A5011403969- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Peripheral Artery Disease Management
- Cardiac Arrhythmias and Treatments
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Cardiac Valve Diseases and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Renal and Vascular Pathologies
- Vascular Procedures and Complications
- Heart Failure Treatment and Management
- Cardiac Health and Mental Health
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Diabetes Treatment and Management
- Aortic aneurysm repair treatments
- Transplantation: Methods and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Cardiac Arrest and Resuscitation
- Hemodynamic Monitoring and Therapy
- Cardiac Structural Anomalies and Repair
North Mississippi Medical Center
2011-2024
Radiance Technologies (United States)
2023
Certis USA (United States)
2022
Clinical Research Associates
2022
Yale University
2021
Brigham and Women's Hospital
1998-2018
Thrombolysis in Myocardial Infarction Study Group
2018
Christ Hospital
2017
Duke Medical Center
2016
Associates Research
2011
The ORBIT II (Evaluate the Safety and Efficacy of OAS in Treating Severely Calcified Coronary Lesions) trial evaluated safety efficacy coronary Orbital Atherectomy System (OAS) to prepare de novo, severely calcified lesions for stent placement. Despite advances interventional techniques, treatment remains a challenge. Stent placement these may result underexpansion, malapposition, procedural complications. is prospective, multicenter, nonblinded clinical that enrolled 443 consecutive...
The study sought to compare short-term outcomes in patients with femoropopliteal artery calcification receiving vessel preparation intravascular lithotripsy (IVL) or percutaneous transluminal angioplasty (PTA) prior drug-coated balloon (DCB) for symptomatic peripheral disease.Endovascular treatment of calcified lesions is associated suboptimal expansion and increased complication risk. Although initial results from single-arm studies IVL have been reported, comparative evidence randomized...
BACKGROUND: The SPYRAL HTN-ON MED (Global Clinical Study of Renal Denervation With the Symplicity Spyral Multi-electrode System in Patients Uncontrolled Hypertension Absence Antihypertensive Medications)trial showed significant office and nighttime systolic blood pressure (BP) reductions patients with hypertension following renal denervation (RDN) compared sham-control patients, despite similar 24-hour BP reductions. We antihypertensive medication changes among prespecified subpopulations....
Bioresorbable vascular scaffolds (BVS) were designed to improve late event-free survival compared with metallic drug-eluting stents. However, initial trials demonstrated worse early outcomes BVS, in part due suboptimal technique. In the large-scale, blinded ABSORB IV trial, polymeric everolimus-eluting BVS implanted improved technique noninferior 1-year cobalt chromium stents (CoCr-EES).
Harmonized Assessment by Randomized Multicentre Study of OrbusNEich's Combo StEnt (HARMONEE) (NCT02073565) was a randomized pivotal registration trial the stent, which combined sirolimus and an abluminal bioabsorbable polymer with novel endoluminal anti-CD34+ antibody coating designed to capture endothelial progenitor cells (EPC) promote percutaneous coronary intervention (PCI) site healing.Clinically stabilized PCI subjects were 1:1 receive or everolimus-eluting stents (EES). Between...
To evaluate the safety and effectiveness of Shockwave S4 intravascular lithotripsy (IVL) catheter in an "all-comers" cohort patients with calcified infrapopliteal lesions.The Disrupt PAD III Observational Study (NCT02923193) is a prospective, nonrandomized, multicenter single-arm study designed to assess "real-world" acute Peripheral IVL System for treatment de novo calcified, stenotic peripheral arteries. Patients were eligible enrollment if they had claudication or critical limb ischemia...
To determine the frequency and severity of clinically unrecognized left ventricular (LV) dysfunction related to cocaine use, 84 asymptomatic abusers underwent cardiac evaluation which included chest x-ray, electrocardiography (ECG), radionuclide angiography after a two-week abstinence from use. LV was discovered in 6/84 (7%). Regional wall motion abnormalities suggesting localized myocardial abnormality were found 2, whereas an ejection fraction less than 50% more global process noted 4. An...
Background: Surgical endarterectomy is currently considered the front-line therapy for treatment of calcified lesions in common femoral artery (CFA). Endovascular interventions have evolved, and their use increasing frequency. Intravascular lithotripsy (IVL) has shown promising safety effectiveness CFA a small pilot study, but “real-world” evidence from larger cohort lacking. Methods: The Disrupt PAD III Observational Study (NCT02923193) was prospective, multicenter registry designed to...
Abstract Objective To evaluate contrast media (CM) volume (CMV) saved using the DyeVert™ Plus Contrast Reduction System (DyeVert System, Osprey Medical) in patients undergoing diagnostic coronary angiogram (CAG) and/or percutaneous interventional (PCI) procedures performed with manual injections. Background Current guidelines advocate for monitoring and minimization of total CM chronic kidney disease (CKD) invasive cardiac procedures. The DyeVert is an FDA cleared device designed to reduce...
Diagnostic variables from insertable cardiac monitors may be useful in identifying patients at increased risk of heart failure (HF) events. High-risk alerts must coupled with interventions to improve outcomes. We aim assess the safety a predefined protocolized intervention pathway activated by monitor high-risk alerts.
To show that second- or third-degree atrioventricular block occurring as an early complication of acute inferior myocardial infarction is mediated by adenosine.Cardiac care unit.Uncontrolled, observational, hypothesis-driven study.Patients who developed clinically significant nodal blockade within 4 hours admission for infarction.Theophylline, 100 mg/min intravenously to a maximum 250 mg.Continuous multilead electrocardiographic monitoring before and after administration theophylline.During...