A5043734956- Advanced Radiotherapy Techniques
- Lymphoma Diagnosis and Treatment
- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- Radiopharmaceutical Chemistry and Applications
- Head and Neck Surgical Oncology
- Medical Imaging Techniques and Applications
- Radiation Dose and Imaging
- Radiation Therapy and Dosimetry
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Endometrial and Cervical Cancer Treatments
- Advanced X-ray and CT Imaging
- Polymer Surface Interaction Studies
- Gastric Cancer Management and Outcomes
- Microplastics and Plastic Pollution
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Breast Cancer Treatment Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Advances in Oncology and Radiotherapy
- Blood properties and coagulation
- CNS Lymphoma Diagnosis and Treatment
University Hospital Münster
2020-2025
Friedrich Schiller University Jena
2016
Schott (Germany)
2016
Background/Objectives: The actual daily dose distribution during image-guided radiotherapy (IGRT) for prostate cancer (PCa) deviates from the planned due to positional and volumetric changes in patient’s body organs at risk (OAR). This study investigates difference between delivered dose, by calculating bladder rectum each fraction. impact of OAR volumes on correlation with treatment-related toxicities will be evaluated. Methods: A cone-beam computed tomography (CBCT) based calculation was...
Radiation therapy (RT) is an integral part of treatment concepts for early-stage Hodgkin lymphoma. This analysis reports on RT quality in the recent HD16 and 17 trials German Study Group (GHSG).All plans involved-node radiation (INRT) HD were requested analysis, along with 100 50 involved-field (IFRT) 16 17, respectively. A structured assessment regarding field design protocol adherence was performed by reference oncology panel GHSG.Overall, (HD 16) 176 17) patients eligible analysis. In 16,...
Introduction The German Hodgkin Study Group (GHSG) HD17 trial established the omission of radiotherapy (RT) for patients with early-stage unfavorable lymphoma being PET-negative after 2 cycles BEACOPP escalated plus ABVD. This patient group reveals heterogeneity in characteristics and disease extent which prompted us to perform a decisive dosimetric analysis according GHSG risk factors. may help tailor RT individually balancing risks benefits. Methods For quality assurance, RT-plans were...
Nanostructured surfaces have the potential to influence assembly as well orientation of adsorbed proteins and may, thus, strongly biomaterials' performance. For class polymeric (bio)materials a reproducible well-characterized nanostructure is ordered chain folded surface polyethylene single crystal (PE-SC). We tested hypothesis that trinodal-rod-shaped protein human plasma fibrinogen (HPF) adsorbs on (001) PE-SCs along specific crystallographic directions. The PE-SC samples were prepared by...
Abstract Purpose This study aims to evaluate the best possible practice using hybrid volumetric modulated arc therapy (H-VMAT) for hypofractionated radiation of breast cancer. Different combinations H‑VMAT—a combination three-dimensional radiotherapy (3D-CRT) and VMAT—were analyzed regarding planning target volume (PTV), dose coverage, exposure organs at risk (OAR). Methods Planning computed tomography scans were acquired in deep-inspiration breath-hold. A total 520 treatment plans...
Purpose: Hodgkin lymphoma is a hematologic malignancy with excellent outcomes even in advanced stages. Consequently, the importance of treatment-associated toxicity increases. However, exact estimation individualized rates difficult due to different disease extents, treatment strategies and techniques. The following analysis aims at pre-treatment relevant mediastinal toxicities. Methods: Normal tissue complication probability calculations were used evaluate for heart, lungs female breast...
Table 1: Size of the planning targe volume (PTV) and dose exposure to organs at risks in comparison between involved-field (IFRT) radiotherapy involved-node (INRT). Gy: Gray Question: The HD17 trial German Hodgkin Study Group evaluated value consolidative (IN)RT for patients with PET-positivity after chemotherapy enabled a INRT (IF)RT [1]. present work analyzes risk (OAR) performed RT. Methods/Material: For dosimetric evaluation, all INRT-plans HD 17 were requested compared random selection...
This biophysical study aimed to determine fitting parameters for the Lyman-Kutcher-Burman (LKB) dose-response model normal tissue complication probability (NTCP) calculations of acute side effects and investigate impact reduced radiation doses on their occurrence in supradiaphragmatic non-Hodgkin lymphoma (NHL) irradiation. A cohort 114 patients with NHL cervicothoracic region, treated between 2015 2021 at University Hospitals Münster, Hamburg, Essen, involved site therapy (ISRT), were...
Abstract Purpose This article reports on the long-term impact of radiotherapy adapted to stage, histology, and previous resection in a large cohort patients with intestinal lymphoma (iL) treated definitive or adjuvant curative-intent radiation therapy (RT) ± chemotherapy (CHOP, MCP, COP). Patients Methods In two consecutive prospective study designs, 134 indolent (stage IE–IIE) aggressive IE–IVE) iL were referred 61 radiotherapeutic institutions between 1992 2003. received extended field...
This work aims to investigate whether virtual non-contrast (VNC) dual-energy CT(DECT) of contrasted lung tumours can be used as an alternative for true (TNC) images in radiotherapy. Two DECT techniques and a TNC CT were compared influences on gross tumour volume (GTV) number from motion artefacts three-dimensional printed models (LTM) amotion phantom examined.Two spherical LTMs (diameter 3.0 cm) with different inner shapes created printer. The contained water or iodine (concentration 5 mg...
Background: Definitive radiochemotherapy is the treatment of choice for locally advanced nasopharyngeal carcinoma. Due to vicinity nasopharynx inner ear and use ototoxic platinum-based chemotherapy, there a risk irreversible damage auditory system. To avoid or minimize these critical side effects, radiation exposure each must be balanced between target volume coverage toxicity. However, normal tissue complication probability (NTCP) models validated by clinical data are rare. Patients...
Head and neck squamous cell carcinoma (HNSCC) is characterized by high relapse rates low survival in comparison to other malignancies.Fifty-two patients suffering from recurrent HNSCC were compared, analyzing the impact of different regimes, including surgery, radiotherapy (RT), chemotherapy immunotherapy on progression-free (PFS), overall (OS), locoregional control (LRC), adverse events.The standard RT technique was intensity-modulated (IMRT) all patients. In multivariate analysis, higher...
Question: The HD 16 trial of the German Hodgkin Study Group (GHSG) investigated use consolidative radiotherapy (RT) after 2 cycles ABVD chemotherapy for early-stage lymphoma (HL) and could demonstrate superiority a combined modality approach [1]. present work aims at analyzing quality involved-field RT used in this study. Methods/Material: For assessment, 100 randomly chosen plans from were requested analyzed. was assessed by experts radiation therapy panel GHSG using initial (staging)...
Question: The use of radiotherapy (RT) for intermediate-stage Hodgkin lymphoma is discussed vividly. HD17 trial the German Study Group (GHSG) evaluated value consolidative involved-node (IN)RT patients with PET-positivity after chemotherapy and enabled a comparison between INRT involved-field (IF)RT [1]. present work analyzes quality performed RT. Methods/Material: For assessment, all INRT-plans in HD 17 were requested compared to random selection IFRT-cases standard arm. RT was assessed by...
Primary lymphoma of the central nervous system (PCNSL) encompasses a variety subtypes, with majority being diffuse large B-cell lymphomas, which require aggressive systemic treatment. In contrast, low-grade lymphomas are reported infrequently and mostly limited to dural manifestations. Very rarely, parenchymal PCNSL is diagnosed, cases documented in literature show wide treatment approaches. We screened all treated at our department (a tertiary hematooncology neurooncology center) last 15...