A5037412930- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Alzheimer's disease research and treatments
- Glioma Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Radiomics and Machine Learning in Medical Imaging
- Neuroendocrine Tumor Research Advances
- Dementia and Cognitive Impairment Research
- Lung Cancer Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroblastoma Research and Treatments
- Advanced MRI Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Prostate Cancer Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Vestibular and auditory disorders
- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Thyroid Cancer Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Meningioma and schwannoma management
- Cancer, Hypoxia, and Metabolism
- S100 Proteins and Annexins
Ludwig-Maximilians-Universität München
2016-2025
LMU Klinikum
2016-2025
Munich Cluster for Systems Neurology
2015-2024
German Cancer Research Center
2017-2024
Deutschen Konsortium für Translationale Krebsforschung
2017-2024
Heidelberg University
2014-2024
German Center for Neurodegenerative Diseases
2023-2024
Klinik und Poliklinik für Nuklearmedizin
2013-2023
European Neuroendocrine Tumor Society
2019-2023
Imperial College London
2020-2023
<sup>177</sup>Lu-labeled PSMA-617 is a promising new therapeutic agent for radioligand therapy (RLT) of patients with metastatic castration-resistant prostate cancer (mCRPC). Initiated by the German Society Nuclear Medicine, retrospective multicenter data analysis was started in 2015 to evaluate efficacy and safety <sup>177</sup>Lu-PSMA-617 large cohort patients. <b>Methods:</b> One hundred forty-five (median age, 73 y; range, 43–88 y) mCRPC were treated 12 centers between February 2014 July...
The vestibular system--a sensor of head accelerations--cannot detect self-motion at constant velocity and thus requires supplementary visual information. perception during movement is completely dependent on visually induced vection. This can be linear vection or circular (CV). CV by large-field motion stimulation which the stationary subject perceives moving surroundings as being stable himself moved. To determine unknown cortical visual-vestibular interaction CV, we conducted a PET...
Brain imaging with positron emission tomography has identified some of the principal cerebral structures a central network activated by pain. To discover whether different cortical and subcortical areas process components multidimensional nature pain, we performed regression analysis between noxious heat-related regional blood flow increases experimental pain parameters reflecting detection encoding intensity, as well unpleasantness. The results our activation study indicate that functions...
Our objective was to evaluate the association of arterial <sup>18</sup>F-FDG uptake and calcifications in large arteries as detected by PET/CT with subsequent occurrence vascular events otherwise asymptomatic cancer patients. <b>Methods:</b> Clinical follow-up information obtained for 932 patients examined whole-body (median time, 29 mo). Among this cohort, 279 had died from their oncologic disease. In 15 (1.6%), a event, defined ischemic stroke, myocardial infarction, or revascularization,...
Recent studies show that nasal high flow (NHF) therapy can support ventilation in patients with acute or chronic respiratory disorders. Clearance of dead space has been suggested as being the key mechanism NHF therapy. The hypothesis this study was a dose-dependent manner clear upper airways from expired air and decrease rebreathing. randomized crossover involved 10 volunteers using scintigraphy 81mKrypton (81mKr) gas during breath-holding maneuver closed mouth 3 nasally breathing...
// Wolfgang P. Fendler 1,2 , Svenja Reinhardt 1 Harun Ilhan Andreas Delker Guido Böning Franz J. Gildehaus Christian Stief 3,4 Peter Bartenstein 1,4 Gratzke Sebastian Lehner and Axel Rominger Department of Nuclear Medicine, Ludwig-Maximilians-University Munich, Germany 2 Molecular Medical Pharmacology, David Geffen School Medicine at UCLA, Los Angeles, CA, USA 3 Urology, 4 Comprehensive Cancer Center, Correspondence to: Fendler, email: Keywords : mCRPC; PET; prostate cancer; PSMA;...
Progressive supranuclear palsy (PSP) is a 4-repeat tauopathy. Region-specific tau aggregates establish the neuropathologic diagnosis of definite PSP post mortem. Future interventional trials against in would strongly benefit from biomarkers that support diagnosis.To investigate potential novel radiotracer 18F-PI-2620 as biomarker patients with clinically diagnosed PSP.In this cross-sectional study, participants underwent dynamic positron emission tomography (PET) 0 to 60 minutes after...
We evaluated the accuracy of PET/CT with <sup>68</sup>Ga-PSMA-HBED-CC—a <sup>68</sup>Ga-conjugated ligand human prostate-specific membrane antigen (PSMA)—to localize cancer in prostate and surrounding tissue at initial diagnosis. <b>Methods:</b> Twenty-one patients biopsy-proven underwent <sup>68</sup>Ga-PSMA-HBED-CC (<sup>68</sup>Ga-PSMA) a median 4 d (range, 0–47 d) before radical prostatectomy. Based on 6-segment model, Gleason score proportion tumor within each segment (segmental burden,...
2-Deoxy-2-[18F]fluoro-d-glucose positron emission tomography (FDG-PET) is widely used to study cerebral glucose metabolism. Here, we investigated whether the FDG-PET signal directly influenced by microglial uptake in mouse models and patients with neurodegenerative diseases. Using a recently developed approach for cell sorting after FDG injection, found that, at cellular resolution, microglia displayed higher than neurons astrocytes. Alterations were responsible both decrease Trem2-deficient...
Abstract Tau pathology is the main driver of neuronal dysfunction in 4-repeat tauopathies, including cortico-basal degeneration and progressive supranuclear palsy. assumed to spread prion-like across connected neurons, but mechanisms tau propagation are largely elusive characterized not only by also astroglial oligodendroglial accumulation. Here, we assess whether connectivity associated with 4R-tau deposition patterns combining resting-state fMRI connectomics both 2 nd generation 18...
<h3>Background</h3> Long-term high-frequency stimulation of the subthalamic nucleus (STN) improves akinesia in Parkinson disease. The neural correlates STN are not well understood. Positron emission tomography can be applied to vivo study mechanisms deep brain stimulation. <h3>Objective</h3> To changes regional cerebral blood flow as an index synaptic activity patients with disease effective on and off during rest movement. <h3>Methods</h3> Eight who had electrodes implanted underwent 12...
In patients with arrhythmogenic right ventricular cardiomyopathy (ARVC), the frequent provocation of tachycardia during exercise, sensitivity toward catecholamines, and response antiarrhythmic drug regimen antiadrenergic properties suggest an involvement sympathetic nervous system in arrhythmogenesis.To analyze presence, extent, location impaired myocardial innervation ARVC, 123I-meta-iodobenzylguanidine (123I-MIBG) scintigraphy was performed 48 ARVC. For comparison, 9 idiopathic a control...
SummaryPrompted by the observation of decreased glucose metabolism in striate and extrastriate visual cortex a patient with opsoclonus, we studied influence involuntary eye movements on activity. Repeated measurements cerebral blood flow (CBF) PET were performed 12 healthy volunteers using H215 O-bolus technique after ear canal irrigation, either ice cold or warm (44°C) water subject's eyes closed. In addition to increases areas involved central vestibular processing, statistical subtraction...