A5059175252- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- SARS-CoV-2 and COVID-19 Research
- Cancer Treatment and Pharmacology
- Glioma Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Advanced Radiotherapy Techniques
- Brain Metastases and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Head and Neck Cancer Studies
- Advanced Breast Cancer Therapies
- Global Cancer Incidence and Screening
- Breast Implant and Reconstruction
- Cancer survivorship and care
- Radiation Therapy and Dosimetry
- Long-Term Effects of COVID-19
- Viral Infections and Immunology Research
- BRCA gene mutations in cancer
- Head and Neck Surgical Oncology
- Tendon Structure and Treatment
- COVID-19 and healthcare impacts
- Infection Control and Ventilation
- Sarcoma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Pharmacovigilance and Adverse Drug Reactions
Heinrich Heine University Düsseldorf
2017-2025
Düsseldorf University Hospital
2017-2024
Klinik und Poliklinik für Strahlentherapie und Radioonkologie
2017-2020
TU Dresden
2018-2019
Klinik für Frauenheilkunde
2019
Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe
2019
Asklepios Klinikum Harburg
2019
Charité - Universitätsmedizin Berlin
2019
University Hospital Carl Gustav Carus
2018
Universitätsklinik für Frauenheilkunde und Geburtshilfe
2017
Surgical reconstruction after segmental mandibulectomy in patients with oral cancer commonly requires implantation of titanium plates, which cause metallic artifacts CT examinations detrimental for image quality. Therefore, the aim present study was to evaluate and quality polymer plate materials polyetheretherketone (PEEK), polyetherketoneketone (PEKK), polyphenylsulfone (PPSU), polyethylene (PE) mandible reconstruction.Five plates (titanium, PEEK, PEKK, PPSU, PE) were successively...
Vaccination against SARS-CoV-2 has been the main tool to contain pandemic. The rush development of 3 vaccines and their expedited approval have led inoculation millions patients around world, leading a containment disease. Despite continuous viral mutations identification weaker variants, severity infections mild, with many being either asymptomatic or recovering at home. Currently focus shifted from host organ damage related infection potential side effects vaccine. Myocarditis reported as...
Abstract Background Medulloblastoma is the most common malignant pediatric brain tumor, typically treated with normofractionated craniospinal irradiation (CSI) an additional boost over about 6 weeks in children older than 3 years. This study investigates sensitivity of medulloblastoma cell lines to different radiation fractionation schedules. While extensively studied adult tumors, these ratios remain unknown cases due rarity disease. Materials and methods Five distinct (ONS76, UW228-3,...
The polycystic ovary syndrome is a common endocrine disorder which influences outcome and potential risks involved with controlled ovarian stimulation for artificial reproductive techniques (ART). Concrete practical recommendations the dosage of gonadotropins, preferred protocol preventive methods to avoid hyperstimulation (OHSS) are lacking. We present retrospective data 235 individually calculated gonadotropin low-dose stimulations ART in single center from 2012 2014. Clinical parameter...
The coronavirus disease 2019 (COVID-19) is associated with a wide clinical spectrum of skin manifestations, including urticarial, vesicular, vasculitic and chilblain-like lesions. Recently, delayed reactions have been reported in 1% individuals following mRNA vaccination against SARS-CoV-2. exact pathophysiology the risk factors still remain unclear.6821 employees patients were vaccinated at our institutions between February June 2021. Every patient received two doses mRNA-1273 vaccine...
Abstract Background COVID-19, the pandemic disease caused by infection with SARS-CoV-2, may take highly variable clinical courses, ranging from symptom-free and pauci-symptomatic to fatal disease. The goal of current study was assess association COVID-19 courses controlled patients’ adaptive immune responses without progression severe Human Leukocyte Antigen (HLA) genetics, AB0 blood group antigens, presence or absence near-loss-of-function delta 32 deletion mutant C–C chemokine receptor...
Purpose/Objective: The standard treatment for localized low-risk breast cancer is breast-conserving surgery, followed by adjuvant radiotherapy and appropriate systemic therapy. As the majority of local recurrences occur at site primary tumor, numerous trials have investigated partial-breast irradiation (PBI) instead whole-breast (WBI) using a multitude techniques fractionation regimens. This meta-analysis addresses impact on disease-specific endpoints, such as regional control, well...
Neoadjuvant radiotherapy (naRT) in addition to neoadjuvant chemotherapy (naCT) has been used for locally advanced, inoperable breast cancer or allow conserving surgery (BCS). Retrospective analyses suggest that naRT + naCT might result an improvement pathological complete response (pCR rate and disease-free survival). pCR is a surrogate parameter improved event-free overall survival (OS) allows the adaption of post-neoadjuvant therapy regimens. However, it not clear whether achieved with...
Adjuvant radiotherapy after breast conserving surgery is the standard approach in early stage cancer. However, extent of tissue that has to be targeted with radiation not been determined yet. Traditionally, whole was covered by two opposing tangential beams. Several randomized trials have tested partial irradiation (PBI) compared (WBI) using different techniques. There evidence from PBI might result lower mortality rates WBI. We aimed reassess this question current data trials.We performed a...
Abstract Background In radical radiochemotherapy (RCT) of inoperable non-small-cell lung cancer (NSCLC) typical prognostic factors include T- and N-stage, while there are still conflicting data on the relevance gross tumor volume (GTV) particularly its changes during RCT. The NCT03055715 study Young DEGRO working group German Society Radiation Oncology (DEGRO) evaluated impact GTV Methods A total 21 university centers for radiation oncology from five different European countries (Germany,...
Background: Multiple randomized trials have established adjuvant endocrine therapy (ET) and whole breast irradiation (WBI) as the standard approach after breast-conserving surgery (BCS) in early-stage cancer. The omission of WBI has been studied multiple resulted reduced local control with maintained survival rates therefore adapted a treatment option selected patients several guidelines. Omitting ET instead might also be valuable both treatments distinctly different side effect profiles....
Isocitrate dehydrogenase (IDH)-wildtype glioblastomas are the most malignant glial tumours. Median survival is only 14-16 months after diagnosis, with patients aged ≥ 65 years reportedly showing worse outcome. This study aimed to further evaluate prognostic role of age in a homogenously treated patient cohort.The includes 132 IDH-wildtype glioblastoma between 2013 and 2017 open resection followed by radiotherapy concomitant maintenance temozolomide. Patients were dichotomized into...
Abstract Purpose COVID-19 infection has manifested as a major threat to both patients and healthcare providers around the world. Radiation oncology institutions (ROI) deliver component of cancer treatment, with protocols that might span over several weeks, result increasing susceptibility presenting more severe clinical course when compared general population. The aim this manuscript is investigate impact ROI performance on daily practice in high-risk during pandemic. Methods We addressed...