A5039283573- Breast Cancer Treatment Studies
- Global Cancer Incidence and Screening
- Cutaneous Melanoma Detection and Management
- Palliative Care and End-of-Life Issues
- Breast Lesions and Carcinomas
- Colorectal Cancer Screening and Detection
- Patient-Provider Communication in Healthcare
- Radiomics and Machine Learning in Medical Imaging
- Clinical practice guidelines implementation
- BRCA gene mutations in cancer
- Cancer survivorship and care
- Economic and Financial Impacts of Cancer
- Colorectal Cancer Surgical Treatments
- MRI in cancer diagnosis
- Health Systems, Economic Evaluations, Quality of Life
- Pancreatic and Hepatic Oncology Research
- AI in cancer detection
- Nonmelanoma Skin Cancer Studies
- Advances in Oncology and Radiotherapy
- Breast Implant and Reconstruction
- Innovations in Medical Education
- Diversity and Career in Medicine
- Lung Cancer Diagnosis and Treatment
- Ultrasound and Hyperthermia Applications
- Immunotherapy and Immune Responses
Sunnybrook Health Science Centre
2016-2025
Health Sciences Centre
2016-2025
University of Toronto
2016-2025
Cancer Care Ontario
2010-2024
Texas A&M University
2024
Sunnybrook Research Institute
2011-2024
Corewell Health
2024
Michigan State University
2024
Grand Rapids Community College
2024
University Health Network
2010-2023
Sentinel-lymph-node biopsy is associated with increased melanoma-specific survival (i.e., until death from melanoma) among patients node-positive intermediate-thickness melanomas (1.2 to 3.5 mm). The value of completion lymph-node dissection for sentinel-node metastases not clear.
Purpose An increasing proportion of patients (> 30%) with node-positive breast cancer will obtain an axillary pathologic complete response after neoadjuvant chemotherapy (NAC). If sentinel node (SN) biopsy (SNB) is accurate in this setting, completion dissection (CND) morbidity could be avoided. Patients and Methods In the prospective multicentric SN FNAC study, biopsy-proven (T0-3, N1-2) underwent both SNB CND. Immunohistochemistry (IHC) use was mandatory, metastases any size, including...
The sensitivity of magnetic resonance imaging (MRI) for breast cancer screening exceeds that mammography. If MRI reduces mortality in women with a BRCA1 or BRCA2 mutation, it is expected the incidence advanced-stage cancers should be reduced undergoing compared those conventional screening.We followed 1,275 mutation mean 3.2 years. In total, 445 were enrolled an trial Toronto, Ontario, Canada, and 830 comparison group. cumulative incidences ductal carcinoma situ (DCIS), early-stage,...
<h3>BACKGROUND:</h3> To mitigate the effects of coronavirus disease 2019 (COVID-19), jurisdictions worldwide ramped down nonemergent surgeries, creating a global surgical backlog. We sought to estimate size backlog during COVID-19 in Ontario, Canada, and time resources required clear <h3>METHODS:</h3> used 6 Ontario or Canadian population administrative sources obtain data covering part all period between Jan. 1, 2017, June 13, 2020, on historical volumes operating room throughput...
Sex- and gender-based differences in a surgeon's medical practice communication may be factors patients' perioperative outcomes. Patients treated by female surgeons have improved 30-day However, whether these outcomes persist over longer follow-up has not been assessed.
The addition of breast magnetic resonance imaging (MRI) to screening mammography for women with BRCA mutations significantly increases sensitivity, but there is little data on clinical outcomes. We report performance, cancer stage, distant recurrence rate, and cancer-specific mortality in our study. From 1997 2009, 496 aged 25 65 years a known BRCA1/2 mutation, whom 380 had no previous history, were enrolled prospective trial that included annual MRI mammography. In 1847 rounds, 57 cancers...
Objectives We explored how to improve communication about low-risk lesions including labels, language and other strategies. Design Qualitative description thematic analysis examine the transcripts of telephone interviews with patients who had physicians; mapping Communication Accommodation Theory interpret themes. Setting Canada Participants 15 patients: 6 (40%) bladder, 5 (33%) prostate 4 (27%) cervix lesions; 13 physicians: 7 (54%) cervix, 3 (23%) bladder lesions. Main outcome measures...
The aim of this study was to investigate the potential diffuse optical spectroscopy for monitoring patients with locally advanced breast cancer (LABC) undergoing neoadjuvant chemotherapy. Fifteen women receiving treatment LABC had affected scanned before; 1 week, 4 weeks, and 8 weeks after initiation; before surgery. Optical properties related tissue microstructure biochemical composition were obtained. Clinical pathologic tumor response evaluated using whole-mount pathology mastectomy....
Purpose: Tumor grading is an important part of breast cancer diagnosis and currently requires biopsy as its standard. Here, the authors investigate quantitative ultrasound parameters in locally advanced cancers that can potentially separate tumors from normal tissue differentiate tumor grades. Methods: Ultrasound images radiofrequency data 42 patients were acquired analyzed. Parameters related to linear regression power spectrum—midband fit, slope, 0-MHz-intercept—were determined tissues....
Ultrasound elastography is a new imaging technique that can be used to assess tissue stiffness. The aim of this study was investigate the potential ultrasound for monitoring treatment response locally advanced breast cancer patients undergoing neoadjuvant therapy.Fifteen women receiving chemotherapy had affected scanned before, 1, 4, and 8 weeks following therapy initiation, then before surgery. Changes in elastographic parameters related biomechanical properties were determined compared...
Abstract Background This study was conducted in order to develop a model for predicting response neoadjuvant chemotherapy (NAC) patients with locally advanced breast cancer (LABC) using pretreatment quantitative ultrasound (QUS) radiomics. Methods multicenter involving four sites across North America, and appropriate approval obtained from the individual ethics committees. Eighty‐two LABC were included final analysis. Primary tumors scanned clinical system before NAC started. The contoured,...
Background Neoadjuvant chemotherapy (NAC) is the standard of care for patients with locally advanced breast cancer (LABC). The study was conducted to investigate utility quantitative ultrasound (QUS) carried out during NAC predict final tumour response in a multi-institutional setting. Methods Fifty-nine LABC were enrolled from three institutions North America (Sunnybrook Health Sciences Centre (Toronto, Canada), MD Anderson Cancer (Texas, USA), and Princess Margaret Canada)). QUS data...
<h3>Importance</h3> Sentinel lymph node (SLN) biopsy is a standard staging procedure for cutaneous melanoma. Regional disease control clinically important therapeutic goal of surgical intervention, including nodal surgery. <h3>Objective</h3> To determine how frequently SLN without completion dissection (CLND) results in long-term regional patients with metastases. <h3>Design, Setting, and Participants</h3> The second Multicenter Selective Lymphadenectomy Trial (MSLT-II), prospective...