A5076937125- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Brain Metastases and Treatment
- Advanced Radiotherapy Techniques
- Advances in Oncology and Radiotherapy
- Meningioma and schwannoma management
- Lung Cancer Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Nanoparticle-Based Drug Delivery
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- Antibiotics Pharmacokinetics and Efficacy
- Health, Medicine and Society
- Acute Kidney Injury Research
- Epigenetics and DNA Methylation
- Head and Neck Cancer Studies
- Economic and Financial Impacts of Cancer
- Radiation Therapy and Dosimetry
- Cancer Genomics and Diagnostics
- Circular RNAs in diseases
- Nanoplatforms for cancer theranostics
- Random Matrices and Applications
- Privacy-Preserving Technologies in Data
Ludwig-Maximilians-Universität München
2016-2025
LMU Klinikum
2016-2025
University Hospital Regensburg
2023-2025
Heidelberg University
2016-2025
German Cancer Research Center
2016-2025
University Hospital Heidelberg
2020-2025
University of Regensburg
2019-2024
Deutschen Konsortium für Translationale Krebsforschung
2017-2024
University Children's Hospital Tübingen
2024
Colorado State University
2024
Background and PurposeThere is no randomized evidence comparing whole-brain radiotherapy (WBRT) stereotactic radiosurgery (SRS) in the treatment of multiple brain metastases. This prospective nonrandomized controlled single arm trial attempts to reduce gap until results are available.Material MethodsWe included patients with 4-10 metastases ECOG performance status ≤2 from all histologies except small-cell lung cancer, germ cell tumors, lymphoma. The retrospective WBRT-cohort was selected 2:1...
In this dosimetric study, a dedicated planning tool for single isocenter stereotactic radiosurgery multiple brain metastases using dynamic conformal arc therapy (DCAT) was compared to standard volumetric modulated (VMAT). Twenty patients with total of 66 lesions who were treated the DCAT included in study. Single fraction doses 15–20 Gy prescribed each lesion. Patients re-planned non-coplanar VMAT. Number monitor units as well V4Gy, V5Gy and V8Gy extracted every plan. Using density-based...
Abstract Glioblastoma is the most aggressive primary brain tumor characterized by a dismal prognosis and profound therapy resistance that evident for mesenchymal molecular subtype of glioblastoma. Targeting vascular endothelial growth factor (VEGF)‐A monoclonal antibody bevacizumab, despite failing to improve survival in randomized trials, yields relevant benefits glioblastoma patients such as reduction radionecrosis, an adverse event associated with radiotherapy. This demands continued...
A considerable number of patients with chronic inflammatory bowel diseases (IBD) are required to manage extensive polypharmaceutical regimes, which significantly elevates the risk drug–drug interactions. Also, disease’s impact often leads consumption additional self-medication by such as naturopathic remedies alleviate disease-induced suffering and nutritional supplements compensate for malabsorption syndromes inherent condition. There is a well-established consensus that polymedication...
Background: Acute-on-chronic liver failure (ACLF) is a severe, rapidly progressing syndrome in patients with cirrhosis, often triggered by bacterial infections. Piperacillin/Tazobactam key antibiotic this setting, and therapeutic drug monitoring (TDM) helps optimize its dosing. This study evaluates the impact of an interprofessional TDM strategy for ACLF ICU. Methods: retrospective ICU evaluated approach optimizing dosing critically ill patients. The team, consisting physicians, clinical...
Abstract The heterogeneity of high‐grade glioma recurrences remains an ongoing challenge for the interdisciplinary neurooncology team. Response to re‐irradiation (re‐ RT ) is heterogeneous, and survival data depend on prognostic factors such as tumor volume, primary histology, age, possibility reresection, or time between diagnosis initial re‐ . In present pooled analysis, we gathered from radiooncology centers DKTK Consortium used it validate established score by Combs et al. its...
Poor target cell specificity is currently a major shortcoming of nanoparticles (NPs) used for biomedical applications. It causes significant material loss to off-target sites and poor availability at the intended delivery site. To overcome this limitation, we designed particles that identify cells in virus-like manner. As blueprint, chose mechanism typical influenza A virus which ectoenzymatic hemagglutinin activation by mandatory prerequisite binding secondary structure finally confirms...
Abstract Poor drug availability in the tissue of interest is a frequent cause therapy failure. While nanotechnology has developed plethora nanocarriers for transport, their ability to unequivocally identify cells remains moderate. Viruses are ideal nanosized carriers as they able address embedded nucleic acids with high specificity host cells. Here, it reported that particles endowed virus‐like by three consecutive checks have superior recognize mesangial (MCs) vivo compared conventional...
Modern, personalized treatment concepts in oncology require an interdisciplinary and multiprofessional collaboration. In addition to its relevance patient care, collaboration is also becoming increasingly important clinical research as well medical education resident training oncology.Between November 2021 March 2022, online survey was conducted among German early career groups, represented by Young Oncologists United (YOU). The aim identify the status need for interdisciplinarity at clinic,...
The 18-kDa translocator protein (TSPO) is gaining recognition as a relevant target in glioblastoma imaging. However, data on the potential prognostic value of TSPO PET imaging are lacking. Therefore, we investigated association results with survival outcome homogeneous cohort patients. Methods: Patients were included who had newly diagnosed, histologically confirmed isocitrate dehydrogenase (IDH)-wild-type available before either normofractionated radiotherapy combined temozolomide or...
Abstract Purpose Medical students’ knowledge of radiation oncology (RO) is increasing importance with a rising prevalence malignancies. However, RO teaching in medical schools heterogeneous and has not been analyzed at federal level yet. Therefore, the following survey aims to provide national overview Germany. Methods A questionnaire containing multiple-choice free-text questions covering extent topics was sent departments all university hospitals Germany answered by heads department/main...
Pseudoprogression (PsP) or radiation necrosis (RN) may frequently occur after cranial radiotherapy and show a similar imaging pattern compared with progressive disease (PD). We aimed to evaluate the diagnostic accuracy of magnetic resonance imaging-based contrast clearance analysis (CCA) in this clinical setting.Patients equivocal findings were consecutively included into monocentric prospective study. CCA was carried out by software-based automated subtraction features late versus early...