A5078286006- Immune Cell Function and Interaction
- Brain Metastases and Treatment
- Gastric Cancer Management and Outcomes
- Bladder and Urothelial Cancer Treatments
- Advanced Radiotherapy Techniques
- Lung Cancer Diagnosis and Treatment
- T-cell and B-cell Immunology
- Radiomics and Machine Learning in Medical Imaging
- Cytomegalovirus and herpesvirus research
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Lymphoma Diagnosis and Treatment
- Lung Cancer Research Studies
- Chronic Lymphocytic Leukemia Research
- Head and Neck Cancer Studies
- COVID-19 and healthcare impacts
- Esophageal Cancer Research and Treatment
- Glioma Diagnosis and Treatment
- Radiation Dose and Imaging
- Palliative Care and End-of-Life Issues
- Management of metastatic bone disease
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Cancer survivorship and care
- Groundwater flow and contamination studies
Innsbruck Medical University
2013-2024
Universität Innsbruck
2002-2024
Centre Hospitalier de Saint-Malo
2022
Hôpital Tenon
2021
Sorbonne Université
2021
Goethe University Frankfurt
2020
Austrian Academy of Sciences
2011-2012
Pforzheim University of Applied Sciences
2012
The life-long homeostasis of memory CD8(+) T cells as well persistent viral infections have been shown to facilitate the accumulation highly differentiated CD28(-) cells, a phenomenon that has associated with an impaired immune function in humans. However, molecular mechanisms regulating not yet elucidated. In this study, we demonstrate miR-23∼24∼27 cluster is up-regulated during post-thymic T-cell differentiation increased expression miR-24 decreased histone variant H2AX, protein plays key...
The immune system undergoes profound age-related changes, including a gradual increase in the production and circulation of proinflammatory cytokines. Despite known capacity fibroblasts to produce cytokines, little is so far about inflammatory response cellular stress such as viral and/or bacterial infection context aging. Therefore aim this study was analyze levels IL6 IL8 secretion supernatants human skin from young elderly persons. Cytokine chemokine analyzed before after vitro cells with...
of this study is to determine the temporal resolution therapy-induced pneumonitis, and assess promoting factors in adjuvant treated patients with unilateral mammacarcinoma. A total 100 post-surgery were recruited. The cohort was by 2 field radiotherapy (2FRT; breast chest wall, N = 75), 3 (3FRT; + supraclavicular lymphatic region, 8), or 4 (4FRT; parasternal 17). Ninety-one received various systemic treatments prior irradiation. Following an initial screening visit post-RT, two additional...
Abstract Background To permit timely mitigation of adverse effects on overall clinical outcome, it is essential to understand how the pandemic influences distress and health‐related quality life (HRQOL) in cancer patients during coronavirus disease 2019 (COVID‐19) pandemic. Methods In this cross‐sectional study, adult patients, without COVID‐19 symptoms, completed a 13‐item questionnaire about pandemic's impacts everyday‐life; associations with age, sex, or impaired HRQOL were then assessed...
The present study investigates the intrafractional accuracy of a frameless thermoplastic mask used for head immobilization during stereotactic radiotherapy. Non-invasive masks cannot completely prohibit movements. Previous studies attempted to estimate magnitude inaccuracy by means pre- and postfractional measurements only. However, this might not be sufficient accurately map also movements.Intrafractional deviation mask-fixed positions was measured in five patients total 94 fractions...
Cancer patients frequently suffer from physical and psychosocial impairments due to their disease its treatment. Psychooncology (PO) can help cope with stress resulting outpatient radiotherapy (RT) There are currently few data regarding patients' wishes for PO support. The aim of this study was investigate the number a wish PO, treatment paths, predictors among cancer at beginning RT.The results routine psychological screening (Hornheide instrument; cut-off ≥ 4) 944 between 2015 2017 were...
Metastatic progression of malignant tumors resistant to conventional therapeutic approaches is an ultimate challenge in clinical oncology. Despite the efforts basic and researchers, there still no effective treatment schedule prevent or combat metastatic spread tumors. This report presents recent findings that could help development targeted therapeutics directed against most aggressive treatment-resistant carcinoma cells. It was demonstrated HNSCC cell lines with acquired resistance...
