Karl Fengler
A5091646719- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Cardiovascular Function and Risk Factors
- Heart Rate Variability and Autonomic Control
- Cardiac Structural Anomalies and Repair
- Venous Thromboembolism Diagnosis and Management
- Mechanical Circulatory Support Devices
- Cardiac Imaging and Diagnostics
- Cardiac Arrest and Resuscitation
- Hemodynamic Monitoring and Therapy
- Cardiac Valve Diseases and Treatments
- Pulmonary Hypertension Research and Treatments
- Renal and Vascular Pathologies
- Heart Failure Treatment and Management
- Migraine and Headache Studies
- Acute Myocardial Infarction Research
- Renal function and acid-base balance
- Acute Ischemic Stroke Management
- Sodium Intake and Health
- Cardiac pacing and defibrillation studies
- Advanced MRI Techniques and Applications
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Effects of Exercise
- Hormonal Regulation and Hypertension
- Traumatic Brain Injury and Neurovascular Disturbances
Leipzig Heart Institute
2016-2025
Leipzig University
2014-2025
Deutsches Herzzentrum der Charité
2014-2024
École Polytechnique Fédérale de Lausanne
2023
Radiance Technologies (United States)
2022-2023
University Hospital Leipzig
2017-2019
TU Dresden
2018
German Centre for Cardiovascular Research
2017
University Hospital Schleswig-Holstein
2017
University of Lübeck
2017
Although left atrial (LA) dysfunction is common in heart failure with preserved ejection fraction (HFpEF), its functional implications beyond the reflection of ventricular (LV) pathology are not well understood. The aim this study was to further characterize LA function HFpEF patients.We performed cardiac magnetic resonance myocardial feature tracking 22 patients and 12 without HFpEF. reservoir strain, conduit booster pump strain were quantified. Peak oxygen uptake (VO2max) determined....
Both radiofrequency and ultrasound endovascular renal sympathetic denervation (RDN) have proven clinical efficacy for the treatment of hypertension. We performed a head-to-head comparison these technologies.Patients with resistant hypertension were randomly assigned in 1:1:1 manner to receive either (1) RDN main arteries; (2) arteries, side branches, accessories; or (3) an ultrasound-based artery. The primary end point was change systolic daytime ambulatory blood pressure at 3 months.Between...
Background: Recent trial data suggest that stratification of patients with heart failure preserved ejection fraction (HFpEF) according to left ventricular (LVEF) provides a means for dissecting different treatment responses. However, the differential pathophysiologic considerations have rarely been described. Methods: This prospective, single-center study analyzed consecutive symptomatic HFpEF diagnosed 2016 European Society Cardiology guidelines. Patients were grouped into LVEF 50% 60% and...
Renal denervation (RDN) reduces blood pressure (BP) in patients with uncontrolled hypertension the absence of antihypertensive medications.
BACKGROUND: The SPYRAL HTN-ON MED (Global Clinical Study of Renal Denervation With the Symplicity Spyral Multi-electrode System in Patients Uncontrolled Hypertension Absence Antihypertensive Medications)trial showed significant office and nighttime systolic blood pressure (BP) reductions patients with hypertension following renal denervation (RDN) compared sham-control patients, despite similar 24-hour BP reductions. We antihypertensive medication changes among prespecified subpopulations....
Abstract Aims The aim of this study was to assess the pathophysiological implications severe tricuspid regurgitation (TR) in patients with heart failure preserved ejection fraction (HFpEF) by using transcatheter edge‐to‐edge repair (T‐TEER) as a model right ventricular (RV) volume overload relief. Methods and results This prospective interventional single arm trial (NCT04782908) included invasively diagnosed HFpEF. following parameters were prospectively assessed before after T‐TEER: left...
Background: The multicenter, international, randomized, blinded, sham-controlled RADIANCE-HTN SOLO trial (A Study of the ReCor Medical Paradise System in Clinical Hypertension) demonstrated a 6.3 mm Hg greater reduction daytime ambulatory systolic blood pressure (BP) at 2 months by endovascular ultrasound renal denervation (RDN) compared with sham procedure among patients not treated antihypertensive medications. We report 6-month results after addition recommended standardized stepped-care...
