A5003204399- Sinusitis and nasal conditions
- Asthma and respiratory diseases
- Head and Neck Cancer Studies
- Allergic Rhinitis and Sensitization
- Nasal Surgery and Airway Studies
- Head and Neck Surgical Oncology
- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Salivary Gland Tumors Diagnosis and Treatment
- Vestibular and auditory disorders
- Respiratory and Cough-Related Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immune Response and Inflammation
- Otitis Media and Relapsing Polychondritis
- Otolaryngology and Infectious Diseases
- Pediatric health and respiratory diseases
- Olfactory and Sensory Function Studies
- Cervical Cancer and HPV Research
- Cancer Diagnosis and Treatment
- Medical Practices and Rehabilitation
- Oral microbiology and periodontitis research
- Ear Surgery and Otitis Media
- Infectious Diseases and Mycology
- Ear and Head Tumors
- Obstructive Sleep Apnea Research
University Hospital Münster
2016-2025
Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde
2014-2025
University of Münster
2013-2024
Klinik für Schlafmedizin
2012-2024
Klinik und Poliklinik für Psychosomatik und Psychotherapie
2019-2022
Universitäts-HNO-Klinik Heidelberg
1995-2022
Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde
2003-2018
Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde
2007
Universitätsmedizin Greifswald
2002
Heinrich Heine University Düsseldorf
1995-1998
The complex anatomy of the human nose might offer distinct microbial niches. Microbiota composition may affect inflammatory diseases and Staphylococcus aureus carriage. Considering different nasal cavity locations, colonization was analysed across individuals exhibiting chronic (n = 18) those without local inflammation signs 16). Samples were collected systematically during surgery examined by an extensive culture-based approach and, for a subset, 16S rRNA gene community profiling....
Tinnitus is a result of hyper-activity/hyper-synchrony auditory neurons coding the tinnitus frequency, which has developed due to synchronous mass activity owing lack inhibition. We assume that removal exactly these frequencies from complex stimulus will cause brain reorganize around tonotopic regions frequency through inhibition-induced plasticity. Based on this assumption, novel treatment for tonal tinnitus--tailor-made notched music training (TMNMT)--has been introduced and was tested in...
To cite this article: Sachse F, Becker K, von Eiff C, Metze D, Rudack C. Staphylococcus aureus invades the epithelium in nasal polyposis and induces IL‐6 epithelial cells vitro . Allergy 2010; 65 : 1430–1437. Abstract Background: has been associated with chronic rhinosinusitis polyps (CRSwNP) pathogenesis but its role is still controversially discussed. Here, we demonstrate S. detection mucosa of CRSwNP. In addition, intracellular residency polyp (NPECs) capability to induce TH‐2 cytokines...
Summary Low density lipoprotein (LDL) and fibrinogen apheresis was recently reported to be an effective therapy in sudden hearing loss (SHL). In this study, we investigated whether and/or plasma concentrations, related gene polymorphisms other cardiovascular risk factors are also for SHL. Total cholesterol, HDL LDL cholesterol levels, two functionally relevant were determined 142 consecutive patients 84 age- sex-matched control subjects of the same ethnic background, using routine laboratory...
Recurrent respiratory papillomatosis (RRP) is a primary benign disease, which characterized by papillomatous growth in the tract. Malignant transformation occurs only 3‑5% of cases, however, local papillomas interpreted as clinically malignant markedly higher proportion patients. Local surgical or endoscopic interventional debulking excision currently commonly selected treatment method and antiviral therapy potential adjuvant approach. However, long‑term management RRP patients, who require...
BackgroundThe German multicenter randomized phase II larynx organ preservation (LOP) trial DeLOS-II was carried out to prove the hypothesis that cetuximab (E) added induction chemotherapy (IC) and radiotherapy improves laryngectomy-free survival (LFS; with preserved larynx) in locally advanced laryngeal/hypopharyngeal cancer (LHSCC).Patients methodsTreatment-naïve patients stage III/IV LHSCC amenable total laryngectomy (TL) were three cycles IC TPF [docetaxel (T) cisplatin (P) 75 mg/m2/day...
Cytokines are potent biologic factors involved in the regulation of inflammation, immune defense, and wound healing. Recently, growing interest has developed role cytokines chronic sinusitis nasal polyposis. In present study, we investigated cytokine profile different types rhinosinusitis order to evaluate whether a specific form is associated with expression certain profile. Sinus mucosa from patients acute (n = 10), 7), antrochoanal polyp polyps 8) controls turbinate 7) were sampled. The...
Modalities of surgical treatment early glottic carcinoma include transoral laser microresection and external partial surgery.This is a retrospective analysis 119 carcinomas treated by surgery (57 pT1a, 1 pT1b, 10 pT2) or (46 4 with special regard to initial anterior commissure involvement.Local recurrence in was 12%. Three- 5-year local control 86%. Local 16%. 88% 70%, respectively. No significant correlation found between approach. An all tumor revealed that involvement significantly...
