A5031452348- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Brain Metastases and Treatment
- Bioinformatics and Genomic Networks
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Extracellular vesicles in disease
- Lung Cancer Diagnosis and Treatment
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Wnt/β-catenin signaling in development and cancer
- Glioma Diagnosis and Treatment
- Gene expression and cancer classification
- Cardiac Valve Diseases and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Computational Drug Discovery Methods
- Radiomics and Machine Learning in Medical Imaging
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lymphoma Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Cancer Cells and Metastasis
- Pancreatic and Hepatic Oncology Research
- Respiratory Support and Mechanisms
- Cancer Research and Treatments
Universitätsmedizin Göttingen
2015-2025
University Hospital Münster
2019-2025
University of Münster
2022-2025
University of Göttingen
2013-2023
Klinik für Schlafmedizin
2023
West German Heart and Vascular Center Essen
2021-2022
University of Washington
2003
University of Vienna
1970
University of Bonn
1966
PURPOSE Phase III studies of intravenous amivantamab demonstrated efficacy across epidermal growth factor receptor ( EGFR )–mutated advanced non–small cell lung cancer (NSCLC). A subcutaneous formulation could improve tolerability and reduce administration time while maintaining efficacy. PATIENTS AND METHODS Patients with -mutated NSCLC who progressed after osimertinib platinum-based chemotherapy were randomly assigned 1:1 to receive or amivantamab, both combined lazertinib. Coprimary...
The objective of this study was to systematically assess the informational value, intention, source, and bias videos related dentistry available on video‐sharing Internet platform YouTube. YouTube ( www.youtube.com ) searched for dentistry, using system‐generated sorts “by relevance” “most viewed” two categories (All Education). Each first thirty results rated by assessors filling out a questionnaire each (total: 120). data were subjected statistical analysis Cohen's kappa, Pearson's...
Transcatheter aortic valve implantation (TAVI) represents a less invasive treatment option for elderly patients. Therefore, we aimed to determine the impact of frailty measured by Katz Index activities daily living (ADL) on short- and long-term mortality after TAVI.Our study included 300 consecutive patients (mean age, 82±5 years) who had undergone TAVI at our institution (158 transapical, 142 transfemoral procedures). At baseline, 144 were impaired in least one ADL therefore defined as...
A role of WNT signaling for primary breast cancers the basal-like subtype and as a predictor brain metastasis has been described. However, responsible ligand not identified. To further clarify this question, we comparatively investigated 22 human cancer metastases well highly invasive cell line MDA-MB-231 weakly motile MCF-7 models luminal subtype. WNT5A B were found overexpressed in cells compared with MCF-7. This corresponded to reduction invasiveness by inhibitors, whereas invasion was...
Tumor cells secrete not only a variety of soluble factors, but also extracellular vesicles that are known to support the establishment favorable tumor niche by influencing surrounding stroma cells.Here we show tumor-derived microvesicles (T-MV) directly influence enhancing their invasion in both autologous and heterologous manner.Neither respective vesicle-free supernatant nor MV from benign mammary mediate invasion.Uptake T-MV is essential for proinvasive effect.We further identify highly...
Abstract Aims Myocardial fibrosis (MF) might represent a key player in pathophysiology of heart failure aortic stenosis (AS). We aimed to assess its impact on left ventricular (LV) remodelling, recovery, and mortality after transcatheter valve implantation (TAVI) different AS subtypes. Methods results One hundred patients with severe were prospectively characterized clinically echocardiographically at baseline (BL), 6 months, 1 year, 2 years following TAVI. Left biopsies harvested...
Abstract Background Contemporary deep learning approaches show cutting-edge performance in a variety of complex prediction tasks. Nonetheless, the application healthcare remains limited since methods are often considered as non-interpretable black-box models. However, machine community made recent elaborations on interpretability explaining data point-specific decisions techniques. We believe that such explanations can assist need personalized precision medicine via patient-specific...
