A5054199690- Mesenchymal stem cell research
- Proteoglycans and glycosaminoglycans research
- Tissue Engineering and Regenerative Medicine
- Genetics, Aging, and Longevity in Model Organisms
- MicroRNA in disease regulation
- Glycosylation and Glycoproteins Research
- Electrospun Nanofibers in Biomedical Applications
- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- 3D Printing in Biomedical Research
- Telomeres, Telomerase, and Senescence
- Pluripotent Stem Cells Research
- Fibroblast Growth Factor Research
- Connective tissue disorders research
- Bone Tissue Engineering Materials
- Diamond and Carbon-based Materials Research
- Microfluidic and Bio-sensing Technologies
- Bioinformatics and Genomic Networks
- Genomics and Chromatin Dynamics
- Oral health in cancer treatment
- Hematopoietic Stem Cell Transplantation
- Retinoids in leukemia and cellular processes
- Carbohydrate Chemistry and Synthesis
- Healthcare and Venom Research
University of Salzburg
1997-2024
Universität Innsbruck
2015-2018
Austrian Academy of Sciences
2004-2013
Matrix Research (United States)
2010
Ludwig Boltzmann Institute for Age Research
2007
University Hospital Innsbruck
2007
Institute on Aging
2006
National Institutes of Health
2002
Uppsala University
2000
Sidney Kimmel Cancer Center
2000
Mesenchymal stem cells (MSC) are capable of differentiating into bone, fat, cartilage, tendon and other organ progenitor cells. Despite the abundance MSC within organism, little is known about their in vivo properties or corresponding niches. We therefore isolated from spongy (cancellous) bone biopsies healthy adults. When compared with surrounding marrow, a fourfold higher number colony-forming units was found tight meshwork trabecular surface. At these sites, oxygen concentrations range 1%...
Aging is a multifactorial process where deterioration of body functions driven by stochastic damage while counteracted distinct genetically encoded repair systems. To better understand the genetic component aging, many studies have addressed gene and protein expression profiles various aging model systems engaging different organisms from yeast to human. The recently identified small non-coding miRNAs are potent post-transcriptional regulators that can modify up several hundred target genes...
Using Expressed Sequence Tags (ESTs) deposited in the data banks, a cDNA has been assembled that encodes protein related to hyaluronidases from bee venom and mammalian sperm. Expression of this yielded polypeptide termed HYAL2, which is located lysosomes. The HYAL2 was shown have hyaluronidase activity below pH 4. However, it only hydrolyzed hyaluronan high molecular mass umbilical cord, rooster comb, Streptococcus strain. reaction product polysaccharide about 20 kDa, further small...
Mesenchymal stromal cells (MSC) are currently tested in a large number of clinical trials and raise high hope regenerative medicine. These have to be expanded vitro before transplantation several studies demonstrated that long-term culture evokes continuous changes MSC: proliferation rate decays, the cell size increases, differentiation potential is affected, chromosomal instabilities may arise molecular acquired. Long-term preparations might also therapeutic consequences, although this has...
Abstract Recently, a key role in memory T cell homing and survival has been attributed to the bone marrow (BM) mice. In human BM, repertoire, function, niches of CD4+ CD8+ cells have not yet elucidated. this study, we demonstrate that effector accumulate BM are heightened activation state as revealed by CD69 expression. BM-resident produce more IFN-γ frequently polyfunctional. Immunofluorescence analysis immediate vicinity IL-15–producing cells, suggesting close interaction between these two...
Mesenchymal stem cells (MSC) are currently strong candidates for cell-based therapies. They well known their differentiation potential and immunoregulatory properties have been proven to be potentially effective in the treatment of a large variety diseases, including neurodegenerative disorders. Currently there is no that provides consistent long-term benefits patients with multiple system atrophy (MSA), fatal late onset α-synucleinopathy. Principally neuroprotective or regenerative...
ABSTRACT Recently, the BM has been shown to play a key role in regulating survival and function of memory T cells. However, impact aging on these processes not yet studied. We demonstrate that number CD4+ CD8+ cells is maintained during aging. composition cell pool aged altered with decline naïve an increase TEM In contrast PB, highly activated CD8+CD28– population, which lacks late differentiation marker CD57, accumulates elderly persons. IL-6 IL-15, are both increased BM, efficiently...
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Bv8, a protein from skin secretions of Bombina variegata , reacts with receptors present in mammalian brain and intestine (Mollay et al. (1999) Eur. J. Pharmacol. 374, 189–196). As deduced cloned cDNAs, the murine human Bv8 homologues have identical amino‐terminal sequences also contain 10 cysteines. From mouse testes, two forms mRNA been characterized, which one contains an additional exon codes for 21 mostly basic amino acids. The gene is most active mid‐late pachytene spermatocytes. In...
Abstract We have recently described an IL-2/IL-4-producing CD8+CD25+ nonregulatory memory T cell population that occurs in a subgroup of healthy elderly persons who characteristically still good humoral response after vaccination. The present study addresses this specific subset and investigates its origin, clonal composition, Ag specificity, replicative history. demonstrate cells frequently exhibit CD4+CD8+ double-positive phenotype. expression the CD8 αβ molecule occurrence signal-joint...
Abstract Previous studies have identified the mammalian homologue of Bv8 (mBv8), a small protein originally isolated from skin secretions frog, Bombina variegata . In situ hybridization showed that mBv8 RNA was widely expressed in rodent CNS, with high levels being detected layer II cerebral cortex, limbic regions, cerebellar Purkinje cells, and dorsal ventral horns spinal cord. A similar pattern distribution found by examining presence immunocytochemistry. Addition frog to cultured granule...