A5067454034- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Congenital Heart Disease Studies
- Coronary Interventions and Diagnostics
- Cardiac Structural Anomalies and Repair
- Cardiovascular Disease and Adiposity
- Pulmonary Hypertension Research and Treatments
- Cardiomyopathy and Myosin Studies
- Ultrasound and Hyperthermia Applications
- Acute Myocardial Infarction Research
- Cardiac Arrhythmias and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Medical Imaging Techniques and Applications
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Effects of Exercise
- Cardiovascular Health and Disease Prevention
- Advanced X-ray and CT Imaging
- Viral Infections and Immunology Research
- Atomic and Subatomic Physics Research
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cardiac electrophysiology and arrhythmias
- Pericarditis and Cardiac Tamponade
- Cardiac pacing and defibrillation studies
University of Göttingen
2016-2025
German Centre for Cardiovascular Research
2016-2025
Universitätsmedizin Göttingen
2016-2025
King's College London
2012-2024
Beth Israel Deaconess Medical Center
2024
Universitätsklinikum Würzburg
2024
University Medical Center
2020-2024
HHL Leipzig Graduate School of Management
2024
Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR)
2023
Nephrologisches Zentrum Goettingen
2022-2023
Extracorporeal life support (ECLS) is increasingly used in the treatment of infarct-related cardiogenic shock despite a lack evidence regarding its effect on mortality. Download PDF Research Summary. In this multicenter trial, patients with acute myocardial infarction complicated by for whom early revascularization was planned were randomly assigned to receive ECLS plus usual medical (ECLS group) or alone (control group). The primary outcome death from any cause at 30 days. Safety outcomes...
Cardiovascular Magnetic Resonance myocardial feature tracking (CMR-FT) is a quantitative technique tissue voxel motion on standard steady-state free precession (SSFP) cine images to assess ventricular deformation. The importance of left atrial (LA) deformation assessment increasingly recognized and can be assessed with echocardiographic speckle tracking. However quantification has never previously been demonstrated CMR. We sought determine the feasibility reproducibility CMR-FT for...
Cardiovascular magnetic resonance myocardial feature tracking (CMR-FT) is a recently described method of post processing routine cine acquisitions which aims to provide quantitative measurements circumferentially and radially directed ventricular wall strain. Inter-study reproducibility important for serial assessments however has not been defined CMR-FT. 16 healthy volunteers were imaged 3 times within single day. The first examination was performed at 0900 after fasting immediately...
Although left atrial (LA) dysfunction is common in heart failure with preserved ejection fraction (HFpEF), its functional implications beyond the reflection of ventricular (LV) pathology are not well understood. The aim this study was to further characterize LA function HFpEF patients.We performed cardiac magnetic resonance myocardial feature tracking 22 patients and 12 without HFpEF. reservoir strain, conduit booster pump strain were quantified. Peak oxygen uptake (VO2max) determined....
<h3>Importance</h3> Internet and computer game addiction represent a growing mental health concern, acknowledged by the World Health Organization. <h3>Objective</h3> To determine whether manualized cognitive behavioral therapy (CBT), using short-term treatment for internet (STICA), is efficient in individuals experiencing addiction. <h3>Design, Setting, Participants</h3> A multicenter randomized clinical trial was conducted 4 outpatient clinics Germany Austria from January 24, 2012, to June...
Current tools to analyze memory dumps of systems running Microsoft Windows usually build on the concept enumerating lists maintained by kernel keep track processes, threads and other objects. Therefore they will frequently fail detect objects that are already terminated or which have been hidden Direct Kernel Object Manipulation techniques. This article analyzes in-memory structures represent processes threads. It develops search patterns then be used scan whole dump for traces said objects,...
Dobutamine stress cardiovascular magnetic resonance (DS-CMR) is an established tool to assess hibernating myocardium and ischemia. Analysis typically based on visual assessment with considerable operator dependency. CMR myocardial feature tracking (CMR-FT) a recently introduced technique for tissue voxel motion standard steady-state free precession (SSFP) images derive circumferential radial mechanics. We sought determine the feasibility reproducibility of CMR-FT quantitative wall during...
Abstract Aims Myocardial fibrosis (MF) might represent a key player in pathophysiology of heart failure aortic stenosis (AS). We aimed to assess its impact on left ventricular (LV) remodelling, recovery, and mortality after transcatheter valve implantation (TAVI) different AS subtypes. Methods results One hundred patients with severe were prospectively characterized clinically echocardiographically at baseline (BL), 6 months, 1 year, 2 years following TAVI. Left biopsies harvested...
Right heart catheterization using exercise stress is the reference standard for diagnosis of failure with preserved ejection fraction (HFpEF) but carries risk invasive procedure. We hypothesized that real-time cardiac magnetic resonance (RT-CMR) imaging pathophysiologic data at excellent temporal and spatial resolution may represent a contemporary noninvasive alternative diagnosing HFpEF.The HFpEF-Stress trial (CMR Exercise Stress Testing in HFpEF; URL: https://www.clinicaltrials.gov; Unique...
A multitude of cardiac magnetic resonance (CMR) techniques are used for myocardial strain assessment; however, studies comparing them limited. We sought to compare global longitudinal (GLS), circumferential (GCS), segmental (SLS), and (SCS) values, as well reproducibility between CMR feature tracking (FT), tagging (TAG), fast-strain-encoded (fast-SENC) techniques. Eighteen subjects (11 healthy volunteers seven patients with heart failure) underwent two scans (1.5T, Philips) identical...
This study aimed to identify the impact of increased epicardial adipose tissue (EAT) and its regional distribution on cardiac function in patients with diastolic dysfunction.
Extracorporeal life support (ECLS) has been increasingly used in the treatment of severe infarct-related cardiogenic shock last decade. The randomised ECLS-SHOCK trial demonstrated no benefit early routine use on 30-day all-cause death. We herein present mid-term results. At 1-year follow-up, there were significant differences or cardiovascular mortality, neurologic outcome, recurrent myocardial infarction, repeat revascularisation and rehospitalisations for heart failure between ECLS usual...
Abstract Background Accurate risk stratification is important to improve patient selection and outcome of patients with severe aortic stenosis (AS) undergoing transcatheter valve replacement (TAVR). As epicardial adipose tissue (EAT) discussed be involved in cardiovascular disease, it could useful as a marker poor prognosis AS TAVR. Methods A total 416 diagnosed by transthoracic echocardiography were assigned for TAVR enrolled systematic assessment. Patients underwent clinical surveys 5-year...
The dual-bolus protocol enables accurate quantification of myocardial blood flow (MBF) by first-pass perfusion cardiovascular magnetic resonance (CMR). However, despite the advantages and increasing demand for method MBF, thus far, it has not been widely used in field quantitative CMR. main reasons this are that setup is complex requires a state-of-the-art injector there also lack post processing software. As solution to one these problems, we have devised universal injection scheme use...
In patients with stable coronary artery disease (CAD), decisions regarding revascularisation are primarily driven by the severity and extent of luminal stenoses as determined invasive angiography. More recently, based on fractional flow reserve (FFR) have shown improved event free survival. Cardiovascular magnetic resonance (CMR) perfusion imaging has been to be non-inferior nuclear in a multi-centre setting superior single centre trial. addition, it is similar invasively FFR therefore...