Colorectal cancer liver metastases (CRCLM) are associated with a poor prognosis, reflected by five-year survival rate of 14%. Anti-angiogenic therapy through anti-VEGF antibody administration is one the limited therapies available. However, only subgroup uses sprouting angiogenesis to secure their nutrients and oxygen supply, while others rely on vessel co-option (VCO). The distinct mode vascularization specific histopathological growth patterns (HGPs), which have proven prognostic...
Programmed death-ligand 1 expression currently represents the only validated predictive biomarker for immune checkpoint inhibition in metastatic NSCLC clinical routine, but it has limited value distinguishing responses. Assessment of KRAS and TP53 mutations (mut) as surrogate an immunosupportive tumor microenvironment (TME) might help to close this gap.
// Laila Siam 1 , Annalen Bleckmann 2, 3 Han-Ning Chaung 2 Alexander Mohr 4 Florian Klemm Alonso Barrantes-Freer 5 Raquel Blazquez Hendrik A. Wolff 6 Lüke 7 Veit Rohde Christine Stadelmann Tobias Pukrop Department of Neurosurgery, University Medical Center, Göttingen, Germany Hematology and Oncology, Statistics, Neuroradiology, Institute Neuropathology, Radiotherapy Radiation Internal Medicine III, Hospital Regensburg, Correspondence to: Pukrop, e-mail: tobias.pukrop@ukr.de Keywords:...
To evaluate whether tumour-derived microvesicles (T-MV), originating from the plasma membrane, represent suitable cancer biomarkers, we isolated MV peripheral blood samples of patients with locally advanced and/or metastatic solid tumours (n = 330, including 79 head & neck cancers, 74 lung 41 breast 28 colorectal cancers and 108 other forms) controls 103). Whole preparations were characterised using flow cytometry. While carrying tumour-associated proteins MUC1, EGFR EpCAM found to be...
Enrichment analysis is a popular approach to identify pathways or sets of genes which are significantly enriched in the context differentially expressed genes. The traditional gene set enrichment considers pathway as simple list disregarding any knowledge protein interactions. In contrast, new group so called topology-based methods integrates topological structure into analysis. We comparatively investigated and approaches, considering three four methods. These were compared two extensive...
The metastatic colonization of the brain by carcinoma cells is still barely understood, in particular when considering interactions with host tissue. comes a substantial destruction surrounding This leads to activation damage responses resident innate immune protect, repair, and organize wound healing, but may distract from tumoricidal actions. We recently demonstrated that microglia, CNS, assist cell invasion. Here we report this fatal side effect physiological response In slice coculture...
Abstract Mutations and activation of the PI3K signaling pathway in breast cancer cells have been linked to brain metastases. However, here we describe that some metastases samples protein expression components is restricted metastatic microenvironment. In contrast therapeutic effects inhibition on cells, reaction microenvironment less understood. Therefore aimed quantify activity metastasis investigate central nervous system (CNS) First, systematically metastases, performed a prospective...
Abstract Immunotherapy has revolutionized the treatment of patients with non‐small cell lung cancer (NSCLC). High expression tissue PD‐L1 (tPD‐L1) is currently only approved biomarker for predicting response. However, even tPD‐L1 low (1‐49%) and absent (<1%) might benefit from immunotherapy but, to date, there no reliable biomarker, that can predict response in this particular patient subgroup. This study aimed test whether tumour‐associated extracellular vesicles (EVs) could fill gap....
MitraClip implantation is evolving as a potential alternative treatment to conventional surgery in high-risk patients with significant mitral regurgitation (MR). However, outcome predictors are under-investigated. The aim of this study was identify midterm mortality and heart failure rehospitalisation after percutaneous valve repair MitraClip.A total 150 consecutive were followed for median 463 days. Survival analyses performed baseline characteristics, risk scores acute procedural success...
The release of extracellular vesicles (EVs) including small endosomal-derived exosomes (Exos, diameter < 100 nm) and large plasma membrane-derived microvesicles (MVs, > is a fundamental cellular process that occurs in all living cells. These transport proteins, lipids nucleic acids specific for their cell origin vitro studies have highlighted importance as mediators intercellular communication. EVs been successfully isolated from various body fluids especially blood identified promising...