Abstract Background In radical radiochemotherapy (RCT) of inoperable non-small-cell lung cancer (NSCLC) typical prognostic factors include T- and N-stage, while there are still conflicting data on the relevance gross tumor volume (GTV) particularly its changes during RCT. The NCT03055715 study Young DEGRO working group German Society Radiation Oncology (DEGRO) evaluated impact GTV Methods A total 21 university centers for radiation oncology from five different European countries (Germany,...
Abstract Background Cerebral palsy (CP) is the most common motor impairment in childhood and often accompanied by a broad spectrum of comorbidities. Data are sparse concerning visual (VI) functional classification among CP children. Objective The objective this study was to analyze prevalence VI children with investigate possible association between Gross Motor Function Classification System (GMFCS) Bimanual Fine (BFMF). Methods In hospital-based study, records 200 aged 2 17 years were...
Despite a comparatively favorable prognosis relative to other malignancies, breast cancer continues significantly impact women’s health globally, partly due its high incidence rate. A critical factor in treatment failure is radiation resistance – the capacity of tumor cells withstand doses ionizing radiation. Advancements understanding cellular and molecular mechanisms underlying radioresistance, coupled with enhanced characterization radioresistant cell clones, are paving way for...
This study aims to evaluate the clinical outcome of stereotactic radiosurgery as sole treatment for brain metastases and assess prognostic factors influencing survival. A total 108 consecutive patients with 213 were retrospectively analyzed. Treatment was determined close-meshed MRI follow-up. Various assessed, several indices compared regarding their reliability estimate overall Median survival 15 months; one-year 50.5%. Both one- two-year local controls 90.9%. The rate new after SRS 49.1%....
Abstract Overall survival (OS) of patients with brain metastases treated hypofractionated (HFSRT) or single-fraction (SRS) radiosurgery depends on several prognostic factors. The aim this study was to investigate the potential sex as an independent predictor OS and evaluate predictive accuracy common scores. Retrospective analysis 281 consecutive receiving performed. Kaplan–Meier curves Cox proportional hazards models were used compare between SRS HFSRT by sex, before after propensity-score...
Abstract Background Contrast-enhanced high-resolution computed tomography (contrast-CT) is a standard imaging modality following primary concurrent radiochemotherapy (RCT) for response evaluation in patients with head and neck squamous cell carcinoma (HNSCC). We investigated the additional benefit of Fluorine-18-fluorodeoxyglucose ([18F]FDG) - positron emission (PET-CT), if complete (CR) based on contrast-CT was considered unsafe by interdisciplinary tumor board (ITB). Methods In...
Abstract The water residence time of the high mountain seepage lake Gossenköllesee (2413 m, Tyrol, Austria) was determined by measuring flushing rate a tracer substance. During holomixis in July 1997, when circulation occurred throughout entire column, dilute lithium chloride solution injected into causing concentration to rise from background value 0·06 3·1 μg L −1 . derived exponential decline mass between and October holomixis. about 2 months, i.e. volume exchanged twice two periods...
Summary Neoadjuvant chemoradiotherapy is a well-established standard treatment for locally advanced rectal cancer and has led to remarkable improvement in local control. However, distant recurrences still pose notable threat failure, albeit increasingly rare, can lead unfavorable clinical situations. In this short review, we discuss three promising new strategies improve treatment: total neoadjuvant therapy, course radiotherapy, immune checkpoint inhibitors.
Abstract Background: Overall survival (OS) of patients with brain metastases treated hypofractionated (HFSRT) or single-fraction (SRS) radiosurgery depends on several prognostic factors. The aim this study was to investigate the potential sex as an independent predictor OS and evaluate predictive accuracy common scores. Methods: Retrospective analysis 281 consecutive receiving performed. Kaplan-Meier curves Cox proportional hazards models were used compare between SRS HFSRT by sex, before...
Aims: Cerebral Palsy (CP) is the most common motor impairment in childhood and often accompanied by a broad spectrum of comorbidities.
Treatment of muscle-invasive bladder cancer (MIBC) remains challenging, especially for elderly and/or comorbid patients. Patients who are unfit or refuse surgery should receive bladder-preserving multimodality treatment (BPMT), consisting transurethral resection the tumor (TURB) followed by combined chemoradiotherapy (CRT). We aimed to investigate effectiveness vinorelbine, a chemotherapeutic agent not routinely used MIBC, in patients referred CRT standard chemotherapy and would thus rely...