenesis. However, clinical evidence propofol-based total intravenous anesthesia (TIVA) can reduce recurrence after...
Background: We investigate the incidence and characteristics of IOL dislocation among pseudophakic population after phacoemulsification. Methods: National data were collected from health claims recorded with Health Insurance Review Assessment Service South Korea 2009 to 2016. Pseudophakic patients aged 40 years or older included. The estimates phacoemulsification analyzed, cumulative probabilities general calculated as a proportion. Results: Of 51,307,821 total subjects, 25,271,917 whom...
Introduction The long-term effects of fenestration in patients with Fontan circulation remain unclear. We aim to evaluate the impact on early and late outcomes extracardiac (ECF) using a propensity score matching analysis. Methods performed an extensive retrospective multicenter clinical data review Korean registry included 1,233 surgical ECF (779 fenestrated, 454 non-fenestrated). Demographics, baseline, follow-up were collected comprehensively analyzed. Patients divided into two groups...
Abstract We investigated the effect of visual impairment (VI) on dementia development in a national cohort. In this 12-year nationwide population-based retrospective cohort study, data were collected from National Health Insurance Cooperation South Korea 2002 to 2017, comprising 799,074 subjects selected dementia-free representative Korean population. Crude hazard ratios (HRs) as well age- and sex-adjusted HRs confidence intervals (CIs) for estimated using multivariable Cox regression...
<title>Abstract</title> <bold>Background </bold>This is the first gene therapy trial in patients with Charcot-Marie-Tooth disease type 1A (CMT1A). Intramuscular injectionsof VM202, a plasmid DNA encoding human hepatocyte growth factor, was safe, tolerable and potentially effective CMT1A. <bold>Methods</bold> This study phase 1/2a, nonrandomized controlled trial. Thirteen CMT1A were screened, 12 consented enrolled between September 2020 November 2020. Patients received intramuscular...
<title>Abstract</title> The tumor microenvironment (TME) consists of tumor-associated stroma and infiltrating lymphocytes (TIL). Assessment tumor-stroma ratio (TSR) TIL in the histopathological specimens can provide important prognostic information various diverse solid tumors including gastric cancer (GC). However, implementation as a routine clinical biomarker has not been developed. In 320 GC patients, Generative Adversarial Network (GAN)-based virtual cytokeratin leukocyte common antigen...
Background/Aim: Invasive stratified mucin-producing carcinoma (ISMC) is a rare but aggressive variant of endocervical adenocarcinoma (EAC). The aim this study was to investigate the differences in clinicopathological features, patient outcomes, and programmed death-ligand 1 (PD-L1) expression among ISMC, usual-type EAC (UEA), gastric-type (GEA). Patients Methods: PD-L1 22C3 immunostaining performed using 20 ISMCs, UEAs, GEAs. Combined positive score (CPS) method used assess immunoreactivity....
Sodium–glucose cotransporter 2 (SGLT-2) inhibitors are the only medications that improve clinical outcomes regardless of baseline left ventricular ejection fraction. Despite recognized effectiveness SGLT-2 inhibitors, there remains a paucity research on discontinuation these medications. The objective this study is to analyze rate evaluate impact outcome, and identify factors associated with discontinuation. From 2015 2021, 775 heart failure patients prescribed an inhibitor were...
Abstract The study aimed to investigate the relationship between use of COX inhibitors and risk hepatocellular carcinoma (HCC) development in patients with chronic hepatitis B (CHB) using a nationwide population‐based data. A nested case‐control was conducted National Health Insurance Service–National Sample Cohort (NHIS‐NSC) from 2002 2013 Korea. We compared HCC cases matched controls by categorizing 5 groups according cumulative defined daily dose (cDDD, <28, 28‐90, 91‐180, 181‐360,...
Background In patients with hepatocellular carcinoma (HCC) who undergo follow-up CT after treatment, the benefit of routinely including pelvic coverage is not well substantiated. Purpose To investigate added value at liver in detecting metastasis or incidental tumors treated for HCC. Materials and Methods This retrospective study included were diagnosed HCC between January 2016 December 2017 followed up treatment. Cumulative rates extrahepatic metastasis, isolated tumor estimated by using...
Abstract In this paper, we investigate K ‐group comparisons on survival endpoints for observational studies. clinical databases studies, treatment patients are chosen with probabilities varying depending their baseline characteristics. This often results in noncomparable groups because of imbalance characteristics among groups. order to overcome issue, conduct propensity analysis and match the subjects similar scores across or compare weighted group means (or curves censored outcome...
The objective of this study was to evaluate the efficacy and safety totally thoracoscopic ablation (TTA) in patients with recurrent atrial fibrillation (AF) after radiofrequency catheter (RFCA).From February 2012 May 2020, 460 who underwent TTA were classified into two groups: CA (presence RFCA history, n = 74) nCA groups (absence 386). Inverse probability treatment weighting (IPTW) analyses used adjust for confounders. primary endpoint freedom from composite AF, typical flutter, atypical...
9133 Background: Over the past 10 years, treatment of non-small cell lung cancer (NSCLC) has been continuously revolutionized. This study evaluated how this revolution improved outcomes in real-world. Methods: We collected clinical, pathological, and molecular data patient with NSCLC using an house real-time updated cohort (ROOT-HEALTH). The primary objective was 3-year survival (OS3) rate by clinical stage, histology, driver mutations including EGFR, ALK, ROS1, RET, MET exon 14 skipping,...