A5042850690- Breast Cancer Treatment Studies
- Cutaneous Melanoma Detection and Management
- Protein Degradation and Inhibitors
- Melanoma and MAPK Pathways
- Immunotherapy and Immune Responses
- Breast Lesions and Carcinomas
- Cancer Cells and Metastasis
- Gastric Cancer Management and Outcomes
- TGF-β signaling in diseases
- Epigenetics and DNA Methylation
- Microtubule and mitosis dynamics
- Nonmelanoma Skin Cancer Studies
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Cancer, Lipids, and Metabolism
- HIV/AIDS Research and Interventions
- Colorectal Cancer Treatments and Studies
- CAR-T cell therapy research
- Biotin and Related Studies
- Cancer-related gene regulation
- Epilepsy research and treatment
- Colorectal Cancer Surgical Treatments
- Cancer Genomics and Diagnostics
- HIV Research and Treatment
- Colorectal Cancer Screening and Detection
University of California, Los Angeles
2016-2025
Cedars-Sinai Medical Center
2013-2025
UCLA Health
2022-2024
Cancer Research And Biostatistics
2009-2023
UCLA Medical Center
2016-2022
Ronald Reagan UCLA Medical Center
2017-2020
Health Services Research & Development
2020
Healthcare Technology Innovation Centre
2020
Saint John's Health Center
2008-2017
Mattel Children's Hospital
2006-2017
To elucidate molecular pathways contributing to metastatic cancer progression and poor clinical outcome in serous ovarian cancer.Poor survival signatures from three different datasets were compared a common set of genes was identified. The predictive value this gene signature validated independent datasets. expression the evaluated primary, metastatic, and/or recurrent cancers using quantitative PCR situ hybridization. Alterations by TGF-β1 functional consequences loss COL11A1 pharmacologic...
<h3>Objective</h3> To assess survival and identify predictors of in patients with systemic sclerosis-interstitial lung disease (SSc-ILD) who participated the Scleroderma Lung Studies (SLS) I II. <h3>Methods</h3> SLS randomised 158 SSc-ILD to 1 year oral cyclophosphamide (CYC) vs placebo. II 142 CYC followed by placebo 2 years mycophenolate mofetil. Counting process Cox proportional hazard modelling identified variables associated long-term mortality Internal validation was performed using...
ABSTRACT Background The incidence of persistent clinical symptoms and risk factors in Post-Acute Sequelae SARS-CoV-2 (PASC) diverse US cohorts is unclear. While there are a disproportionate share COVID-19 deaths older patients, ethnic minorities, socially disadvantaged populations the USA, little information available on association these PASC. Objective To evaluate demographic characteristics with development Design Prospective observational cohort hospitalized high-risk outpatients, April...
Gene expression signatures for a basal-like breast cancer (BLBC) subtype have been associated with poor clinical outcomes, but molecular basis this disease remains unclear. Here, we report overexpression of the transcription factor FOXC1 as consistent feature BLBC compared other subtypes cancer. Elevated predicted overall survival in (P = 0.0001), independently clinicopathologic prognostic factors including lymph node status, along higher incidence brain metastasis 0.02) and shorter...
Abstract Purpose: The CpG island methylator phenotype (CIMP) may be associated with development of malignancy through coordinated inactivation tumor suppressor and tumor-related genes (TRG) methylation multiple noncoding, methylated-in-tumor (MINT) loci. These epigenetic changes create a distinct CIMP pattern that has been linked to recurrence survival in gastrointestinal cancers. Because TRGs also shown malignant melanoma, we hypothesized the existence clinically significant cutaneous...
Hypermethylation of the promoter region tumor-related genes (TRGs) has been shown to silence gene expression during melanoma progression, whereas microRNA-29(miR-29) found downregulate DNA methyltransferases DNMT3A and DNMT3B which were as essential methylation TRGs. We hypothesized that level miR-29 is associated TRG status may have prognostic utility in melanoma. AJCC stage I-IV cutaneous paraffin-embedded archival tissue (PEAT) specimens (n=149) assessed. Expression isoforms a, b, c...
