A5084925061- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Infective Endocarditis Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Pulmonary Hypertension Research and Treatments
- Cardiac pacing and defibrillation studies
- Heart Failure Treatment and Management
- Viral Infections and Immunology Research
- Heart Rate Variability and Autonomic Control
- Cardiovascular Effects of Exercise
- Renal function and acid-base balance
- IL-33, ST2, and ILC Pathways
- Advanced MRI Techniques and Applications
- Immune Response and Inflammation
- Complement system in diseases
- Pericarditis and Cardiac Tamponade
- Ion Transport and Channel Regulation
- Cardiovascular Disease and Adiposity
- Elasticity and Material Modeling
- Migraine and Headache Studies
- Immune Cell Function and Interaction
- Congenital Heart Disease Studies
Leipzig Heart Institute
2016-2025
Leipzig University
2016-2024
École Polytechnique Fédérale de Lausanne
2023
University of Applied Sciences Landshut
2020-2022
University Hospital of Geneva
2021
University Medical Center Hamburg-Eppendorf
2019
University of Cologne
2019
University Hospital Leipzig
2017-2019
Universität Hamburg
2019
University Hospital Cologne
2019
Although left atrial (LA) dysfunction is common in heart failure with preserved ejection fraction (HFpEF), its functional implications beyond the reflection of ventricular (LV) pathology are not well understood. The aim this study was to further characterize LA function HFpEF patients.We performed cardiac magnetic resonance myocardial feature tracking 22 patients and 12 without HFpEF. reservoir strain, conduit booster pump strain were quantified. Peak oxygen uptake (VO2max) determined....
Both radiofrequency and ultrasound endovascular renal sympathetic denervation (RDN) have proven clinical efficacy for the treatment of hypertension. We performed a head-to-head comparison these technologies.Patients with resistant hypertension were randomly assigned in 1:1:1 manner to receive either (1) RDN main arteries; (2) arteries, side branches, accessories; or (3) an ultrasound-based artery. The primary end point was change systolic daytime ambulatory blood pressure at 3 months.Between...
Background: Recent trial data suggest that stratification of patients with heart failure preserved ejection fraction (HFpEF) according to left ventricular (LVEF) provides a means for dissecting different treatment responses. However, the differential pathophysiologic considerations have rarely been described. Methods: This prospective, single-center study analyzed consecutive symptomatic HFpEF diagnosed 2016 European Society Cardiology guidelines. Patients were grouped into LVEF 50% 60% and...
Abstract Aims The aim of this study was to assess the pathophysiological implications severe tricuspid regurgitation (TR) in patients with heart failure preserved ejection fraction (HFpEF) by using transcatheter edge‐to‐edge repair (T‐TEER) as a model right ventricular (RV) volume overload relief. Methods and results This prospective interventional single arm trial (NCT04782908) included invasively diagnosed HFpEF. following parameters were prospectively assessed before after T‐TEER: left...
Purpose To assess the diagnostic potential of texture analysis applied to T1 and T2 maps obtained with cardiac MRI for diagnosis acute infarctlike myocarditis. Materials Methods This prospective study from August 2012 May 2015 included 39 participants (overall mean age ± standard deviation, 34.7 years 12.2 [range, 18-63 years]; women, 46.1 10.8 24-63 men, 29.8 9.2 18-56 years]) Magnetic Resonance Imaging in Myocarditis (MyoRacer) trial clinical suspicion myocarditis presentation....
Background— Galectin (Gal)-3 is a β-galactoside-binding lectin and currently intensely studied as biomarker in heart failure. Gal-3 also exerts proinflammatory effects, at least extracardiac tissues. Objective of this study was to characterize the relationship plasma myocardial levels with cardiac fibrosis inflammation patients nonischemic dilated cardiomyopathy inflammatory (iCMP). Methods Results— Endomyocardial biopsies blood samples were obtained from newly diagnosed clinical suspicion...
Acquired thrombotic thrombocytopenic purpura (aTTP) is a rare but life-threatening condition. In 2018, the nanobody caplacizumab was approved for treatment of adults experiencing an acute episode aTTP, in conjunction with plasma exchange (PEX) and immunosuppression minimum 30 days after stopping daily PEX. We performed retrospective, observational analysis on use 60 patients from 29 medical centers Germany during disease management. Caplacizumab led to rapid normalization platelet count...
Background The establishment of a timely and correct diagnosis in heart failure–like myocarditis remains one the most challenging clinical cardiology. Purpose To assess diagnostic potential texture analysis with comparison to endomyocardial biopsy (EMB) as reference standard. Materials Methods Seventy-one study participants from Magnetic Resonance Imaging Myocarditis (MyoRacer) trial (ClinicalTrials.gov registration no. NCT02177630) suspicion for symptoms failure were prospectively included...
