A5046808235- Respiratory Support and Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Airway Management and Intubation Techniques
- Anesthesia and Pain Management
- SARS-CoV-2 and COVID-19 Research
- Nitric Oxide and Endothelin Effects
- Hemodynamic Monitoring and Therapy
- Nausea and vomiting management
- Pulmonary Hypertension Research and Treatments
- COVID-19 Clinical Research Studies
- Intensive Care Unit Cognitive Disorders
- Tracheal and airway disorders
- Renal function and acid-base balance
- Viral Infections and Immunology Research
- Lung Cancer Diagnosis and Treatment
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Neuroscience of respiration and sleep
- Thermal Regulation in Medicine
- Neonatal Respiratory Health Research
- Anesthesia and Sedative Agents
- COVID-19 and healthcare impacts
- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Memorial Sloan Kettering Cancer Center
2014-2024
Memorial Hospital
2023
American Heart Association
2022
Cornell University
2020
Harvard University
2005
Brigham and Women's Hospital
2005
European Society of Anaesthesiology
2003
SUNY Upstate Medical University
2001-2002
Syracuse University
1998-1999
Istituti di Ricovero e Cura a Carattere Scientifico
1996-1998
To assess the possible differences in respiratory mechanics between acute distress syndrome (ARDS) originating from pulmonary disease (ARDSp) and that extrapulmonary (ARDSexp) we measured total system (Est,rs), chest wall (Est,w) lung (Est,L) elastance, intra-abdominal pressure (IAP), end-expiratory volume (EELV) at 0, 5, 10, 15 cm H2O positive (PEEP) 12 patients with ARDSp nine ARDSexp. At zero (ZEEP), Est,rs EELV were similar both groups of patients. The Est,L, however, was markedly higher...
We investigated the effects of body mass index (BMI) on functional residual capacity (FRC), respiratory mechanics (compliance and resistance), gas exchange, inspiratory mechanical work done per liter ventilation during general anesthesia.We used esophageal balloon technique, together with rapid airway occlusion constant flow, to partition system into its pulmonary chest wall components. FRC was measured by using helium dilution technique. studied 24 consecutive unselected patients...
We investigated the effects of body mass index (BMI) on functional residual capacity (FRC), respiratory mechanics (compliance and resistance), gas exchange, inspiratory mechanical work done per liter ventilation during general anesthesia.We used esophageal balloon technique, together with rapid airway occlusion constant flow, to partition system into its pulmonary chest wall components. FRC was measured by using helium dilution technique. studied 24 consecutive unselected patients...
Systemic hypotension during sepsis is thought to be due nitric oxide (NO) overproduction, but it may also acidosis. We evaluated in healthy rats the consequences of acid infusion on NO and blood pressure. Sprague-Dawley were anesthetized, ventilated with room air. The animals randomized into four groups. Group 1 (C, n = 10) received only normal saline at rates comparable other 2 (A1, hydrochloric 0.162 mmol first 15 30 min, followed by a continuous 0.058 mmol/h for 5 h. 3 (AG + A1, 6) was...
Vaccination against SARS-CoV-2 has been the main tool to contain pandemic. The rush development of 3 vaccines and their expedited approval have led inoculation millions patients around world, leading a containment disease. Despite continuous viral mutations identification weaker variants, severity infections mild, with many being either asymptomatic or recovering at home. Currently focus shifted from host organ damage related infection potential side effects vaccine. Myocarditis reported as...
Background Postoperative ileus is a common complication of intraabdominal surgeries, including radical cystectomy with reported rates as high 32%. Perioperative fluid administration has been associated improvement in postoperative rates, but it difficult to generalize because earlier studies lacked standardized definitions and other relevant outcomes. The hypothesis was that targeted individualized perioperative management would improve patients receiving cystectomy. Methods This...