The central auditory system has a crucial role in tinnitus generation and maintenance. Curative treatments for do not yet exist. However, recent attempts the therapeutic application of both acoustic stimulation/training procedures electric/magnetic brain stimulation techniques have yielded promising results. Here, first time we combined tailor-made notched music training (TMNMT) with transcranial direct current (tDCS) an effort to modulate TMNMT efficacy treatment 32 patients tonal without...
Electrophysiologic facial nerve monitoring is becoming an established intraoperative aid to assist the surgeon in trunk or branch location and dissection. Limited studies have addressed postoperative outcomes of parotid surgery with without monitoring.To examine influence on function procedure duration surgery.An 8-year retrospective review parotidectomies performed at Department Otorhinolaryngology-Head Neck Surgery, University Münster. The study analyzed 120 patients undergoing...
Abstract Background. Human papillomavirus (HPV) is a basic risk factor for head and neck squamous cell carcinoma (HNSCC). Little knowledge exists about the impact of HPV on clinical diagnostic therapy patients with HNSCC. Methods. We evaluated evidence HPV16 in 131 retrospectively collected HNSCC associated cervical lymph node metastases by real‐time polymerase chain reaction (PCR) p 16 immunohistochemistry its clinicopathological characteristics. Results. HPV16‐DNA overexpression were...
Sudden sensorineural hearing loss (SSHL) is a disease, which severely affects the patient's social and relational life. The underlying pathomechanisms have not been finally clarified yet outcome predictable.We conducted retrospective study in order to identify parameters that influence recovery. data base contains results of basic otoneurological tests clinical 198 patients with idiopathic SSHL at least 60 dB four frequencies, diagnosed treated University Hospital Münster, Germany, between...
Abstract Aberrant promoter methylation of specific genes and infection with human papillomavirus 16 (HPV16) are known risk factors for the development Head Neck Squamous Cell Carcinoma (HNSCC). Little knowledge exists on interaction HPV16 in HNSCC. The status 12 ( TIMP3 , CDH1 CDKN2A DAPK1 transcription factor 21 TCF21 ), CD44 MLH1 MGMT RASSF1 cyclin A1 CCNA1 LARS2 CEBPA ) was evaluated by methylation‐specific polymerase chain reaction 55 primary HNSCC 31 controls. results were correlated...
Summary The human nasal passage, from the anterior nares through vestibule to cavities, is an important habitat for opportunistic pathogens and commensals alike. This work sampled four different anatomical regions within passage across a large cohort of individuals ( n = 79) comprising suffering chronic inflammation clinically known as rhinosinusitis (CRS) not (CRS‐free). While had their own unique bacterial fingerprint that was consistent regions, these fingerprints formed into distinct...
To compare the outcome of hearing rehabilitation in younger versus older adult cochlear implant recipients. Analysis surgical and postoperative complications, as well number auditory therapy sessions two age groups.Individual retrospective cohort study.A 145 postlingually deafened adults was evaluated this study. The patients were divided into groups based on at implantation: Group I, 18 to 69 years; II, 70 older. Postoperative performance measured German Freiburg monosyllabic word test (FM)...
Sarcoidosis, a chronic, inflammatory disease that affects various different organs, is characterized by noncaseating epitheloid granulomas. This systemic process associated with an increased risk of cancer. Several cases sarcoidosis mimic metastatic tumor progression in radiological findings have been reported so far. However, there are also presented coexistence and metastasis, which caused diagnostic therapeutic dilemma. Due to inadequate current therapies, reliable differentiation between...
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial inflammatory disease of the mucous membranes nose and sinuses. Eosinophilic inflammation described as common endotype. The anti-IL-5 antibody mepolizumab was approved in November 2021 an add-on therapy to intranasal glucocorticosteroids for treatment adults severe chronic when systemic or surgery do not provide adequate control. While national international recommendations exist use CRSwNP, it has yet been adequately...
Hintergrund: Bei den verschiedenen Formen der Nasennebenhöhlenentzündungen werden akute, chronisch purulente und polypöse Sinusitiden unterschieden. In vorliegenden Studie untersuchten wir das Zytokin-profil verschiedener Sinusitisformen Nasennebenhöhlenschleimhaut, um zu überprüfen, ob ein spezifisches Zytokinmuster mit einer bestimmten Form Sinusitis assoziiert kann. Methode Patienten: Nasennebenhöhlenschleimhäute von Patienten chronischer (n = 7) akuter 10) sowie Polyposis nasi 8)...
To compare the diagnostic findings of ultrasonography and radiography in nasal fractures.In this prospective study, 63 patients (23 female 40 male; mean age, 26.8 years) with clinical signs a bone fracture were investigated. All underwent (lateral view nose plus occipitomental view) (10-MHz ultrasound scanner) dorsum lateral walls examination by 2 consultants. Thirty-six reduction. Two radiographs 3 images each patient analyzed experienced readers at different times. After assessing images,...
Background Characteristic infiltrates of eosinophils are a hallmark nasal polyps (NPs). Several studies suggest that members the CC chemokine family may be involved in this process. RANTES (regulated on activation, normal t-cell-expressed and secreted) is member with chemotactic activity mainly T lymphocytes. Thus, an interesting target for recruitment lymphocytes into nose. The degree tissue eosinophilia has been reported to correlate severeness symptomatology disease extension lower...