Bryan Wells
A5090270926- Renal and Vascular Pathologies
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Issues in Pregnancy
- Blood Pressure and Hypertension Studies
- Cardiac Structural Anomalies and Repair
- Peripheral Artery Disease Management
- Vascular anomalies and interventions
- Cardiac Health and Mental Health
- Coronary Artery Anomalies
- Abdominal vascular conditions and treatments
- Breast Cancer Treatment Studies
- Venous Thromboembolism Diagnosis and Management
- COVID-19 Clinical Research Studies
- Hemodynamic Monitoring and Therapy
- Coronary Interventions and Diagnostics
- Mechanical Circulatory Support Devices
- Cardiac Valve Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic aneurysm repair treatments
- Cardiovascular Function and Risk Factors
- Global Cancer Incidence and Screening
- Sodium Intake and Health
- Breast Lesions and Carcinomas
- Colorectal and Anal Carcinomas
- Heart Rate Variability and Autonomic Control
Emory University
2015-2025
Emory and Henry College
2018-2024
American Society of Echocardiography
2024
Littelfuse (United States)
2024
Beth Israel Deaconess Hospital
2024
Hope Heart Institute
2024
Providence College
2024
Radiance Technologies (United States)
2022-2023
Dartmouth–Hitchcock Medical Center
2023
Emory University Hospital
2023
Renal denervation (RDN) reduces blood pressure (BP) in patients with uncontrolled hypertension the absence of antihypertensive medications.
Ultrasound renal denervation (uRDN) was shown to lower blood pressure (BP) in patients with uncontrolled hypertension (HTN). Establishing the magnitude and consistency of uRDN effect across HTN spectrum is clinically important.
Background: The multicenter, international, randomized, blinded, sham-controlled RADIANCE-HTN SOLO trial (A Study of the ReCor Medical Paradise System in Clinical Hypertension) demonstrated a 6.3 mm Hg greater reduction daytime ambulatory systolic blood pressure (BP) at 2 months by endovascular ultrasound renal denervation (RDN) compared with sham procedure among patients not treated antihypertensive medications. We report 6-month results after addition recommended standardized stepped-care...
Importance Although early trials of endovascular renal denervation (RDN) for patients with resistant hypertension (RHTN) reported inconsistent results, ultrasound RDN (uRDN) was found to decrease blood pressure (BP) vs sham at 2 months in RHTN taking stable background medications the Study ReCor Medical Paradise System Clinical Hypertension (RADIANCE-HTN TRIO) trial. Objectives To report prespecified analysis persistence BP effects and safety uRDN 6 conjunction escalating antihypertensive...
This study utilized a transgenic mouse model that expresses an inducible dominant-negative mutation of the transforming growth factor (TGF)-beta type II receptor (DnTGFbetaRII) to define structural and functional responses left ventricle (LV) pressure-overload stress in absence intact TGF-beta signaling cascade. DnTGFbetaRII nontransgenic (NTG) control mice (male, 8-10 wk) were randomized receive Zn(2+) (25 mM ZnSO(4) drinking H(2)O induce gene expression) or tap then further undergo...
Background Myocardial infarction secondary to spontaneous coronary artery dissection (SCAD) can be traumatic and potentially trigger posttraumatic stress disorder (PTSD). In a large, multicenter, registry‐based cohort, we documented prevalence of lifetime past‐month SCAD‐induced PTSD, as well related treatment seeking, examined range health‐relevant correlates PTSD. Methods Results Patients with SCAD were enrolled in the iSCAD (International SCAD) Registry. At baseline, site investigators...
Introduction: Spontaneous coronary artery dissection (SCAD) is a nonatherosclerotic cause of myocardial infarction. Migraine headache has been reported to be common among patients with SCAD, but the degree migraine-related disability not quantified. Methods: Clinical data and variables were obtained from baseline assessment prospective, multicenter iSCAD Registry. Migraine-related was quantified using self-reported Disability Assessment (MIDAS). Demographic, clinical, psychosocial, medical...
Diabetes is associated with increased risk for complications following coronary bypass grafting (CABG) surgery. Augmented superoxide \((^{{\cdot}}\mathrm{O}_{2}^{{\bar{{\cdot}}}})\) production plays an important role in diabetic by causing vascular dysfunction. The potent vasoconstrictor endothelin-1 (ET-1) also elevated diabetes and CABG; however, the effect of ET-1 on \(^{{\cdot}}\mathrm{O}_{2}^{{\bar{{\cdot}}}}\) generation and/or dysfunction conduits remain unknown. Accordingly, this...
There is no gold standard for the measurement of pulmonary regurgitation (PR) severity. Two‐dimensional (2D) transthoracic echocardiography most commonly used to quantify PR severity using color Doppler criteria aortic regurgitation. However, this method limited by visualization only one or two dimensions proximal jet vena contracta (VC) precluding accurate assessment its shape size. This limitation would be expected obviated three‐dimensional (3D) echocardiography, which could provide a...
Craniocervical fibromuscular dysplasia (FMD) is associated with dissections and S-shaped curves in the internal carotid artery (ICA). We evaluated occurrence of S-curves patients presenting acute strokes due to ICA steno-occlusive dissections.This was a retrospective review interventional databases two academic tertiary-care institutions. The presence curves, C-shaped 360-degree loops, as well classic FMD atherosclerotic changes at bulb curve/loop determined. Cases were compared control...
Fibromuscular dysplasia (FMD) is a nonatherosclerotic arterial disease that predominately affects women and most commonly diagnosed in middle age. The natural history of FMD among patients at an older age not well understood.To examine the differences clinical presentation, bed involvement, vascular events, need for procedures between younger with FMD.Analysis baseline data enrolled US Registry as December 15, 2016, referral centers participating FMD. Patients 18 years time enrollment those...