Lymph node metastases are the most significant prognostic indicator for patients with breast cancer. Sentinel biopsy (SNB) has led to an increase in detection of micrometastases sentinel (SN). This prospective study was designed determine survival impact SNs invasive is based on new sixth edition American Joint Committee Cancer (AJCC) staging criteria.Between January 1, 1992 and April 30, 1999, 790 entered this at John Wayne Institute. The SN examined first by hematoxylin eosin (HE), if...
Abstract Older patients with melanoma have lower rates of sentinel lymph node (LN) metastases yet paradoxically inferior survival. Patient age correlated an inability to retain Technetium radiotracer during LN biopsy in more than 1,000 patients, and high counts better We hypothesized that loss integrity the lymphatic vasculature due extracellular matrix (ECM) degradation might play a role. implicated HAPLN1 age-dependent ECM dermis. Here, we queried whether could be altered ECM. Lymphatic...
The sensitivity of current surveillance methods for detecting early-stage hepatocellular carcinoma (HCC) is suboptimal. Extracellular vesicles (EVs) are promising circulating biomarkers early cancer detection. In this study, we aim to develop an HCC EV-based surface protein assay detection HCC.Tissue microarray was used evaluate four potential HCC-associated markers. An EV assay, composed covalent chemistry-mediated purification and real-time immuno-polymerase chain reaction readouts,...
Breast cancer is the most common neoplasm in North American women. The psychosocial impact of breast has been extensively studied, and a number investigators have attempted to characterize women who are at high risk for increased morbidity. Although detailed interview performed by professional clinical standard assessment, such interviews usually time-consuming expensive, thus rarely performed. This study was designed develop strategy rapid identification newly-diagnosed patients A sample...
Estrogen receptor (ER)-positive breast cancers are considered prognostically more favorable than ER-negative tumors, whereas human epidermal growth factor (HER)2/neu-positive associated with worse prognosis. The objective of the present study was to determine whether ER-positive and status relates epigenetic changes in cancer-related genes. To evaluate differences tumor-related genes relating ER HER2/neu primary we examined promoter methylation region CpG islands eight major (RASSF1A, CCND2,...
RUNX3 is a known tumor suppressor gene in several carcinomas. Aberration expression has not been described for cutaneous melanoma. Therefore, we assessed the of melanoma and its regulatory mechanisms relative to progression.The mRNA miR-532-5p (microRNA) was lines primary metastatic tumors.RUNX3 down-regulated 11 (100%) normal melanocytes (P < 0.001). Among 123 tumors 12 skin samples, significantly melanomas (n = 82; P 0.02) metastasis 41; 0.0001) versus 12). This suggested that...
Hypopituitarism is common after moderate and severe traumatic brain injury (TBI). Herein, we address the association between mild TBI (mTBI) pituitary metabolic function in retired football players. Retirees 30-65 years of age, with one or more National Football League (NFL) play poor quality life (QoL) based on Short Form 36 (SF-36) Mental Component Score (MCS) were prospectively enrolled. Pituitary hormonal syndrome (MetS) testing was performed. Using a glucagon stimulation test, growth...
<h3>Importance</h3> Nonanatomic factors, such as histologic grade and biomarkers, can guide breast cancer management but are not included in the current TNM staging system. <h3>Objective</h3> To use an example triple-negative phenotype (TNP) defined by absence of estrogen receptor (ER), progesterone (PR), human epidermal growth factor 2 (HER2) to examine whether inclusion improves prognostic accuracy for cancer. <h3>Design, Setting, Participants</h3> Women diagnosed with primary invasive...
<h3>Importance</h3> Sentinel lymph node (SLN) biopsy is a standard staging procedure for cutaneous melanoma. Regional disease control clinically important therapeutic goal of surgical intervention, including nodal surgery. <h3>Objective</h3> To determine how frequently SLN without completion dissection (CLND) results in long-term regional patients with metastases. <h3>Design, Setting, and Participants</h3> The second Multicenter Selective Lymphadenectomy Trial (MSLT-II), prospective...