Intra-operative hypotension is a known predictor of adverse events and poor outcomes following major surgery. Hypotension often occurs on induction anaesthesia, typically attributed to hypovolaemia the haemodynamic effects anaesthetic agents. We assessed efficacy fluid optimisation for reducing incidence anaesthesia. This prospective trial enrolled 283 patients undergoing radical cystectomy randomly allocated them goal-directed therapy (n = 142) or standard 141). Goal-directed received based...
The coronavirus disease 2019 (COVID-19) is associated with a wide clinical spectrum of skin manifestations, including urticarial, vesicular, vasculitic and chilblain-like lesions. Recently, delayed reactions have been reported in 1% individuals following mRNA vaccination against SARS-CoV-2. exact pathophysiology the risk factors still remain unclear.6821 employees patients were vaccinated at our institutions between February June 2021. Every patient received two doses mRNA-1273 vaccine...
Background Postoperative atrial fibrillation may identify patients at risk of subsequent fibrillation, with its greater stroke. This study hypothesized that N-acetylcysteine mitigates inflammation and oxidative stress to reduce the incidence postoperative fibrillation. Methods In this double-blind, placebo-controlled trial, high scheduled undergo major thoracic surgery were randomized plus amiodarone or placebo amiodarone. On arrival postanesthesia care unit, intravenous bolus (50 mg/kg)...
Abstract Background COVID-19, the pandemic disease caused by infection with SARS-CoV-2, may take highly variable clinical courses, ranging from symptom-free and pauci-symptomatic to fatal disease. The goal of current study was assess association COVID-19 courses controlled patients’ adaptive immune responses without progression severe Human Leukocyte Antigen (HLA) genetics, AB0 blood group antigens, presence or absence near-loss-of-function delta 32 deletion mutant C–C chemokine receptor...
Abstract Background Surgery is the primary treatment for non-small cell lung cancer (NSCLC), but microscopic residual disease may be unavoidable. Preclinical studies have shown that volatile anesthetics might suppress host immunity and promote a pro-malignant environment supports proliferation, migration, angiogenesis, whereas propofol preserve cell-mediated inhibit tumor angiogenesis. However, clinical evidence propofol-based total intravenous anesthesia (TIVA) can reduce recurrence after...
Obesity is a worldwide health problem affecting 34% of the American population. As result, more patients requiring anesthesia for thoracic surgery will be overweight or obese. Changes in static and dynamic respiratory mechanics, upper airway anatomy, as well multiple preoperative comorbidities altered drug metabolism, characterize obese affect anesthetic plan at levels. During evaluation, should assessed to identify who risk difficult ventilation intubation, postoperative complications. The...
Protective lung ventilation (PLV) during one-lung (OLV) for thoracic surgery is frequently recommended to reduce pulmonary complications. However, limited outcome data exist on whether PLV use OLV associated with less clinically relevant morbidity after resection.Intraoperative were prospectively collected in 1080 patients undergoing resection OLV, intentional crystalloid restriction, and mechanical maintain inspiratory peak airway pressure <30 cm H2O. Other ventilator settings all aspects...
Objective To evaluate the effect of treatment with a combination nitric oxide synthase inhibitors and inhaled on systemic hypotension during sepsis. Design Prospective, randomized, controlled study anesthetized animals. Setting A cardiopulmonary research laboratory. Subjects Forty-seven male adult Sprague-Dawley rats. Interventions Animals were anesthetized, mechanically ventilated room air, randomized into six groups: a) control group (C, n = 6) received normal saline infusion; b)...
1. We investigated the effect of hyperbaric oxygenation (HBO2) pretreatment on production exhaled nitric oxide (ENO) and expression lung inducible synthase (iNOS) by Escherichia coli lipopolysaccharide (LPS)-induced shock in an experimental rat model. 2. Rats were randomized into four groups, anaesthetized, mechanically ventilated with room air infused normal saline (2 mL/h) through jugular vein for 5 h. Group 1 (NS) received only saline. 2 (HBO2-NS) was pretreated HBO2 at 2.8 absolute...