Tricuspid regurgitation (TR) has a poor prognosis and limited treatment options is frequently accompanied by right ventricular (RV) dysfunction. Transcatheter tricuspid valve interventions (TTVI) to reduce TR have been shown be safe feasible with encouraging early results. Patient selection for TTVI remains challenging, the role of function being unknown.The aims this study were 1) investigate survival in TTVI-treated patient population conservatively treated population, 2) evaluate outcome...
Background: Arterial hypertension is the most common comorbidity in patients with heart failure preserved ejection fraction (HFpEF) and mediates adverse hemodynamics through related aortic stiffness increased pulsatile load. We aimed to investigate clinical hemodynamic implications of renal sympathetic denervation (RDN) HFpEF uncontrolled arterial hypertension. Methods: Patients undergoing RDN between 2011 2018 a single-center were retrospectively analyzed classified as (n=99) or no HF...
Atrial functional tricuspid regurgitation (atrial TR) has received growing recognition as a TR entity with distinct cause owing to its independence from valvular tethering the predominant mechanism underlying TR. However, characterization of atrial varies, and universal definition is lacking.In total, 651 patients significant were analyzed, including 438 conservatively treated individuals 213 who transcatheter valve repair (TTVR). Based on clustering approach, we defined (TV) tenting height...
Background: Although systolic right ventricular (RV) dysfunction has been shown to be a potent predictor for adverse outcomes in patients with heart failure preserved ejection fraction (HFpEF), RV functional abnormalities the course of syndrome are not well characterized. We, therefore, sought assess load-independent and load-dependent diastolic characteristics function stable outpatients HFpEF. Methods Results: We invasively obtained left pressure–volume loops 24 HFpEF 9 without symptoms...
Abstract Introduction of the nanobody caplacizumab was shown to be effective in treatment acquired thrombotic thrombocytopenic purpura (aTTP) acute setting. The official recommendations include plasma exchange (PEX), immunosuppression, and use for a minimum 30 days after stopping daily PEX. This study retrospective, observational analysis 60 patients from 29 medical centers Germany. Immunosuppressive led rapid normalization ADAMTS13 activities (calculated median, 21 days). In 35 patients,...
In Pseudomonas aeruginosa , virulence determinants and biofilm formation are coordinated via a hierarchical quorum sensing cascade, which involves the transcriptional regulators LasR RhlR their cognate homoserine lactone activators C12-HSL [ N -(3-oxododecanoyl)- l -homoserine lactone] c4-hsl ( n -butanoyl- lactone), produced by LasI RhlI, respectively. The exoenzyme S regulon of P. comprises genes for type III secretion system four anti-host effector proteins (ExoS, T, U Y), translocated...
Abstract Background Heart failure with preserved ejection fraction (HFpEF) has recently been proposed as important comorbid condition in patients undergoing transcatheter aortic valve replacement (TAVR) for stenosis (AS). The H2FPEF-score and the HFA-PEFF-score are used to diagnose HFpEF, but their use might be hampered by lack of specificity TAVR-populations. Left atrial reservoir strain (LARS) emerged a powerful predictor outcomes AS irrespective (EF). Purpose To assess prognostic value...
Abstract Aims To characterize the prevalence and clinical relevance of malnutrition in patients undergoing transcatheter tricuspid valve edge‐to‐edge repair (TTVR). Methods results Overall, 86 consecutive (mean age 78 ± 7 years) with moderate‐to‐severe regurgitation (TR) at prohibitive surgical risk were analysed. Mini Nutritional Assessment (MNA), quality life assessment, 6‐min walk test distance laboratory analyses performed before 1 month after TTVR. A total 43 (50%) underwent concomitant...
To investigate whether there is evidence for distinct cardiac output (CO) based phenotypes in patients with chronic right heart failure associated severe tricuspid regurgitation (TR) and to characterize their impact on TR treatment outcome.A total of 132 underwent isolated transcatheter valve repair (TTVR) functional at two centres. Patients were clustered according k-means clustering into low [cardiac index (CI) < 1.7 L/min/m2 ], intermediate (CI 1.7-2.6 ) high CO > 2.6 clusters. All-cause...
Patients with isolated systolic hypertension (ISH) are thought to show a diminished blood pressure (BP)–lowering effect after renal sympathetic denervation (RDN). This conclusion is mostly derived from unipolar radiofrequency catheter ablation studies. Limited data for newer RDN technologies exist. We used the RADIOSOUND-HTN (Three-Arm Randomized Trial of Different Renal Denervation Devices and Techniques in With Resistant Hypertension) comparing 3 different approaches investigate possible...