Background— Galectin (Gal)-3 is a β-galactoside-binding lectin and currently intensely studied as biomarker in heart failure. Gal-3 also exerts proinflammatory effects, at least extracardiac tissues. Objective of this study was to characterize the relationship plasma myocardial levels with cardiac fibrosis inflammation patients nonischemic dilated cardiomyopathy inflammatory (iCMP). Methods Results— Endomyocardial biopsies blood samples were obtained from newly diagnosed clinical suspicion...
Background: Arterial hypertension is the most common comorbidity in patients with heart failure preserved ejection fraction (HFpEF) and mediates adverse hemodynamics through related aortic stiffness increased pulsatile load. We aimed to investigate clinical hemodynamic implications of renal sympathetic denervation (RDN) HFpEF uncontrolled arterial hypertension. Methods: Patients undergoing RDN between 2011 2018 a single-center were retrospectively analyzed classified as (n=99) or no HF...
Shock is a life-threatening condition characterized by substantial alterations in the microcirculation. This study tests hypothesis that considering sublingual microcirculatory perfusion variables therapeutic management reduces 30-day mortality patients admitted to intensive care unit (ICU) with shock. randomized, prospective clinical multicenter trial-recruited an arterial lactate value above two mmol/L, requiring vasopressors despite adequate fluid resuscitation, regardless of cause All...
Background Single‐electrode ablation of the main renal artery for sympathetic denervation showed mixed blood pressure ( BP )‐lowering effects. Further improvement technique seems crucial to optimize effectiveness procedure. Because nerve fibers are closer lumen in distal part artery, treatment and its branches has been shown reduce variability effects preclinical studies a recent randomized trial. Whether this optimized improves clinical outcomes remains uncertain. We report 2‐center...
Experimental trials suggest improved outcome by mild therapeutic hypothermia for cardiogenic shock after acute myocardial infarction. The objective of this study was to investigate the hemodynamic effects in patients with complicating infarction.Patients (n=40) undergoing primary percutaneous coronary intervention without classic indications underwent randomization a 1:1 fashion 24 hours or control. end point cardiac power index at hours; secondary points included other parameters and serial...
Background: Although systolic right ventricular (RV) dysfunction has been shown to be a potent predictor for adverse outcomes in patients with heart failure preserved ejection fraction (HFpEF), RV functional abnormalities the course of syndrome are not well characterized. We, therefore, sought assess load-independent and load-dependent diastolic characteristics function stable outpatients HFpEF. Methods Results: We invasively obtained left pressure–volume loops 24 HFpEF 9 without symptoms...
Abstract Acute pulmonary embolism is a life-threatening condition caused by the thromboembolic obstruction of arteries, which often leads to hemodynamic instability, right ventricular failure, and potentially death. Patients with massive or high-risk PE are particularly vulnerable may not respond conventional treatments, necessitating implementation mechanical circulatory support. Here, we discuss recent advancements in diagnosis multidisciplinary management patients highlight need for rapid...
Renal sympathetic denervation seems to be less effective as a treatment for hypertension in patients with isolated systolic hypertension, condition associated elevated central arterial stiffness. Because can also caused by wave reflection or increased cardiac output, more differentiated approach might improve patient preselection renal denervation. We sought evaluate the additional predictive value of invasive pulse velocity response combined versus hypertension.Patients scheduled underwent...
A recurrent finding of trials on renal sympathetic denervation is a certain percentage non-responders. The aim this study was to examine the influence arterial stiffness predict response.Eighty-eight patients were included in study. Arterial measured by invasive pulse wave velocity. Antihypertensive medication had be unchanged during follow-up. Ambulatory blood pressure measurement (ABPM) used record before and six months after denervation. Fifty-eight without changes final analysis....
Background: After early revascularisation, restoration of macrocirculatory perfusion parameters is the primary objective in management cardiogenic shock complicated acute myocardial infarction. Nevertheless, vital organ may be compromised at systemic microcirculatory level, even patients with preserved macrohaemodynamics. Microvascular was shown to have independent prognostic value for mortality. The present study aims compare versus parameters. Methods: This substudy culprit lesion-only...
Patients with isolated systolic hypertension (ISH) are thought to show a diminished blood pressure (BP)–lowering effect after renal sympathetic denervation (RDN). This conclusion is mostly derived from unipolar radiofrequency catheter ablation studies. Limited data for newer RDN technologies exist. We used the RADIOSOUND-HTN (Three-Arm Randomized Trial of Different Renal Denervation Devices and Techniques in With Resistant Hypertension) comparing 3 different approaches investigate possible...